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Showing 13 to 24 of 219 entries
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Corrigendum: mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.

Genes & development

Kon N, Ou Y, Wang SJ, Li H, Rustgi AK, Gu W.
PMID: 33526587
Genes Dev. 2021 Feb 01;35(3):300. doi: 10.1101/gad.348236.121.

No abstract available.

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Kon N, Ou Y, Wang SJ, et al. Corrigendum: mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression. Genes Dev. 2021;35(3):300doi: 10.1101/gad.348236.121.
Kon, N., Ou, Y., Wang, S. J., Li, H., Rustgi, A. K., & Gu, W. (2021). Corrigendum: mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression. Genes & development, 35(3), 300. https://doi.org/10.1101/gad.348236.121
Kon, Ning, et al. "Corrigendum: mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression." Genes & development vol. 35,3 (2021): 300. doi: https://doi.org/10.1101/gad.348236.121
Kon N, Ou Y, Wang SJ, Li H, Rustgi AK, Gu W. Corrigendum: mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression. Genes Dev. 2021 Feb 01;35(3):300. doi: 10.1101/gad.348236.121. PMID: 33526587; PMCID: PMC7849359.
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Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies.

Genes & development

Rabhi N, Farmer SR.
PMID: 34725126
Genes Dev. 2021 Nov 01;35(21):1395-1397. doi: 10.1101/gad.349053.121.

Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is...

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Rabhi N, Farmer SR. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes Dev. 2021;35(21):1395-1397doi: 10.1101/gad.349053.121.
Rabhi, N., & Farmer, S. R. (2021). Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes & development, 35(21), 1395-1397. https://doi.org/10.1101/gad.349053.121
Rabhi, Nabil, and Farmer, Stephen R. "Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies." Genes & development vol. 35,21 (2021): 1395-1397. doi: https://doi.org/10.1101/gad.349053.121
Rabhi N, Farmer SR. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes Dev. 2021 Nov 01;35(21):1395-1397. doi: 10.1101/gad.349053.121. PMID: 34725126; PMCID: PMC8559673.
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Opening the window for endothelial-to-hematopoietic transition.

Genes & development

Samarakkody AS, Cantor AB.
PMID: 34725127
Genes Dev. 2021 Nov 01;35(21):1398-1400. doi: 10.1101/gad.349056.121.

Definitive long-term hematopoietic stem cells (LT-HSCs) arise during embryogenesis in a process termed endothelial-to-hematopoietic transition (EHT), in which specialized hemogenic endothelial cells (HECs) transform into hematopoietic cells. The transcription factor RUNX1 marks HECs and is essential for EHT. Ectopic

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Samarakkody AS, Cantor AB. Opening the window for endothelial-to-hematopoietic transition. Genes Dev. 2021;35(21):1398-1400doi: 10.1101/gad.349056.121.
Samarakkody, A. S., & Cantor, A. B. (2021). Opening the window for endothelial-to-hematopoietic transition. Genes & development, 35(21), 1398-1400. https://doi.org/10.1101/gad.349056.121
Samarakkody, Ann Sanoji, and Cantor, Alan B. "Opening the window for endothelial-to-hematopoietic transition." Genes & development vol. 35,21 (2021): 1398-1400. doi: https://doi.org/10.1101/gad.349056.121
Samarakkody AS, Cantor AB. Opening the window for endothelial-to-hematopoietic transition. Genes Dev. 2021 Nov 01;35(21):1398-1400. doi: 10.1101/gad.349056.121. PMID: 34725127; PMCID: PMC8559677.
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REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.

Genes & development

Rovira M, Atla G, Maestro MA, Grau V, García-Hurtado J, Maqueda M, Mosquera JL, Yamada Y, Kerr-Conte J, Pattou F, Ferrer J.
PMID: 34385258
Genes Dev. 2021 Sep 01;35(17):1229-1242. doi: 10.1101/gad.348501.121. Epub 2021 Aug 12.

Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrinogenesis in the embryonic pancreas. However,...

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Rovira M, Atla G, Maestro MA, et al. REST is a major negative regulator of endocrine differentiation during pancreas organogenesis. Genes Dev. 2021;35(17):1229-1242doi: 10.1101/gad.348501.121.
Rovira, M., Atla, G., Maestro, M. A., Grau, V., García-Hurtado, J., Maqueda, M., Mosquera, J. L., Yamada, Y., Kerr-Conte, J., Pattou, F., & Ferrer, J. (2021). REST is a major negative regulator of endocrine differentiation during pancreas organogenesis. Genes & development, 35(17), 1229-1242. https://doi.org/10.1101/gad.348501.121
Rovira, Meritxell, et al. "REST is a major negative regulator of endocrine differentiation during pancreas organogenesis." Genes & development vol. 35,17 (2021): 1229-1242. doi: https://doi.org/10.1101/gad.348501.121
Rovira M, Atla G, Maestro MA, Grau V, García-Hurtado J, Maqueda M, Mosquera JL, Yamada Y, Kerr-Conte J, Pattou F, Ferrer J. REST is a major negative regulator of endocrine differentiation during pancreas organogenesis. Genes Dev. 2021 Sep 01;35(17):1229-1242. doi: 10.1101/gad.348501.121. Epub 2021 Aug 12. PMID: 34385258; PMCID: PMC8415321.
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Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion.

Genes & development

Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK.
PMID: 34385262
Genes Dev. 2021 Sep 01;35(17):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12.

Multiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the majority have unknown functions. We observed specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α and β cells. Loss of cilia disrupts...

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Wu CT, Hilgendorf KI, Bevacqua RJ, et al. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes Dev. 2021;35(17):1243-1255doi: 10.1101/gad.348261.121.
Wu, C. T., Hilgendorf, K. I., Bevacqua, R. J., Hang, Y., Demeter, J., Kim, S. K., & Jackson, P. K. (2021). Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes & development, 35(17), 1243-1255. https://doi.org/10.1101/gad.348261.121
Wu, Chien-Ting, et al. "Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion." Genes & development vol. 35,17 (2021): 1243-1255. doi: https://doi.org/10.1101/gad.348261.121
Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes Dev. 2021 Sep 01;35(17):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12. PMID: 34385262; PMCID: PMC8415323.
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Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology.

Genes & development

Feng S, Manley JL.
PMID: 34819354
Genes Dev. 2021 Dec 01;35(23):1579-1594. doi: 10.1101/gad.348858.121. Epub 2021 Nov 24.

The nucleolus is an important cellular compartment in which ribosomal RNAs (rRNAs) are transcribed and where certain stress pathways that are crucial for cell growth are coordinated. Here we report novel functions of the DNA replication and repair factor...

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Feng S, Manley JL. Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology. Genes Dev. 2021;35(23):1579-1594doi: 10.1101/gad.348858.121.
Feng, S., & Manley, J. L. (2021). Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology. Genes & development, 35(23), 1579-1594. https://doi.org/10.1101/gad.348858.121
Feng, Shuang, and Manley, James L. "Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology." Genes & development vol. 35,23 (2021): 1579-1594. doi: https://doi.org/10.1101/gad.348858.121
Feng S, Manley JL. Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology. Genes Dev. 2021 Dec 01;35(23):1579-1594. doi: 10.1101/gad.348858.121. Epub 2021 Nov 24. PMID: 34819354.
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Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.

Genes & development

Humpton TJ, Nomura K, Weber J, Magnussen HM, Hock AK, Nixon C, Dhayade S, Stevenson D, Huang DT, Strathdee D, Blyth K, Vousden KH.
PMID: 34210805
Genes Dev. 2021 Jul 01;35(13):1071. doi: 10.1101/gad.348692.121.

No abstract available.

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Humpton TJ, Nomura K, Weber J, et al. Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021;35(13):1071doi: 10.1101/gad.348692.121.
Humpton, T. J., Nomura, K., Weber, J., Magnussen, H. M., Hock, A. K., Nixon, C., Dhayade, S., Stevenson, D., Huang, D. T., Strathdee, D., Blyth, K., & Vousden, K. H. (2021). Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes & development, 35(13), 1071. https://doi.org/10.1101/gad.348692.121
Humpton, Timothy J, et al. "Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice." Genes & development vol. 35,13 (2021): 1071. doi: https://doi.org/10.1101/gad.348692.121
Humpton TJ, Nomura K, Weber J, Magnussen HM, Hock AK, Nixon C, Dhayade S, Stevenson D, Huang DT, Strathdee D, Blyth K, Vousden KH. Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021 Jul 01;35(13):1071. doi: 10.1101/gad.348692.121. PMID: 34210805; PMCID: PMC8247601.
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Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.

Genes & development

Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ.
PMID: 34711655
Genes Dev. 2021 Nov 01;35(21):1527-1547. doi: 10.1101/gad.349048.121. Epub 2021 Oct 28.

Understanding the genetic control of human embryonic stem cell function is foundational for developmental biology and regenerative medicine. Here we describe an integrated genome-scale loss- and gain-of-function screening approach to identify genetic networks governing embryonic stem cell proliferation and...

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Naxerova K, Di Stefano B, Makofske JL, et al. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev. 2021;35(21):1527-1547doi: 10.1101/gad.349048.121.
Naxerova, K., Di Stefano, B., Makofske, J. L., Watson, E. V., de Kort, M. A., Martin, T. D., Dezfulian, M., Ricken, D., Wooten, E. C., Kuroda, M. I., Hochedlinger, K., & Elledge, S. J. (2021). Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes & development, 35(21), 1527-1547. https://doi.org/10.1101/gad.349048.121
Naxerova, Kamila, et al. "Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior." Genes & development vol. 35,21 (2021): 1527-1547. doi: https://doi.org/10.1101/gad.349048.121
Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJ. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev. 2021 Nov 01;35(21):1527-1547. doi: 10.1101/gad.349048.121. Epub 2021 Oct 28. PMID: 34711655; PMCID: PMC8559676.
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The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly.

Genes & development

Pyatnitskaya A, Andreani J, Guérois R, De Muyt A, Borde V.
PMID: 34969823
Genes Dev. 2021 Dec 30; doi: 10.1101/gad.348973.121. Epub 2021 Dec 30.

Meiotic recombination is triggered by programmed double-strand breaks (DSBs), a subset of these being repaired as crossovers, promoted by eight evolutionarily conserved proteins, named ZMM. Crossover formation is functionally linked to synaptonemal complex (SC) assembly between homologous chromosomes, but...

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Pyatnitskaya A, Andreani J, Guérois R, et al. The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Genes Dev. 2021;doi: 10.1101/gad.348973.121.
Pyatnitskaya, A., Andreani, J., Guérois, R., De Muyt, A., & Borde, V. (2021). The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Genes & development, . https://doi.org/10.1101/gad.348973.121
Pyatnitskaya, Alexandra, et al. "The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly." Genes & development vol. (2021). doi: https://doi.org/10.1101/gad.348973.121
Pyatnitskaya A, Andreani J, Guérois R, De Muyt A, Borde V. The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Genes Dev. 2021 Dec 30; doi: 10.1101/gad.348973.121. Epub 2021 Dec 30. PMID: 34969823.
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Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes.

Genes & development

Howell ED, Yzaguirre AD, Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K, Speck NA.
PMID: 34675061
Genes Dev. 2021 Nov 01;35(21):1475-1489. doi: 10.1101/gad.348738.121. Epub 2021 Oct 21.

Hematopoietic stem and progenitor cells (HSPCs) are generated de novo in the embryo from hemogenic endothelial cells (HECs) via an endothelial-to-hematopoietic transition (EHT) that requires the transcription factor RUNX1. Ectopic expression of RUNX1 alone can efficiently promote EHT and...

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Howell ED, Yzaguirre AD, Gao P, et al. Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes Dev. 2021;35(21):1475-1489doi: 10.1101/gad.348738.121.
Howell, E. D., Yzaguirre, A. D., Gao, P., Lis, R., He, B., Lakadamyali, M., Rafii, S., Tan, K., & Speck, N. A. (2021). Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes & development, 35(21), 1475-1489. https://doi.org/10.1101/gad.348738.121
Howell, Elizabeth D, et al. "Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes." Genes & development vol. 35,21 (2021): 1475-1489. doi: https://doi.org/10.1101/gad.348738.121
Howell ED, Yzaguirre AD, Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K, Speck NA. Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes Dev. 2021 Nov 01;35(21):1475-1489. doi: 10.1101/gad.348738.121. Epub 2021 Oct 21. PMID: 34675061; PMCID: PMC8559682.
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Disruption of origin chromatin structure by helicase activation in the absence of DNA replication.

Genes & development

Hoffman RA, MacAlpine HK, MacAlpine DM.
PMID: 34556529
Genes Dev. 2021 Oct 01;35(19):1339-1355. doi: 10.1101/gad.348517.121. Epub 2021 Sep 23.

Prior to initiation of DNA replication, the eukaryotic helicase, Mcm2-7, must be activated to unwind DNA at replication start sites in early S phase. To study helicase activation within origin chromatin, we constructed a conditional mutant of the polymerase...

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Hoffman RA, MacAlpine HK, MacAlpine DM. Disruption of origin chromatin structure by helicase activation in the absence of DNA replication. Genes Dev. 2021;35(19):1339-1355doi: 10.1101/gad.348517.121.
Hoffman, R. A., MacAlpine, H. K., & MacAlpine, D. M. (2021). Disruption of origin chromatin structure by helicase activation in the absence of DNA replication. Genes & development, 35(19), 1339-1355. https://doi.org/10.1101/gad.348517.121
Hoffman, Rachel A, et al. "Disruption of origin chromatin structure by helicase activation in the absence of DNA replication." Genes & development vol. 35,19 (2021): 1339-1355. doi: https://doi.org/10.1101/gad.348517.121
Hoffman RA, MacAlpine HK, MacAlpine DM. Disruption of origin chromatin structure by helicase activation in the absence of DNA replication. Genes Dev. 2021 Oct 01;35(19):1339-1355. doi: 10.1101/gad.348517.121. Epub 2021 Sep 23. PMID: 34556529; PMCID: PMC8494203.
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Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing.

Genes & development

Kumar A, Yu CWH, Rodríguez-Molina JB, Li XH, Freund SMV, Passmore LA.
PMID: 34593603
Genes Dev. 2021 Nov 01;35(21):1510-1526. doi: 10.1101/gad.348671.121. Epub 2021 Sep 30.

Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein complex essential for mRNA 3' end processing in eukaryotes. It contains an endonuclease that cleaves pre-mRNAs, and a polymerase that adds a poly(A) tail onto the cleaved 3' end. Several CPF...

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Kumar A, Yu CWH, Rodríguez-Molina JB, et al. Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing. Genes Dev. 2021;35(21):1510-1526doi: 10.1101/gad.348671.121.
Kumar, A., Yu, C. W. H., Rodríguez-Molina, J. B., Li, X. H., Freund, S. M. V., & Passmore, L. A. (2021). Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing. Genes & development, 35(21), 1510-1526. https://doi.org/10.1101/gad.348671.121
Kumar, Ananthanarayanan, et al. "Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing." Genes & development vol. 35,21 (2021): 1510-1526. doi: https://doi.org/10.1101/gad.348671.121
Kumar A, Yu CWH, Rodríguez-Molina JB, Li XH, Freund SMV, Passmore LA. Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing. Genes Dev. 2021 Nov 01;35(21):1510-1526. doi: 10.1101/gad.348671.121. Epub 2021 Sep 30. PMID: 34593603; PMCID: PMC8559680.
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Showing 13 to 24 of 219 entries