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Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies.

Genes & development

Rabhi N, Farmer SR.
PMID: 34725126
Genes Dev. 2021 Nov 01;35(21):1395-1397. doi: 10.1101/gad.349053.121.

Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is...

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Rabhi N, Farmer SR. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes Dev. 2021;35(21):1395-1397doi: 10.1101/gad.349053.121.
Rabhi, N., & Farmer, S. R. (2021). Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes & development, 35(21), 1395-1397. https://doi.org/10.1101/gad.349053.121
Rabhi, Nabil, and Farmer, Stephen R. "Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies." Genes & development vol. 35,21 (2021): 1395-1397. doi: https://doi.org/10.1101/gad.349053.121
Rabhi N, Farmer SR. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies. Genes Dev. 2021 Nov 01;35(21):1395-1397. doi: 10.1101/gad.349053.121. PMID: 34725126; PMCID: PMC8559673.
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Kinesin-1 captures RNA cargo in its adaptable coils.

Genes & development

Cross JA, Woolfson DN, Dodding MP.
PMID: 34210804
Genes Dev. 2021 Jul 01;35(13):937-939. doi: 10.1101/gad.348691.121.

The prototypic and ubiquitous microtubule motor, kinesin-1, uses a variety of adaptor proteins to facilitate the selective transport of diverse cargo within the cell. These cargo adaptors bind to the motor complex through interactions with the kinesin light or...

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Cross JA, Woolfson DN, Dodding MP. Kinesin-1 captures RNA cargo in its adaptable coils. Genes Dev. 2021;35(13):937-939doi: 10.1101/gad.348691.121.
Cross, J. A., Woolfson, D. N., & Dodding, M. P. (2021). Kinesin-1 captures RNA cargo in its adaptable coils. Genes & development, 35(13), 937-939. https://doi.org/10.1101/gad.348691.121
Cross, Jessica A, et al. "Kinesin-1 captures RNA cargo in its adaptable coils." Genes & development vol. 35,13 (2021): 937-939. doi: https://doi.org/10.1101/gad.348691.121
Cross JA, Woolfson DN, Dodding MP. Kinesin-1 captures RNA cargo in its adaptable coils. Genes Dev. 2021 Jul 01;35(13):937-939. doi: 10.1101/gad.348691.121. PMID: 34210804; PMCID: PMC8247605.
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Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis.

Genes & development

Trakala M, Aggarwal M, Sniffen C, Zasadil L, Carroll A, Ma D, Su XA, Wangsa D, Meyer A, Sieben CJ, Zhong J, Hsu PH, Paradis G, Ried T, Holland A, Van Deursen J, Amon A.
PMID: 34266888
Genes Dev. 2021 Aug 01;35(15):1079-1092. doi: 10.1101/gad.348341.121. Epub 2021 Jul 15.

Chromosome gains and losses are a frequent feature of human cancers. However, how these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An initial comparison of existing chromosomal instability (CIN) mouse models suggests that aneuploidy accumulates to...

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Trakala M, Aggarwal M, Sniffen C, et al. Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes Dev. 2021;35(15):1079-1092doi: 10.1101/gad.348341.121.
Trakala, M., Aggarwal, M., Sniffen, C., Zasadil, L., Carroll, A., Ma, D., Su, X. A., Wangsa, D., Meyer, A., Sieben, C. J., Zhong, J., Hsu, P. H., Paradis, G., Ried, T., Holland, A., Van Deursen, J., & Amon, A. (2021). Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes & development, 35(15), 1079-1092. https://doi.org/10.1101/gad.348341.121
Trakala, Marianna, et al. "Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis." Genes & development vol. 35,15 (2021): 1079-1092. doi: https://doi.org/10.1101/gad.348341.121
Trakala M, Aggarwal M, Sniffen C, Zasadil L, Carroll A, Ma D, Su XA, Wangsa D, Meyer A, Sieben CJ, Zhong J, Hsu PH, Paradis G, Ried T, Holland A, Van Deursen J, Amon A. Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes Dev. 2021 Aug 01;35(15):1079-1092. doi: 10.1101/gad.348341.121. Epub 2021 Jul 15. PMID: 34266888; PMCID: PMC8336892.
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Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy.

Genes & development

Yoon JH, Johnson RE, Prakash L, Prakash S.
PMID: 34385260
Genes Dev. 2021 Sep 01;35(17):1256-1270. doi: 10.1101/gad.348662.121. Epub 2021 Aug 12.

Chemotherapy with cisplatin becomes limiting due to toxicity and secondary malignancies. In principle, therapeutics could be improved by targeting translesion synthesis (TLS) polymerases (Pols) that promote replication through intrastrand cross-links, the major cisplatin-induced DNA adduct. However, to specifically target...

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Yoon JH, Johnson RE, Prakash L, et al. Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy. Genes Dev. 2021;35(17):1256-1270doi: 10.1101/gad.348662.121.
Yoon, J. H., Johnson, R. E., Prakash, L., & Prakash, S. (2021). Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy. Genes & development, 35(17), 1256-1270. https://doi.org/10.1101/gad.348662.121
Yoon, Jung-Hoon, et al. "Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy." Genes & development vol. 35,17 (2021): 1256-1270. doi: https://doi.org/10.1101/gad.348662.121
Yoon JH, Johnson RE, Prakash L, Prakash S. Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy. Genes Dev. 2021 Sep 01;35(17):1256-1270. doi: 10.1101/gad.348662.121. Epub 2021 Aug 12. PMID: 34385260; PMCID: PMC8415319.
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Role of 53BP1 in end protection and DNA synthesis at DNA breaks.

Genes & development

Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, Zheng L, Shen B, Sleckman BP, Chen BR, Nussenzweig A.
PMID: 34503990
Genes Dev. 2021 Oct 01;35(19):1356-1367. doi: 10.1101/gad.348667.121. Epub 2021 Sep 09.

Double-strand break (DSB) repair choice is greatly influenced by the initial processing of DNA ends. 53BP1 limits the formation of recombinogenic single-strand DNA (ssDNA) in BRCA1-deficient cells, leading to defects in homologous recombination (HR). However, the exact mechanisms by...

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Paiano J, Zolnerowich N, Wu W, et al. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes Dev. 2021;35(19):1356-1367doi: 10.1101/gad.348667.121.
Paiano, J., Zolnerowich, N., Wu, W., Pavani, R., Wang, C., Li, H., Zheng, L., Shen, B., Sleckman, B. P., Chen, B. R., & Nussenzweig, A. (2021). Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes & development, 35(19), 1356-1367. https://doi.org/10.1101/gad.348667.121
Paiano, Jacob, et al. "Role of 53BP1 in end protection and DNA synthesis at DNA breaks." Genes & development vol. 35,19 (2021): 1356-1367. doi: https://doi.org/10.1101/gad.348667.121
Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, Zheng L, Shen B, Sleckman BP, Chen BR, Nussenzweig A. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes Dev. 2021 Oct 01;35(19):1356-1367. doi: 10.1101/gad.348667.121. Epub 2021 Sep 09. PMID: 34503990; PMCID: PMC8494207.
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Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide.

Genes & development

Pérez-Calero C, Bayona-Feliu A, Xue X, Barroso SI, Muñoz S, González-Basallote VM, Sung P, Aguilera A.
PMID: 33861722
Genes Dev. 2021 Apr 01;35(7):573. doi: 10.1101/gad.348365.121.

No abstract available.

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Pérez-Calero C, Bayona-Feliu A, Xue X, et al. Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. Genes Dev. 2021;35(7):573doi: 10.1101/gad.348365.121.
Pérez-Calero, C., Bayona-Feliu, A., Xue, X., Barroso, S. I., Muñoz, S., González-Basallote, V. M., Sung, P., & Aguilera, A. (2021). Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. Genes & development, 35(7), 573. https://doi.org/10.1101/gad.348365.121
Pérez-Calero, Carmen, et al. "Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide." Genes & development vol. 35,7 (2021): 573. doi: https://doi.org/10.1101/gad.348365.121
Pérez-Calero C, Bayona-Feliu A, Xue X, Barroso SI, Muñoz S, González-Basallote VM, Sung P, Aguilera A. Corrigendum: UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. Genes Dev. 2021 Apr 01;35(7):573. doi: 10.1101/gad.348365.121. PMID: 33861722; PMCID: PMC8015723.
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The .

Genes & development

Simoneau A, Xiong R, Zou L.
PMID: 34385259
Genes Dev. 2021 Sep 01;35(17):1271-1289. doi: 10.1101/gad.348479.121. Epub 2021 Aug 12.

PARP inhibitor (PARPi) is widely used to treat BRCA1/2-deficient tumors, but why PARPi is more effective than other DNA-damaging drugs is unclear. Here, we show that PARPi generates DNA double-strand breaks (DSBs) predominantly in a

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Simoneau A, Xiong R, Zou L. The . Genes Dev. 2021;35(17):1271-1289doi: 10.1101/gad.348479.121.
Simoneau, A., Xiong, R., & Zou, L. (2021). The . Genes & development, 35(17), 1271-1289. https://doi.org/10.1101/gad.348479.121
Simoneau, Antoine, et al. "The ." Genes & development vol. 35,17 (2021): 1271-1289. doi: https://doi.org/10.1101/gad.348479.121
Simoneau A, Xiong R, Zou L. The . Genes Dev. 2021 Sep 01;35(17):1271-1289. doi: 10.1101/gad.348479.121. Epub 2021 Aug 12. PMID: 34385259; PMCID: PMC8415318.
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Corrigendum: Developmental regulation of cell type-specific transcription by novel promoter-proximal sequence elements.

Genes & development

Lu D, Sin HS, Lu C, Fuller MT.
PMID: 32482715
Genes Dev. 2020 Jun 01;34(11):861. doi: 10.1101/gad.339655.120.

No abstract available.

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Lu D, Sin HS, Lu C, et al. Corrigendum: Developmental regulation of cell type-specific transcription by novel promoter-proximal sequence elements. Genes Dev. 2020;34(11):861doi: 10.1101/gad.339655.120.
Lu, D., Sin, H. S., Lu, C., & Fuller, M. T. (2020). Corrigendum: Developmental regulation of cell type-specific transcription by novel promoter-proximal sequence elements. Genes & development, 34(11), 861. https://doi.org/10.1101/gad.339655.120
Lu, Dan, et al. "Corrigendum: Developmental regulation of cell type-specific transcription by novel promoter-proximal sequence elements." Genes & development vol. 34,11 (2020): 861. doi: https://doi.org/10.1101/gad.339655.120
Lu D, Sin HS, Lu C, Fuller MT. Corrigendum: Developmental regulation of cell type-specific transcription by novel promoter-proximal sequence elements. Genes Dev. 2020 Jun 01;34(11):861. doi: 10.1101/gad.339655.120. PMID: 32482715; PMCID: PMC7263149.
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Structural basis of PETISCO complex assembly during piRNA biogenesis in .

Genes & development

Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J, Ketting RF, Falk S.
PMID: 34413138
Genes Dev. 2021 Sep 01;35(17):1304-1323. doi: 10.1101/gad.348648.121. Epub 2021 Aug 19.

Piwi-interacting RNAs (piRNAs) constitute a class of small RNAs that bind PIWI proteins and are essential to repress transposable elements in the animal germline, thereby promoting genome stability and maintaining fertility.

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Perez-Borrajero C, Podvalnaya N, Holleis K, et al. Structural basis of PETISCO complex assembly during piRNA biogenesis in . Genes Dev. 2021;35(17):1304-1323doi: 10.1101/gad.348648.121.
Perez-Borrajero, C., Podvalnaya, N., Holleis, K., Lichtenberger, R., Karaulanov, E., Simon, B., Basquin, J., Hennig, J., Ketting, R. F., & Falk, S. (2021). Structural basis of PETISCO complex assembly during piRNA biogenesis in . Genes & development, 35(17), 1304-1323. https://doi.org/10.1101/gad.348648.121
Perez-Borrajero, Cecilia, et al. "Structural basis of PETISCO complex assembly during piRNA biogenesis in ." Genes & development vol. 35,17 (2021): 1304-1323. doi: https://doi.org/10.1101/gad.348648.121
Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J, Ketting RF, Falk S. Structural basis of PETISCO complex assembly during piRNA biogenesis in . Genes Dev. 2021 Sep 01;35(17):1304-1323. doi: 10.1101/gad.348648.121. Epub 2021 Aug 19. PMID: 34413138; PMCID: PMC8415317.
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Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors.

Genes & development

Zhang J, Gundu A, Strahl BD.
PMID: 34819351
Genes Dev. 2021 Dec 01;35(23):1678-1692. doi: 10.1101/gad.348904.121. Epub 2021 Nov 24.

How transcription programs rapidly adjust to changing metabolic and cellular cues remains poorly defined. Here, we reveal a function for the Yaf9 component of the SWR1-C and NuA4 chromatin regulatory complexes in maintaining timely transcription of metabolic genes across...

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Zhang J, Gundu A, Strahl BD. Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Genes Dev. 2021;35(23):1678-1692doi: 10.1101/gad.348904.121.
Zhang, J., Gundu, A., & Strahl, B. D. (2021). Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Genes & development, 35(23), 1678-1692. https://doi.org/10.1101/gad.348904.121
Zhang, Jibo, et al. "Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors." Genes & development vol. 35,23 (2021): 1678-1692. doi: https://doi.org/10.1101/gad.348904.121
Zhang J, Gundu A, Strahl BD. Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Genes Dev. 2021 Dec 01;35(23):1678-1692. doi: 10.1101/gad.348904.121. Epub 2021 Nov 24. PMID: 34819351.
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Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones.

Genes & development

Liu CP, Jin W, Hu J, Wang M, Chen J, Li G, Xu RM.
PMID: 34819355
Genes Dev. 2021 Dec 01;35(23):1610-1624. doi: 10.1101/gad.349100.121. Epub 2021 Nov 24.

Chromosomal duplication requires de novo assembly of nucleosomes from newly synthesized histones, and the process involves a dynamic network of interactions between histones and histone chaperones. sNASP and ASF1 are two major histone H3-H4 chaperones found in distinct and...

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Liu CP, Jin W, Hu J, et al. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev. 2021;35(23):1610-1624doi: 10.1101/gad.349100.121.
Liu, C. P., Jin, W., Hu, J., Wang, M., Chen, J., Li, G., & Xu, R. M. (2021). Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes & development, 35(23), 1610-1624. https://doi.org/10.1101/gad.349100.121
Liu, Chao-Pei, et al. "Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones." Genes & development vol. 35,23 (2021): 1610-1624. doi: https://doi.org/10.1101/gad.349100.121
Liu CP, Jin W, Hu J, Wang M, Chen J, Li G, Xu RM. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev. 2021 Dec 01;35(23):1610-1624. doi: 10.1101/gad.349100.121. Epub 2021 Nov 24. PMID: 34819355.
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Robotic-assisted surgical removal of retroperitoneal schwannoma by transmesocolic access.

International braz j urol : official journal of the Brazilian Society of Urology

Tobias-Machado M, Genes WEP, Pazeto CL, Faria EF, Zampolli HC.
PMID: 31851478
Int Braz J Urol. 2020 Jan-Feb;46(1):143-144. doi: 10.1590/S1677-5538.IBJU.2018.0624.

No abstract available.

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Tobias-Machado M, Genes WEP, Pazeto CL, et al. Robotic-assisted surgical removal of retroperitoneal schwannoma by transmesocolic access. Int Braz J Urol. 2020;46(1):143-144doi: 10.1590/S1677-5538.IBJU.2018.0624.
Tobias-Machado, M., Genes, W. E. P., Pazeto, C. L., Faria, E. F., & Zampolli, H. C. (2020). Robotic-assisted surgical removal of retroperitoneal schwannoma by transmesocolic access. International braz j urol : official journal of the Brazilian Society of Urology, 46(1), 143-144. https://doi.org/10.1590/S1677-5538.IBJU.2018.0624
Tobias-Machado, Marcos, et al. "Robotic-assisted surgical removal of retroperitoneal schwannoma by transmesocolic access." International braz j urol : official journal of the Brazilian Society of Urology vol. 46,1 (2020): 143-144. doi: https://doi.org/10.1590/S1677-5538.IBJU.2018.0624
Tobias-Machado M, Genes WEP, Pazeto CL, Faria EF, Zampolli HC. Robotic-assisted surgical removal of retroperitoneal schwannoma by transmesocolic access. Int Braz J Urol. 2020 Jan-Feb;46(1):143-144. doi: 10.1590/S1677-5538.IBJU.2018.0624. PMID: 31851478; PMCID: PMC6968896.
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Showing 25 to 36 of 219 entries