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Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on .

Analytical biochemistry

Yang T, Zhou J, Fang L, Wang M, Dilinuer M, Ainiwaer A.
PMID: 34419454
Anal Biochem. 2021 Oct 15;631:114342. doi: 10.1016/j.ab.2021.114342. Epub 2021 Aug 19.

18β-Glycyrrhetinic acid (GA) is the triterpenoid aglycone component of glycyrrhizic acid, a natural product of traditional Chinese medicine, and has been proven to possess a variety of pharmacological effects. The protection function and the mechanism of GA on rats...

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Yang T, Zhou J, Fang L, et al. Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on . Anal Biochem. 2021;631:114342doi: 10.1016/j.ab.2021.114342.
Yang, T., Zhou, J., Fang, L., Wang, M., Dilinuer, M., & Ainiwaer, A. (2021). Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on . Analytical biochemistry, 631114342. https://doi.org/10.1016/j.ab.2021.114342
Yang, Tao, et al. "Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on ." Analytical biochemistry vol. 631 (2021): 114342. doi: https://doi.org/10.1016/j.ab.2021.114342
Yang T, Zhou J, Fang L, Wang M, Dilinuer M, Ainiwaer A. Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on . Anal Biochem. 2021 Oct 15;631:114342. doi: 10.1016/j.ab.2021.114342. Epub 2021 Aug 19. PMID: 34419454.
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The effect of glycyrrhizin acid on .

Gastroenterology and hepatology from bed to bench

Orazizadeh M, Khorsandi L, Mansouri E, Fakhredini F.
PMID: 32308939
Gastroenterol Hepatol Bed Bench. 2020;13(2):168-176.

AIM: This research studied the effects of glycyrrhizic acid (GA) on apoptosis induced with by titanium dioxide (NTiO2) in the liver of rats.BACKGROUND: It is widely accepted that the contamination resulting from nanoparticles (NPs) is an emerging dangerous issue....

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Orazizadeh M, Khorsandi L, Mansouri E, et al. The effect of glycyrrhizin acid on . Gastroenterol Hepatol Bed Bench. 2020;13(2):168-176
Orazizadeh, M., Khorsandi, L., Mansouri, E., & Fakhredini, F. (2020). The effect of glycyrrhizin acid on . Gastroenterology and hepatology from bed to bench, 13(2), 168-176.
Orazizadeh, Mahmoud, et al. "The effect of glycyrrhizin acid on ." Gastroenterology and hepatology from bed to bench vol. 13,2 (2020): 168-176.
Orazizadeh M, Khorsandi L, Mansouri E, Fakhredini F. The effect of glycyrrhizin acid on . Gastroenterol Hepatol Bed Bench. 2020;13(2):168-176. PMID: 32308939; PMCID: PMC7149808.
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Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and oxidative stress.

Inflammopharmacology

Zeeshan M, Atiq A, Ain QU, Ali J, Khan S, Ali H.
PMID: 34420176
Inflammopharmacology. 2021 Oct;29(5):1539-1553. doi: 10.1007/s10787-021-00866-z. Epub 2021 Aug 22.

OBJECTIVES: 5-Fluorouracil (5-FU), a chemotherapeutic drug, has severe deteriorating effects on the intestine, leading to mucositis. Glycyrrhizic acid is a compound derived from a common herbal plant Glycyrrhiza glabra, with mucoprotective, antioxidant and anti-inflammatory actions, however, associated with poor...

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Zeeshan M, Atiq A, Ain QU, et al. Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and oxidative stress. Inflammopharmacology. 2021;29(5):1539-1553doi: 10.1007/s10787-021-00866-z.
Zeeshan, M., Atiq, A., Ain, Q. U., Ali, J., Khan, S., & Ali, H. (2021). Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and oxidative stress. Inflammopharmacology, 29(5), 1539-1553. https://doi.org/10.1007/s10787-021-00866-z
Zeeshan, Mahira, et al. "Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and oxidative stress." Inflammopharmacology vol. 29,5 (2021): 1539-1553. doi: https://doi.org/10.1007/s10787-021-00866-z
Zeeshan M, Atiq A, Ain QU, Ali J, Khan S, Ali H. Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and oxidative stress. Inflammopharmacology. 2021 Oct;29(5):1539-1553. doi: 10.1007/s10787-021-00866-z. Epub 2021 Aug 22. PMID: 34420176.
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How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption.

Cureus

Patel P, Aknouk M, Dawson A, Aya A, Kanukuntla A, Kata P, De Dona A.
PMID: 34422484
Cureus. 2021 Jul 18;13(7):e16454. doi: 10.7759/cureus.16454. eCollection 2021 Jul.

Licorice has been around for centuries and has been commercialized in the food, tobacco, and healthcare industry. Historically, its therapeutic benefits have been reaped in countless ways, including as a thirst sensation suppressor in battlefields, flavoring agent in medicinal...

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Patel P, Aknouk M, Dawson A, et al. How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. Cureus. 2021;13(7):e16454doi: 10.7759/cureus.16454.
Patel, P., Aknouk, M., Dawson, A., Aya, A., Kanukuntla, A., Kata, P., & De Dona, A. (2021). How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. Cureus, 13(7), e16454. https://doi.org/10.7759/cureus.16454
Patel, Palak, et al. "How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption." Cureus vol. 13,7 (2021): e16454. doi: https://doi.org/10.7759/cureus.16454
Patel P, Aknouk M, Dawson A, Aya A, Kanukuntla A, Kata P, De Dona A. How Much Is Too Much? Exploring Pseudohyperaldosteronism in Glycyrrhizic Acid Toxicity From Chronic Licorice Root Consumption. Cureus. 2021 Jul 18;13(7):e16454. doi: 10.7759/cureus.16454. eCollection 2021 Jul. PMID: 34422484; PMCID: PMC8369979.
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Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond.

Bioorganic chemistry

Zhang Q, Wang Y, Wang Z, Mohammed EAH, Zhao Q, He D, Wang Z.
PMID: 34902645
Bioorg Chem. 2021 Dec 06;119:105542. doi: 10.1016/j.bioorg.2021.105542. Epub 2021 Dec 06.

A series of glycyrrhetinic acid (GA, aglycone of glycyrrhizic acid) derivatives containing disulfide bond were synthesized and their anti-inflammatory and anti-fibrosis activities were evaluated in vivo and in vitro. Among them, compound 7 displayed the highest toxicity to all...

Cite
Zhang Q, Wang Y, Wang Z, et al. Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorg Chem. 2021;119:105542doi: 10.1016/j.bioorg.2021.105542.
Zhang, Q., Wang, Y., Wang, Z., Mohammed, E. A. H., Zhao, Q., He, D., & Wang, Z. (2021). Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorganic chemistry, 119105542. https://doi.org/10.1016/j.bioorg.2021.105542
Zhang, Qiuping, et al. "Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond." Bioorganic chemistry vol. 119 (2021): 105542. doi: https://doi.org/10.1016/j.bioorg.2021.105542
Zhang Q, Wang Y, Wang Z, Mohammed EAH, Zhao Q, He D, Wang Z. Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorg Chem. 2021 Dec 06;119:105542. doi: 10.1016/j.bioorg.2021.105542. Epub 2021 Dec 06. PMID: 34902645.
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Licorice-Yuanhua Herbal Pair Induces Ileum Injuries Through Weakening Epithelial and Mucous Barrier Functions: Saponins, Flavonoids, and Di-Terpenes All Involved.

Frontiers in pharmacology

Yu J, Zhang D, Liang Y, Zhang Z, Guo J, Chen Y, Yan Y, Liu H, Lei L, Wang Z, Tang Z, Tang Y, Duan JA.
PMID: 32765254
Front Pharmacol. 2020 Jul 16;11:869. doi: 10.3389/fphar.2020.00869. eCollection 2020.

In traditional Chinese Medicine (TCM), the licorice-yuanhua herbal pair is one of the most representative incompatible herbal pairs recorded in the "eighteen incompatible herbal pairs" theory. Previous studies of our research group have demonstrated several gut-related side-effects induced by...

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Yu J, Zhang D, Liang Y, et al. Licorice-Yuanhua Herbal Pair Induces Ileum Injuries Through Weakening Epithelial and Mucous Barrier Functions: Saponins, Flavonoids, and Di-Terpenes All Involved. Front Pharmacol. 2020;11:869doi: 10.3389/fphar.2020.00869.
Yu, J., Zhang, D., Liang, Y., Zhang, Z., Guo, J., Chen, Y., Yan, Y., Liu, H., Lei, L., Wang, Z., Tang, Z., Tang, Y., & Duan, J. A. (2020). Licorice-Yuanhua Herbal Pair Induces Ileum Injuries Through Weakening Epithelial and Mucous Barrier Functions: Saponins, Flavonoids, and Di-Terpenes All Involved. Frontiers in pharmacology, 11869. https://doi.org/10.3389/fphar.2020.00869
Yu, Jingao, et al. "Licorice-Yuanhua Herbal Pair Induces Ileum Injuries Through Weakening Epithelial and Mucous Barrier Functions: Saponins, Flavonoids, and Di-Terpenes All Involved." Frontiers in pharmacology vol. 11 (2020): 869. doi: https://doi.org/10.3389/fphar.2020.00869
Yu J, Zhang D, Liang Y, Zhang Z, Guo J, Chen Y, Yan Y, Liu H, Lei L, Wang Z, Tang Z, Tang Y, Duan JA. Licorice-Yuanhua Herbal Pair Induces Ileum Injuries Through Weakening Epithelial and Mucous Barrier Functions: Saponins, Flavonoids, and Di-Terpenes All Involved. Front Pharmacol. 2020 Jul 16;11:869. doi: 10.3389/fphar.2020.00869. eCollection 2020. PMID: 32765254; PMCID: PMC7378851.
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Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway.

Pharmacological research

Wang Y, Wang X, Li Y, Xue Z, Shao R, Li L, Zhu Y, Zhang H, Yang J.
PMID: 35033647
Pharmacol Res. 2022 Jan 13;106083. doi: 10.1016/j.phrs.2022.106083. Epub 2022 Jan 13.

The pathogenic hyper-inflammatory response has been revealed as the major cause of the severity and death of the Corona Virus Disease 2019 (COVID-19). Xuanfei Baidu Decoction (XFBD) as one of the "three medicines and three prescriptions" for the clinically...

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Wang Y, Wang X, Li Y, et al. Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacol Res. 2022;106083doi: 10.1016/j.phrs.2022.106083.
Wang, Y., Wang, X., Li, Y., Xue, Z., Shao, R., Li, L., Zhu, Y., Zhang, H., & Yang, J. (2022). Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacological research, 106083. https://doi.org/10.1016/j.phrs.2022.106083
Wang, Yuying, et al. "Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway." Pharmacological research vol. (2022): 106083. doi: https://doi.org/10.1016/j.phrs.2022.106083
Wang Y, Wang X, Li Y, Xue Z, Shao R, Li L, Zhu Y, Zhang H, Yang J. Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacol Res. 2022 Jan 13;106083. doi: 10.1016/j.phrs.2022.106083. Epub 2022 Jan 13. PMID: 35033647.
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Efficacy of a pharmaceutical preparation based on glycyrrhizic acid in a challenge study of white spot syndrome in white shrimp (.

Aquaculture (Amsterdam, Netherlands)

Ocampo L, Chavez B, Tapia G, Ibarra C, Sumano H.
PMID: 32287456
Aquaculture. 2014 May 20;428:280-283. doi: 10.1016/j.aquaculture.2014.03.005. Epub 2014 Mar 22.

There is a lack of preventive and therapeutic drug-based treatments for the shrimp viral disease known as white spot syndrome (WSSV). Thus a challenge study inducing WSSV in juvenile white shrimp (

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Ocampo L, Chavez B, Tapia G, et al. Efficacy of a pharmaceutical preparation based on glycyrrhizic acid in a challenge study of white spot syndrome in white shrimp (. Aquaculture. 2014;428:280-283doi: 10.1016/j.aquaculture.2014.03.005.
Ocampo, L., Chavez, B., Tapia, G., Ibarra, C., & Sumano, H. (2014). Efficacy of a pharmaceutical preparation based on glycyrrhizic acid in a challenge study of white spot syndrome in white shrimp (. Aquaculture (Amsterdam, Netherlands), 428280-283. https://doi.org/10.1016/j.aquaculture.2014.03.005
Ocampo, Luis, et al. "Efficacy of a pharmaceutical preparation based on glycyrrhizic acid in a challenge study of white spot syndrome in white shrimp (." Aquaculture (Amsterdam, Netherlands) vol. 428 (2014): 280-283. doi: https://doi.org/10.1016/j.aquaculture.2014.03.005
Ocampo L, Chavez B, Tapia G, Ibarra C, Sumano H. Efficacy of a pharmaceutical preparation based on glycyrrhizic acid in a challenge study of white spot syndrome in white shrimp (. Aquaculture. 2014 May 20;428:280-283. doi: 10.1016/j.aquaculture.2014.03.005. Epub 2014 Mar 22. PMID: 32287456; PMCID: PMC7127188.
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Synthesis of amino acid conjugates of glycyrrhizic acid using .

Russian journal of general chemistry

Baltina LA, Fairushina AI, Baltina LA.
PMID: 32288467
Russ J Gen Chem. 2015;85(12):2735-2738. doi: 10.1134/S1070363215120129. Epub 2016 Feb 06.

Synthesis of amino acid conjugates of glycyrrhizic acid with the use of

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Baltina LA, Fairushina AI, Baltina LA. Synthesis of amino acid conjugates of glycyrrhizic acid using . Russ J Gen Chem. 2016;85(12):2735-2738doi: 10.1134/S1070363215120129.
Baltina, L. A., Fairushina, A. I., & Baltina, L. A. (2015). Synthesis of amino acid conjugates of glycyrrhizic acid using . Russian journal of general chemistry, 85(12), 2735-2738. https://doi.org/10.1134/S1070363215120129
Baltina, L A, et al. "Synthesis of amino acid conjugates of glycyrrhizic acid using ." Russian journal of general chemistry vol. 85,12 (2015): 2735-2738. doi: https://doi.org/10.1134/S1070363215120129
Baltina LA, Fairushina AI, Baltina LA. Synthesis of amino acid conjugates of glycyrrhizic acid using . Russ J Gen Chem. 2015;85(12):2735-2738. doi: 10.1134/S1070363215120129. Epub 2016 Feb 06. PMID: 32288467; PMCID: PMC7104134.
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Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Ma Q, Wang Z, Chen R, Lei B, Liu B, Jiang H, Chen Z, Cai X, Guo X, Zhou M, Huang J, Li X, Dai J, Yang Z.
PMID: 34923232
Phytomedicine. 2021 Dec 11;95:153874. doi: 10.1016/j.phymed.2021.153874. Epub 2021 Dec 11.

BACKGROUND: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) pose a huge threat to human public health, no specific treatment is available. Jinzhen granule (JZ) is a traditional eight ingredients-Chinese medicine with prominent efficacy...

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Ma Q, Wang Z, Chen R, et al. Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action. Phytomedicine. 2021;95:153874doi: 10.1016/j.phymed.2021.153874.
Ma, Q., Wang, Z., Chen, R., Lei, B., Liu, B., Jiang, H., Chen, Z., Cai, X., Guo, X., Zhou, M., Huang, J., Li, X., Dai, J., & Yang, Z. (2021). Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action. Phytomedicine : international journal of phytotherapy and phytopharmacology, 95153874. https://doi.org/10.1016/j.phymed.2021.153874
Ma, Qinhai, et al. "Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action." Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 95 (2021): 153874. doi: https://doi.org/10.1016/j.phymed.2021.153874
Ma Q, Wang Z, Chen R, Lei B, Liu B, Jiang H, Chen Z, Cai X, Guo X, Zhou M, Huang J, Li X, Dai J, Yang Z. Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action. Phytomedicine. 2021 Dec 11;95:153874. doi: 10.1016/j.phymed.2021.153874. Epub 2021 Dec 11. PMID: 34923232; PMCID: PMC8665848.
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Immunotherapeutic effects of Glycyrrhiza glabra and Glycyrrhizic Acid on Leishmania major-infection BALB/C mice.

Parasite immunology

Sheikhi S, Khamesipour A, Radjabian T, Ghazanfari T, Miramin Mohammadi A.
PMID: 34559893
Parasite Immunol. 2021 Sep 24;e12879. doi: 10.1111/pim.12879. Epub 2021 Sep 24.

Treatment of cutaneous leishmaniasis (CL) is a public health problem in endemic areas. The objective of the current study was to investigate the immunotherapeutic activities of the hydroalcoholic extract of Glycyrrhiza glabra (HEG) and glycyrrhizic acid (GA) in the...

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Sheikhi S, Khamesipour A, Radjabian T, et al. Immunotherapeutic effects of Glycyrrhiza glabra and Glycyrrhizic Acid on Leishmania major-infection BALB/C mice. Parasite Immunol. 2021;e12879doi: 10.1111/pim.12879.
Sheikhi, S., Khamesipour, A., Radjabian, T., Ghazanfari, T., & Miramin Mohammadi, A. (2021). Immunotherapeutic effects of Glycyrrhiza glabra and Glycyrrhizic Acid on Leishmania major-infection BALB/C mice. Parasite immunology, e12879. https://doi.org/10.1111/pim.12879
Sheikhi, Shima, et al. "Immunotherapeutic effects of Glycyrrhiza glabra and Glycyrrhizic Acid on Leishmania major-infection BALB/C mice." Parasite immunology vol. (2021): e12879. doi: https://doi.org/10.1111/pim.12879
Sheikhi S, Khamesipour A, Radjabian T, Ghazanfari T, Miramin Mohammadi A. Immunotherapeutic effects of Glycyrrhiza glabra and Glycyrrhizic Acid on Leishmania major-infection BALB/C mice. Parasite Immunol. 2021 Sep 24;e12879. doi: 10.1111/pim.12879. Epub 2021 Sep 24. PMID: 34559893.
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Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond.

Bioorganic chemistry

Zhang Q, Wang Y, Wang Z, Mohammed EAH, Zhao Q, He D, Wang Z.
PMID: 34902645
Bioorg Chem. 2021 Dec 06;119:105542. doi: 10.1016/j.bioorg.2021.105542. Epub 2021 Dec 06.

A series of glycyrrhetinic acid (GA, aglycone of glycyrrhizic acid) derivatives containing disulfide bond were synthesized and their anti-inflammatory and anti-fibrosis activities were evaluated in vivo and in vitro. Among them, compound 7 displayed the highest toxicity to all...

Cite
Zhang Q, Wang Y, Wang Z, et al. Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorg Chem. 2021;119:105542doi: 10.1016/j.bioorg.2021.105542.
Zhang, Q., Wang, Y., Wang, Z., Mohammed, E. A. H., Zhao, Q., He, D., & Wang, Z. (2021). Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorganic chemistry, 119105542. https://doi.org/10.1016/j.bioorg.2021.105542
Zhang, Qiuping, et al. "Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond." Bioorganic chemistry vol. 119 (2021): 105542. doi: https://doi.org/10.1016/j.bioorg.2021.105542
Zhang Q, Wang Y, Wang Z, Mohammed EAH, Zhao Q, He D, Wang Z. Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorg Chem. 2021 Dec 06;119:105542. doi: 10.1016/j.bioorg.2021.105542. Epub 2021 Dec 06. PMID: 34902645.
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