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Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins.

ACS chemical biology

Coukos JS, Moellering RE.
PMID: 34581579
ACS Chem Biol. 2021 Nov 19;16(11):2453-2461. doi: 10.1021/acschembio.1c00553. Epub 2021 Sep 28.

Methylglyoxal (MGO) is a reactive byproduct formed by several metabolic precursors, the most notable being triosephosphates in glycolysis. While many MGO-mediated adducts have been described, the reactivity and specific biomolecular targets of MGO remain incompletely mapped. Based on our...

Use of Crown Ether Functions as Secondary Coordination Spheres for the Manipulation of Ligand-Metal Intramolecular Electron Transfer in Copper-Guanidine Complexes.

Chemistry (Weinheim an der Bergstrasse, Germany)

Haaf S, Kaifer E, Wadepohl H, Himmel HJ.
PMID: 33231900
Chemistry. 2021 Jan 13;27(3):829. doi: 10.1002/chem.202004295. Epub 2020 Nov 24.

Invited for the cover of this issue is the group of Hans-Jörg Himmel at Ruprecht-Karls-Universität Heidelberg. The image depicts the electron transfer process using copper complexes with redox-active guanidines. Read the full text of the article at 10.1002/chem.202003469.

Showing 145 to 146 of 146 entries