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Showing 1477 to 1485 of 1485 entries
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Effects of Selenium Supplement on B Lymphocyte Activity in Experimental Autoimmune Thyroiditis Rats.

International journal of endocrinology

Li Y, Zuo X, Hua C, Zhao Y, Pei X, Tian M.
PMID: 34422046
Int J Endocrinol. 2021 Aug 10;2021:9439344. doi: 10.1155/2021/9439344. eCollection 2021.

METHODS: 45 healthy and adult female SD rats were randomly divided into three groups: normal control group, EAT model group, and selenium yeast supplement EAT group. The EAT model rats were induced by subcutaneous injection of porcine thyroglobulin and...

Immune Inhibitory Properties and Therapeutic Prospects of Transforming Growth Factor-Beta and Interleukin 10 in Autoimmune Hepatitis.

Digestive diseases and sciences

Czaja AJ.
PMID: 33835375
Dig Dis Sci. 2021 Apr 09; doi: 10.1007/s10620-021-06968-6. Epub 2021 Apr 09.

Transforming growth factor-beta and interleukin 10 have diverse immune inhibitory properties that have restored homeostatic defense mechanisms in experimental models of autoimmune disease. The goals of this review are to describe the actions of each cytokine, review their investigational...

Circ_0001438 participates in the pathogenesis of preeclampsia via the circ_0001438/miR-942/NLRP3 regulatory network.

Placenta

Li X, Yang R, Xu Y, Zhang Y.
PMID: 33253995
Placenta. 2021 Jan 15;104:40-50. doi: 10.1016/j.placenta.2020.11.005. Epub 2020 Nov 18.

INTRODUCTION: Preeclampsia (PE) is a common pregnancy disorder with multisystem complications. The growing data suggest that circular RNAs (circRNAs) involve in the development of PE. This study proposed to investigate the function and potential mechanisms of circ_0001438 in PE.METHODS:...

Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson's disease.

BMC complementary medicine and therapies

Fathy SM, El-Dash HA, Said NI.
PMID: 33902532
BMC Complement Med Ther. 2021 Apr 26;21(1):130. doi: 10.1186/s12906-021-03298-y.

BACKGROUND: Paraquat, (PQ), an herbicide that can induce Parkinsonian-like symptoms in rodents and humans. The consumption of phytochemical-rich plants can reduce the risk of chronic illnesses such as inflammation and neurodegenerative diseases. The present study aimed to investigate the...

Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non-diabetic rats.

Journal of cosmetic dermatology

Alsarayreh AZ, Oran SA, Shakhanbeh JM.
PMID: 34928525
J Cosmet Dermatol. 2021 Dec 20; doi: 10.1111/jocd.14668. Epub 2021 Dec 20.

AIM: This study assessed the effects of topical application of R. coriaria extract on the rate of wound closure. The rate of wound contraction was used to assess the wound healing efficacy of the R. coriaria fruit methanolic extract.METHODS:...

mRNA-Based Nanomedicinal Products to Address Corneal Inflammation by Interleukin-10 Supplementation.

Pharmaceutics

Gómez-Aguado I, Rodríguez-Castejón J, Beraza-Millor M, Vicente-Pascual M, Rodríguez-Gascón A, Garelli S, Battaglia L, Del Pozo-Rodríguez A, Solinís MÁ.
PMID: 34575548
Pharmaceutics. 2021 Sep 15;13(9). doi: 10.3390/pharmaceutics13091472.

The anti-inflammatory cytokine Interleukin-10 (IL-10) is considered an efficient treatment for corneal inflammation, in spite of its short half-life and poor eye bioavailability. In the present work, mRNA-based nanomedicinal products based on solid lipid nanoparticles (SLNs) were developed in...

Fetal and maternal inflammatory response in the setting of maternal intrapartum fever with and without clinical and histologic chorioamnionitis.

American journal of obstetrics & gynecology MFM

Lagodka S, Petrucci S, Moretti ML, Cabbad M, Lakhi NA.
PMID: 34861429
Am J Obstet Gynecol MFM. 2021 Nov 30;4(2):100539. doi: 10.1016/j.ajogmf.2021.100539. Epub 2021 Nov 30.

BACKGROUND: Both infectious and noninfectious causes of maternal fever have been linked to adverse neonatal outcomes including low Apg0ar scores, respiratory distress, hypotonia, and neonatal seizures. Even in the absence of infection, the occurrence of intrapartum fever is a...

The pharmacogenetic background of hepatitis C treatment.

Mutation research. Reviews in mutation research

Schlecker C, Ultsch A, Geisslinger G, Lötsch J.
PMID: 22409946
Mutat Res Rev Mutat Res. 2012 Jul-Sep;751(1):36-48. doi: 10.1016/j.mrrev.2012.02.001. Epub 2012 Mar 03.

Insufficiently treated hepatitis C virus (HCV) infection remains a major healthcare issue. Individual therapy responses vary considerably from spontaneous clearing of the virus to lethal conditions. Host genetics currently receives a major scientific and clinical interest as an important...

Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms.

Frontiers in cellular neuroscience

Tsetlin V, Haufe Y, Safronova V, Serov D, Shadamarshan P, Son L, Shelukhina I, Kudryavtsev D, Kryukova E, Kasheverov I, Nicke A, Utkin Y.
PMID: 35002625
Front Cell Neurosci. 2021 Dec 23;15:765541. doi: 10.3389/fncel.2021.765541. eCollection 2021.

Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits. While the α7 subtype is widely distributed in the mammalian brain and several...

Showing 1477 to 1485 of 1485 entries