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Showing 157 to 163 of 163 entries
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Splicing modulators: on the way from nature to clinic.

The Journal of antibiotics

Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M.
PMID: 34345042
J Antibiot (Tokyo). 2021 Oct;74(10):603-616. doi: 10.1038/s41429-021-00450-1. Epub 2021 Aug 03.

Over the course of more than two decades, natural products isolated from various microorganisms and plants have built the foundation for chemical biology research into the mechanism of pre-mRNA splicing. Hand in hand with advances in scientific methodology small...

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Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M. Splicing modulators: on the way from nature to clinic. J Antibiot (Tokyo). 2021;74(10):603-616doi: 10.1038/s41429-021-00450-1.
Schneider-Poetsch, T., Chhipi-Shrestha, J. K., & Yoshida, M. (2021). Splicing modulators: on the way from nature to clinic. The Journal of antibiotics, 74(10), 603-616. https://doi.org/10.1038/s41429-021-00450-1
Schneider-Poetsch, Tilman, et al. "Splicing modulators: on the way from nature to clinic." The Journal of antibiotics vol. 74,10 (2021): 603-616. doi: https://doi.org/10.1038/s41429-021-00450-1
Schneider-Poetsch T, Chhipi-Shrestha JK, Yoshida M. Splicing modulators: on the way from nature to clinic. J Antibiot (Tokyo). 2021 Oct;74(10):603-616. doi: 10.1038/s41429-021-00450-1. Epub 2021 Aug 03. PMID: 34345042; PMCID: PMC8472923.
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Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01.

The Journal of antibiotics

Bai Y, Yi P, Zhang Y, Hu J, Wang Y, Ju J, Pan H.
PMID: 34272496
J Antibiot (Tokyo). 2021 Nov;74(11):799-806. doi: 10.1038/s41429-021-00447-w. Epub 2021 Jul 16.

Four new α-pyrone derivatives, named germicidins P-S (1-4) along with nine known analogues (5-13) were discovered from the sponge-associated Streptomyces sp. 18A01 guided by Global Natural Products Social (GNPS) molecular networking, the LC-DAD-MS profile, and hexokinase II (HK2) inhibitory...

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Bai Y, Yi P, Zhang Y, et al. Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01. J Antibiot (Tokyo). 2021;74(11):799-806doi: 10.1038/s41429-021-00447-w.
Bai, Y., Yi, P., Zhang, Y., Hu, J., Wang, Y., Ju, J., & Pan, H. (2021). Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01. The Journal of antibiotics, 74(11), 799-806. https://doi.org/10.1038/s41429-021-00447-w
Bai, Yan, et al. "Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01." The Journal of antibiotics vol. 74,11 (2021): 799-806. doi: https://doi.org/10.1038/s41429-021-00447-w
Bai Y, Yi P, Zhang Y, Hu J, Wang Y, Ju J, Pan H. Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01. J Antibiot (Tokyo). 2021 Nov;74(11):799-806. doi: 10.1038/s41429-021-00447-w. Epub 2021 Jul 16. PMID: 34272496.
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Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases.

The Journal of antibiotics

Adachi H, Nosaka C, Atsumi S, Nakae K, Umezawa Y, Sawa R, Kubota Y, Nakane C, Shibuya M, Nishimura Y.
PMID: 34282315
J Antibiot (Tokyo). 2021 Oct;74(10):734-742. doi: 10.1038/s41429-021-00445-y. Epub 2021 Jul 20.

A series of analogs of vegfrecine, a natural quinone vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, was synthesized via oxidative amination of 2,5-dihydroxybenzamide with functionalized arylamine followed by ammonolysis and substitution of the quinone ring. The inhibitory...

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Adachi H, Nosaka C, Atsumi S, et al. Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases. J Antibiot (Tokyo). 2021;74(10):734-742doi: 10.1038/s41429-021-00445-y.
Adachi, H., Nosaka, C., Atsumi, S., Nakae, K., Umezawa, Y., Sawa, R., Kubota, Y., Nakane, C., Shibuya, M., & Nishimura, Y. (2021). Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases. The Journal of antibiotics, 74(10), 734-742. https://doi.org/10.1038/s41429-021-00445-y
Adachi, Hayamitsu, et al. "Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases." The Journal of antibiotics vol. 74,10 (2021): 734-742. doi: https://doi.org/10.1038/s41429-021-00445-y
Adachi H, Nosaka C, Atsumi S, Nakae K, Umezawa Y, Sawa R, Kubota Y, Nakane C, Shibuya M, Nishimura Y. Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases. J Antibiot (Tokyo). 2021 Oct;74(10):734-742. doi: 10.1038/s41429-021-00445-y. Epub 2021 Jul 20. PMID: 34282315.
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The mechanisms of action of ivermectin against SARS-CoV-2-an extensive review.

The Journal of antibiotics

Zaidi AK, Dehgani-Mobaraki P.
PMID: 34931048
J Antibiot (Tokyo). 2021 Dec 21; doi: 10.1038/s41429-021-00491-6. Epub 2021 Dec 21.

Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the probable mechanisms...

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Zaidi AK, Dehgani-Mobaraki P. The mechanisms of action of ivermectin against SARS-CoV-2-an extensive review. J Antibiot (Tokyo). 2021;doi: 10.1038/s41429-021-00491-6.
Zaidi, A. K., & Dehgani-Mobaraki, P. (2021). The mechanisms of action of ivermectin against SARS-CoV-2-an extensive review. The Journal of antibiotics, . https://doi.org/10.1038/s41429-021-00491-6
Zaidi, Asiya Kamber, and Dehgani-Mobaraki, Puya. "The mechanisms of action of ivermectin against SARS-CoV-2-an extensive review." The Journal of antibiotics vol. (2021). doi: https://doi.org/10.1038/s41429-021-00491-6
Zaidi AK, Dehgani-Mobaraki P. The mechanisms of action of ivermectin against SARS-CoV-2-an extensive review. J Antibiot (Tokyo). 2021 Dec 21; doi: 10.1038/s41429-021-00491-6. Epub 2021 Dec 21. PMID: 34931048; PMCID: PMC8688140.
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The therapeutic potential of mitochondrial toxins.

The Journal of antibiotics

Kawada M, Amemiya M, Yoshida J, Ohishi T.
PMID: 34163026
J Antibiot (Tokyo). 2021 Oct;74(10):696-705. doi: 10.1038/s41429-021-00436-z. Epub 2021 Jun 23.

When screening active compounds by phenotypic assays, we often encounter mitochondrial toxins, which are compounds that can affect mitochondrial functions. In normal cells, these toxins may have relatively low toxicity but can nonetheless show measurable effects even at low...

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Kawada M, Amemiya M, Yoshida J, et al. The therapeutic potential of mitochondrial toxins. J Antibiot (Tokyo). 2021;74(10):696-705doi: 10.1038/s41429-021-00436-z.
Kawada, M., Amemiya, M., Yoshida, J., & Ohishi, T. (2021). The therapeutic potential of mitochondrial toxins. The Journal of antibiotics, 74(10), 696-705. https://doi.org/10.1038/s41429-021-00436-z
Kawada, Manabu, et al. "The therapeutic potential of mitochondrial toxins." The Journal of antibiotics vol. 74,10 (2021): 696-705. doi: https://doi.org/10.1038/s41429-021-00436-z
Kawada M, Amemiya M, Yoshida J, Ohishi T. The therapeutic potential of mitochondrial toxins. J Antibiot (Tokyo). 2021 Oct;74(10):696-705. doi: 10.1038/s41429-021-00436-z. Epub 2021 Jun 23. PMID: 34163026.
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Screening study of cancer-related cellular signals from microbial natural products.

The Journal of antibiotics

Ishibashi M.
PMID: 34193986
J Antibiot (Tokyo). 2021 Oct;74(10):629-638. doi: 10.1038/s41429-021-00434-1. Epub 2021 Jun 30.

To identify bioactive natural products from various natural resources, such as plants and microorganisms, we investigated programs to screen for compounds that affect several cancer-related cellular signaling pathways, such as BMI1, TRAIL, and Wnt. This review summarizes the results...

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Ishibashi M. Screening study of cancer-related cellular signals from microbial natural products. J Antibiot (Tokyo). 2021;74(10):629-638doi: 10.1038/s41429-021-00434-1.
Ishibashi, M. (2021). Screening study of cancer-related cellular signals from microbial natural products. The Journal of antibiotics, 74(10), 629-638. https://doi.org/10.1038/s41429-021-00434-1
Ishibashi, Masami. "Screening study of cancer-related cellular signals from microbial natural products." The Journal of antibiotics vol. 74,10 (2021): 629-638. doi: https://doi.org/10.1038/s41429-021-00434-1
Ishibashi M. Screening study of cancer-related cellular signals from microbial natural products. J Antibiot (Tokyo). 2021 Oct;74(10):629-638. doi: 10.1038/s41429-021-00434-1. Epub 2021 Jun 30. PMID: 34193986.
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Identification of pulvomycin as an inhibitor of the futalosine pathway.

The Journal of antibiotics

Ogasawara Y, Umetsu S, Inahashi Y, Nonaka K, Dairi T.
PMID: 34417567
J Antibiot (Tokyo). 2021 Nov;74(11):825-829. doi: 10.1038/s41429-021-00465-8. Epub 2021 Aug 20.

Menaquinone is an essential cofactor in the electron-transfer pathway for bacteria. Menaquinone is biosynthesized from chorismate using either the well-known canonical pathway established by pioneering studies in model microorganisms or the futalosine pathway, which we discovered in Streptomyces. Because...

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Ogasawara Y, Umetsu S, Inahashi Y, et al. Identification of pulvomycin as an inhibitor of the futalosine pathway. J Antibiot (Tokyo). 2021;74(11):825-829doi: 10.1038/s41429-021-00465-8.
Ogasawara, Y., Umetsu, S., Inahashi, Y., Nonaka, K., & Dairi, T. (2021). Identification of pulvomycin as an inhibitor of the futalosine pathway. The Journal of antibiotics, 74(11), 825-829. https://doi.org/10.1038/s41429-021-00465-8
Ogasawara, Yasushi, et al. "Identification of pulvomycin as an inhibitor of the futalosine pathway." The Journal of antibiotics vol. 74,11 (2021): 825-829. doi: https://doi.org/10.1038/s41429-021-00465-8
Ogasawara Y, Umetsu S, Inahashi Y, Nonaka K, Dairi T. Identification of pulvomycin as an inhibitor of the futalosine pathway. J Antibiot (Tokyo). 2021 Nov;74(11):825-829. doi: 10.1038/s41429-021-00465-8. Epub 2021 Aug 20. PMID: 34417567.
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Showing 157 to 163 of 163 entries