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Showing 13 to 24 of 236 entries
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Platycarya strobilacea Sieb. et Zucc.: a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology.

The Journal of pharmacy and pharmacology

Zhao P, Han L, Wang Y, Qiu J, Zhang X, Tang Z, Duan X, Song X.
PMID: 34387671
J Pharm Pharmacol. 2021 Aug 13; doi: 10.1093/jpp/rgab110. Epub 2021 Aug 13.

OBJECTIVES: Platycarya strobilacea Sieb. et Zucc. is the dry infructescence of P. strobilacea, a Juglandaceae plant and is a traditional Chinese medicine with great development potential and utilization value. This study summarizes the research progress on the traditional uses,...

Pinus roxburghii alleviates bone porosity and loss in postmenopausal osteoporosis by regulating estrogen, calcium homeostasis and receptor activator of nuclear factor-κB, osteoprotegerin, cathepsin bone markers.

The Journal of pharmacy and pharmacology

Sharma A, Sharma L, Saini RV, Kumar A, Goyal R.
PMID: 33769535
J Pharm Pharmacol. 2021 Jun 08;73(7):901-915. doi: 10.1093/jpp/rgaa014.

OBJECTIVES: The study was aimed to evaluate the potential of hydroalcoholic extract of Pinus roxburghii (PRE) stem bark in post-menopausal osteoporosis and its underlying mechanisms.METHODS: In silico docking of the markers was done using AutoDock version 4.2. for molecular...

Short overview on the relevance of microRNA-reactive oxygen species (ROS) interactions and lipid peroxidation for modulation of oxidative stress-mediated signalling pathways in cancer treatment.

The Journal of pharmacy and pharmacology

Ulker OC, Panieri E, Suzen S, Jaganjac M, Zarkovic N, Saso L.
PMID: 33769543
J Pharm Pharmacol. 2021 Mar 26; doi: 10.1093/jpp/rgab045. Epub 2021 Mar 26.

OBJECTIVES: Modulation of oxidative stress-mediated signalling pathways is constantly getting more attention as a valuable therapeutic strategy in cancer treatment. Although complexity of redox signalling pathways might represent a major hurdle, the development of advanced -omics technologies allow thorough...

Down-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus suppresses OVCAR-3 cells proliferation and induction of apoptosis by Wnt/β-catenin.

The Journal of pharmacy and pharmacology

Sun L, Cui Y, Jiang K, Li J.
PMID: 33772549
J Pharm Pharmacol. 2021 Aug 12;73(9):1212-1217. doi: 10.1093/jpp/rgab042.

OBJECTIVES: Ovarian cancer is a lethal gynecological malignancy. Long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) was reported to have a critical role in cancer advancement. The ANRIL-mediated oncogenic underlying molecular mechanisms are not fully...

The effects and the mechanisms of naringenin from Artemisia ordosica Krasch on allergic rhinitis based on mast cell degranulation model and network pharmacology.

The Journal of pharmacy and pharmacology

Niu Y, She Z, Su C, Zhao Q, Wang S, Xiao B.
PMID: 34969089
J Pharm Pharmacol. 2021 Dec 30; doi: 10.1093/jpp/rgab166. Epub 2021 Dec 30.

OBJECTIVES: The ethyl acetate extraction of Artemisia ordosica Krasch (AOK) root showed anti-allergic rhinitis (AR) effect, while the active compounds and pharmacological targets were unknown.METHODS: The P815 degranulation was established by cell counting kit 8 assay, β-hexosaminidase releasing assay...

Three-dimensional printed personalized drug devices with anatomical fit: a review.

The Journal of pharmacy and pharmacology

Pinho LAG, Gratieri T, Gelfuso GM, Marreto RN, Cunha-Filho M.
PMID: 34665263
J Pharm Pharmacol. 2021 Oct 19; doi: 10.1093/jpp/rgab146. Epub 2021 Oct 19.

OBJECTIVES: Three-dimensional printing (3DP) has opened the era of drug personalization, promising to revolutionize the pharmaceutical field with improvements in efficacy, safety and compliance of the treatments. As a result of these investigations, a vast therapeutic field has opened...

Study of the cardioprotective effects of crocin on Human Cardiac Myocyte cells and reduction of oxidative stress produced by aluminum phosphide poisoning.

The Journal of pharmacy and pharmacology

Naddafi M, Eghbal MA, Ghazi-Khansari M, Sattari MR, Azarmi Y.
PMID: 33793778
J Pharm Pharmacol. 2021 Oct 07;73(11):1539-1546. doi: 10.1093/jpp/rgaa066.

OBJECTIVES: The effects of Crocin as a cardioprotective material against Aluminum phosphide poisoning by reducing the oxidative stress is investigated.METHODS: The level of biomarkers of oxidative stress (Catalase, Superoxide dismutase, Malondialdehyde and Protein carbonyl) were measured in the cell...

Neuroprotective effects of synthetic borneol and natural borneol based on the neurovascular unit against cerebral ischaemic injury.

The Journal of pharmacy and pharmacology

Xie Q, Li J, Dong T, Yuan J, Lu D, Ma R, Li H, Li Y, Ren M, Chen H, Wang J.
PMID: 34888686
J Pharm Pharmacol. 2021 Dec 09; doi: 10.1093/jpp/rgab167. Epub 2021 Dec 09.

OBJECTIVES: Natural borneol and synthetic borneol were commonly used to treat ischaemic stroke in clinical practice. This study evaluated their different neuroprotective effects on the remodelling and repair of the neurovascular unit (NVU) after cerebral ischaemia.METHODS: We evaluated the...

Insulinotropic and antidiabetic properties of Eucalyptus citriodora leaves and isolation of bioactive phytomolecules.

The Journal of pharmacy and pharmacology

Ansari P, Flatt PR, Harriott P, Abdel-Wahab YHA.
PMID: 33755147
J Pharm Pharmacol. 2021 Jul 07;73(8):1049-1061. doi: 10.1093/jpp/rgab030.

OBJECTIVE: The aim of this study was to delineate the mechanisms of action of the plant Eucalyptus citriodora used traditionally for the treatment of type 2 diabetes.METHODS: Insulin secretion and signal transduction were measured using clonal pancreatic β-cells and...

Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder.

The Journal of pharmacy and pharmacology

Luhach K, Kulkarni GT, Singh VP, Sharma B.
PMID: 34459916
J Pharm Pharmacol. 2021 Oct 07;73(11):1460-1469. doi: 10.1093/jpp/rgab115.

OBJECTIVES: Autism spectrum disorder (ASD) is categorized as a neurodevelopmental disorder, presenting with a variety of aetiological and phenotypical features. Inhibiting the enzyme phosphodiesterase-3 (PDE3) with cilostazol is known to produce beneficial effects in several brain disorders. The pharmacological...

Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties.

The Journal of pharmacy and pharmacology

Kose D, Un H, Ugan RA, Halici Z, Cadirci E, Tastan TB, Kahramanlar A.
PMID: 34160038
J Pharm Pharmacol. 2021 Sep 07;73(10):1302-1309. doi: 10.1093/jpp/rgab088.

OBJECTIVES: We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.METHODS: A total of 40 rats were divided into 5 groups...

Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis.

The Journal of pharmacy and pharmacology

Sun Q, Liang R, Li M, Zhou H.
PMID: 34850057
J Pharm Pharmacol. 2021 Nov 25; doi: 10.1093/jpp/rgab161. Epub 2021 Nov 25.

OBJECTIVES: Circular RNAs (circRNAs) have been demonstrated to play important roles in acute pancreatitis (AP). Herein, this study aimed to investigate the role and mechanism of circRNAs utrophin (circ_UTRN) in AP.METHODS: In vitro cultured rat pancreatic acinar cell line...

Showing 13 to 24 of 236 entries