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Showing 1081 to 1091 of 1091 entries
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Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma.

JAMA oncology

Hirsch L, Martinez Chanza N, Farah S, Xie W, Flippot R, Braun DA, Rathi N, Thouvenin J, Collier KA, Seront E, de Velasco G, Dzimitrowicz H, Beuselinck B, Xu W, Bowman IA, Lam ET, Abuqayas B, Bilen MA, Varkaris A, Zakharia Y, Harrison MR, Mortazavi A, Barthélémy P, Agarwal N, McKay RR, Brastianos PK, Krajewski KM, Albigès L, Harshman LC, Choueiri TK.
PMID: 34673916
JAMA Oncol. 2021 Dec 01;7(12):1815-1823. doi: 10.1001/jamaoncol.2021.4544.

IMPORTANCE: Patients with brain metastases from renal cell carcinoma (RCC) have been underrepresented in clinical trials, and effective systemic therapy is lacking. Cabozantinib shows robust clinical activity in metastatic RCC, but its effect on brain metastases remains unclear.OBJECTIVE: To...

Say Hi.

JAMA oncology

Zhang E.
PMID: 34647968
JAMA Oncol. 2021 Dec 01;7(12):1907. doi: 10.1001/jamaoncol.2021.4315.

No abstract available.

Treatment Outcomes and Safety of Mobocertinib in Platinum-Pretreated Patients With EGFR Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer: A Phase 1/2 Open-label Nonrandomized Clinical Trial.

JAMA oncology

Zhou C, Ramalingam SS, Kim TM, Kim SW, Yang JC, Riely GJ, Mekhail T, Nguyen D, Garcia Campelo MR, Felip E, Vincent S, Jin S, Griffin C, Bunn V, Lin J, Lin HM, Mehta M, Jänne PA.
PMID: 34647988
JAMA Oncol. 2021 Dec 01;7(12):e214761. doi: 10.1001/jamaoncol.2021.4761. Epub 2021 Dec 16.

IMPORTANCE: Metastatic non-small cell lung cancer (mNSCLC) with EGFR exon 20 insertion (EGFRex20ins) mutations is associated with a poor prognosis. Mobocertinib is an oral tyrosine kinase inhibitor designed to selectively target EGFRex20ins mutations.OBJECTIVE: To evaluate treatment outcomes and safety...

American College of Surgeons Efforts in Support of Value-Based Metrics.

JAMA oncology

Nelson H, Ko CY, Hoyt DB.
PMID: 33300947
JAMA Oncol. 2021 Feb 01;7(2):307-308. doi: 10.1001/jamaoncol.2020.6462.

No abstract available.

Data Errors in the Table and Results.

JAMA oncology

[No authors listed]
PMID: 33300961
JAMA Oncol. 2021 Feb 01;7(2):312. doi: 10.1001/jamaoncol.2020.7104.

No abstract available.

Efficacy of Pazopanib With or Without Gemcitabine in Patients With Anthracycline- and/or Ifosfamide-Refractory Soft Tissue Sarcoma: Final Results of the PAPAGEMO Phase 2 Randomized Clinical Trial.

JAMA oncology

Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A.
PMID: 33355646
JAMA Oncol. 2021 Feb 01;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564.

IMPORTANCE: Pazopanib and gemcitabine have shown good tolerability, albeit modest single-agent activity in pretreated soft tissue sarcoma. A combined regimen to improve outcomes is required.OBJECTIVE: To determine the efficacy of gemcitabine and pazopanib compared with pazopanib alone.DESIGN, SETTING, AND...

Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set: An International Agency for Research on Cancer TP53 Database Analysis.

JAMA oncology

Kratz CP, Freycon C, Maxwell KN, Nichols KE, Schiffman JD, Evans DG, Achatz MI, Savage SA, Weitzel JN, Garber JE, Hainaut P, Malkin D.
PMID: 34709361
JAMA Oncol. 2021 Dec 01;7(12):1800-1805. doi: 10.1001/jamaoncol.2021.4398.

IMPORTANCE: Li-Fraumeni syndrome is a cancer predisposition syndrome that is associated with a high, lifelong risk of a broad spectrum of cancers that is caused by pathogenic TP53 germline variants. A definition that reflects the broad phenotypic spectrum that...

Antibody Response to COVID-19 Vaccination in Adults With Hematologic Malignant Disease.

JAMA oncology

Ollila TA, Lu S, Masel R, Zayac A, Paiva K, Rogers RD, Olszewski AJ.
PMID: 34379085
JAMA Oncol. 2021 Nov 01;7(11):1714-1716. doi: 10.1001/jamaoncol.2021.4381.

No abstract available.

Changes in Prostate-Specific Antigen Testing Relative to the Revised US Preventive Services Task Force Recommendation on Prostate Cancer Screening.

JAMA oncology

Leapman MS, Wang R, Park H, Yu JB, Sprenkle PC, Cooperberg MR, Gross CP, Ma X.
PMID: 34762100
JAMA Oncol. 2021 Nov 11; doi: 10.1001/jamaoncol.2021.5143. Epub 2021 Nov 11.

IMPORTANCE: In April 2017, the US Preventive Services Task Force (USPSTF) published a draft guideline that reversed its 2012 guidance advising against prostate-specific antigen (PSA)-based screening for prostate cancer in all men (grade D), instead endorsing individual decision-making for...

Clinical Trial Enrollment of Racial, Ethnic, and Underrepresented Groups-Leveraging a Digital Infrastructure.

JAMA oncology

Culbert M, Oladeru OT.
PMID: 34351362
JAMA Oncol. 2021 Oct 01;7(10):1447-1448. doi: 10.1001/jamaoncol.2021.2680.

No abstract available.

Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II): The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial.

JAMA oncology

Siva S, Bressel M, Mai T, Le H, Vinod S, de Silva H, Macdonald S, Skala M, Hardcastle N, Rezo A, Pryor D, Gill S, Higgs B, Wagenfuehr K, Montgomery R, Awad R, Chesson B, Eade T, Wong W, Sasso G, De Abreu Lourenco R, Kron T, Ball D, Neeson P.
PMID: 34455431
JAMA Oncol. 2021 Oct 01;7(10):1476-1485. doi: 10.1001/jamaoncol.2021.2939.

IMPORTANCE: Evidence is lacking from randomized clinical trials to guide the optimal approach for stereotactic ablative body radiotherapy (SABR) in patients with pulmonary oligometastases.OBJECTIVE: To assess whether single-fraction or multifraction SABR is more effective for the treatment of patients...

Showing 1081 to 1091 of 1091 entries