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Showing 25 to 36 of 483 entries
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[In vitro resistance to fluconazole and itraconazole in clinical isolates of Candida spp and Cryptococcus neoformans].

Revista iberoamericana de micologia

Carrillo Muñoz AJ, Tur C, Estivill D, Montsant L, Carceller A, Hernández-Molina JM, Torres Rodríguez JM.
PMID: 16854170
Rev Iberoam Micol. 1997 Jun;14(2):50-4.

An in vitro susceptibility testing of 181 strains of six species of Candida and 21 strains of Cryptococcus neoformans was carried out in order to investigate the resistance to new antifungal drugs. We have studied clinical isolates from 200...

Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism.

Drug metabolism and pharmacokinetics

Baba T, Touchi A, Ito K, Yamaguchi Y, Yamazoe Y, Ohno Y, Sugiyama Y.
PMID: 15618707
Drug Metab Pharmacokinet. 2002;17(6):522-31. doi: 10.2133/dmpk.17.522.

To investigate whether the free-drug theory is accurate in that only unbound drug is available for drug metabolism or enzyme inhibition. The effect of addition of rat liver cytosol to an in vitro system using human liver microsomes was...

Teratogenicity in vitro-A comparative study of four antimycotic drugs using the whole-embryo culture system.

Toxicology in vitro : an international journal published in association with BIBRA

Bechter R, Schmid BP.
PMID: 20702373
Toxicol In Vitro. 1987;1(1):11-5. doi: 10.1016/0887-2333(87)90032-4.

The embryotoxic effects caused in vitro by the four antimycotic compounds griseofulvin, ketoconazole, naftifine and terbinafine were compared. Rat embryos (9.5 days old) were cultivated in rat serum for 48 hr both in the presence and in the absence...

Comparative study of oral and topical ketoconazole therapy in pityriasis versicolor.

Indian journal of dermatology, venereology and leprology

Nagpal VB, Jain VK, Aggarwal K.
PMID: 17642914
Indian J Dermatol Venereol Leprol. 2003 Jul-Aug;69(4):287-8.

INTRODUCTION: Both topical and systemic ketoconazole are reported to be effective against pityriasis versicolor.MATERIAL AND METHODS: Forty patients suffering from pityriasis versicolor were treated either with oral ketoconazole 200 mg per day or 2% ketoconazole cream topically once daily...

[Separation of ketoconazole enantiomers using high performance liquid chromatography with chiral mobile phase additives].

Se pu = Chinese journal of chromatography

Liu A, Ge W, Wu S, Xu Q, Wang M, Yin X.
PMID: 19626858
Se Pu. 2009 Mar;27(2):240-3.

A simple and effective method for the separation of ketoconazole enantiomers was developed using the chiral mobile phase additive on a C18 reversed-phase column. Several beta-cyclodextrins were investigated as chiral mobile phase additives separately. The results showed that ketoconazole...

Myopathy Associated With HMG-CoA Reductase Inhibitors (Statins): A Series of 10 Patients and Review of the Literature.

Journal of clinical neuromuscular disease

McKelvie PA, Dennett X.
PMID: 19078671
J Clin Neuromuscul Dis. 2002 Jun;3(4):143-8. doi: 10.1097/00131402-200206000-00002.

OBJECTIVE: To examine the clinical profile of patients with myotoxicity due to HMG-CoA reductase inhibitors and the pathological features in the biopsies.DESIGN: All patients receiving HMG-CoA reductase inhibitors who underwent muscle biopsy at the State Neuropathology Service, Melbourne, from...

Comparative study of topical terbinafine and topical ketoconazole in pityriasis versicolor.

Indian journal of dermatology, venereology and leprology

Chopra V, Jain VK.
PMID: 20877107
Indian J Dermatol Venereol Leprol. 2000 Nov-Dec;66(6):299-300.

Fifty patients suffering from pityriasis versicolor were treated with either 2% ketoconazole cream (25 patients) or 1% terbinafine cream (25 patients). Diagnosis was confirmed by microscopic potassium hydroxide (KOH) examination and either of the cream was applied once daily...

Comparison of the activities of four antifungal agents in an in vitro model of dermatophyte nail infection.

Indian journal of dermatology

Nowrozi H, Nazeri G, Adimi P, Bashashati M, Emami M.
PMID: 19882010
Indian J Dermatol. 2008;53(3):125-8. doi: 10.4103/0019-5154.43216.

BACKGROUND: Onychomycosis is a difficult condition to treat and cure rates are disappointing. Moreover fungicidal action of antifungal agents in NCCLS assays and their rapid accumulation in nails in vivo are not compatible with the duration of treatment.AIMS: This...

Enhanced Interaction between Warfarin and High-Dose Ketoconazole: A Case Report.

Case reports in medicine

Jackevicius CA, Ton MN.
PMID: 20029646
Case Rep Med. 2009;2009:315687. doi: 10.1155/2009/315687. Epub 2009 Dec 09.

This case describes the increased anticoagulation effect associated with the use of high-dose ketoconazole. A 59-year-old man treated with warfarin for aortic valve replacement was prescribed high-dose ketoconazole and hydrocortisone for the treatment of prostate cancer. Despite lowering the...

Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp. leaves and roots ethanolic extracts and conventional antifungals.

Pharmacognosy magazine

Brito SA, Rodrigues FF, Campos AR, da Costa JG.
PMID: 22701281
Pharmacogn Mag. 2012 Apr;8(30):103-6. doi: 10.4103/0973-1296.96550.

BACKGROUND: The use and investigation of natural products with antimicrobial activity from vegeral source have been reported by several researchers. Cajanus cajan (Fabaceae) is a multiple use specie mainly as human food. In popular medicine, diverse parts of the...

Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.

Oncology reports

Li Q, Bever C.
PMID: 21590232
Oncol Rep. 1997 Nov-Dec;4(6):1255-60. doi: 10.3892/or.4.6.1255.

Cathepsin B (CB), a lysosomal cysteine proteinase, is implicated in tumour invasion and metastasis. Although direct exposure of THP-1 cells to arachidonic acid did not stimulate the induction of CB activity, cells treated with arachidonic acid followed by interferon-gamma...

Determination of antifungal susceptibility patterns among the clinical isolates of Candida species.

Journal of global infectious diseases

Zomorodian K, Rahimi MJ, Pakshir K, Motamedi M, Ghiasi MR, Rezashah H.
PMID: 22223999
J Glob Infect Dis. 2011 Oct;3(4):357-60. doi: 10.4103/0974-777X.91059.

CONTEXT: Candida species are opportunistic yeasts that cause infections ranging from simple dermatosis to potentially life-threatening fungemia. The emergence of resistance to antifungal drugs has been increased in the past two decades.AIM: the present study we determined to find...

Showing 25 to 36 of 483 entries