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Showing 4897 to 4904 of 4904 entries
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Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Carotti S, Lettieri-Barbato D, Piemonte F, Ruggiero S, Rosina M, Zalfa F, Zingariello M, Arciprete F, Valentini F, Francesconi M, D'Amico J, De Vincentis A, Baiocchini A, Perrone G, Antonelli-Incalzi R, Morini S, Picardi A, Aquilano K, Vespasiani-Gentilucci U.
PMID: 34795230
Cell Death Dis. 2021 Nov 18;12(12):1092. doi: 10.1038/s41419-021-04382-4.

Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein content and activity in in vitro and in vivo models of fat overload and...

Lipid Transport in Brown Adipocyte Thermogenesis.

Frontiers in physiology

Wade G, McGahee A, Ntambi JM, Simcox J.
PMID: 35002769
Front Physiol. 2021 Dec 23;12:787535. doi: 10.3389/fphys.2021.787535. eCollection 2021.

Non-shivering thermogenesis is an energy demanding process that primarily occurs in brown and beige adipose tissue. Beyond regulating body temperature, these thermogenic adipocytes regulate systemic glucose and lipid homeostasis. Historically, research on thermogenic adipocytes has focused on glycolytic metabolism...

The impact of CIEDs with automatic "wireless" remote monitoring on efficiency.

Pacing and clinical electrophysiology : PACE

Dechert BE, Bradley DJ, Serwer GA, LaPage MJ.
PMID: 34351650
Pacing Clin Electrophysiol. 2021 Oct;44(10):1671-1674. doi: 10.1111/pace.14333. Epub 2021 Aug 19.

BACKGROUND: A benefit of automatically transmitting or "wireless" CIEDs (W-CIED) is the prompt detection of device malfunction and arrhythmias. We hypothesized that the use of W-CIEDs would improve the efficiency of remote monitoring by decreasing unnecessary CIED remote transmissions...

Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review.

Frontiers in immunology

Hryhorowicz S, Kaczmarek-Ryś M, Zielińska A, Scott RJ, Słomski R, Pławski A.
PMID: 35003109
Front Immunol. 2021 Dec 22;12:790803. doi: 10.3389/fimmu.2021.790803. eCollection 2021.

Inflammatory bowel disease (IBD) is a general term used to describe a group of chronic inflammatory conditions of the gastrointestinal tract of unknown etiology, including two primary forms: Crohn's disease (CD) and ulcerative colitis (UC). The endocannabinoid system (ECS)...

The paracrine effects of adipocytes on lipid metabolism in doxorubicin-treated triple negative breast cancer cells.

Adipocyte

Mentoor I, Engelbrecht AM, van de Vyver M, van Jaarsveld PJ, Nell T.
PMID: 34812105
Adipocyte. 2021 Dec;10(1):505-523. doi: 10.1080/21623945.2021.1979758.

Adipocytes in the breast tumour microenvironment promotes acquired treatment resistance. We used an in vitro adipocyte-conditioned media approach to investigate the direct paracrine effects of adipocyte secretory factors on MDA-MB-231 breast cancer cells treated with doxorubicin to clarify the...

Application of Rhizomucor miehei lipase-displaying Pichia pastoris whole cell for biodiesel production using agro-industrial residuals as substrate.

International journal of biological macromolecules

Sena RO, Carneiro C, Moura MVH, Brêda GC, Pinto MCC, Fé LXSGM, Fernandez-Lafuente R, Manoel EA, Almeida RV, Freire DMG, Cipolatti EP.
PMID: 34455007
Int J Biol Macromol. 2021 Oct 31;189:734-743. doi: 10.1016/j.ijbiomac.2021.08.173. Epub 2021 Aug 27.

This work aimed the application of a new biocatalyst for biodiesel production from residual agro-industrial fatty acids. A recombinant Pichia pastoris displaying lipase from Rhizomucor miehei (RML) on the cell surface, using the PIR-1 anchor system, were prepared using...

Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.

Frontiers in cell and developmental biology

Liu H, Zhou C, Qi D, Gao Y, Zhu M, Tao T, Sun X, Xiao J.
PMID: 33777947
Front Cell Dev Biol. 2021 Mar 12;9:640867. doi: 10.3389/fcell.2021.640867. eCollection 2021.

Osteoporosis is a common chronic metabolic bone disease characterized by reduced trabecular bone and increased bone fragility. Monoacylglycerol lipase (MAGL) is a lipolytic enzyme to catalyze the hydrolysis of monoglycerides and specifically degrades the 2-arachidonoyl glycerol (2-AG). Previous studies...

Complex coacervates as extraction media.

Green chemistry : an international journal and green chemistry resource : GC

van Lente J, Pazos Urrea M, Brouwer T, Schuur B, Lindhoud S.
PMID: 34456626
Green Chem. 2021 Jul 02;23(16):5812-5824. doi: 10.1039/d1gc01880a. eCollection 2021 Aug 16.

Various solvents such as ionic liquids, deep eutectic solvents, and aqueous two phase systems have been suggested as greener alternatives to existing extraction processes. We propose to add macroscopic complex coacervates to this list. Complex coacervates are liquid-like forms...

Showing 4897 to 4904 of 4904 entries