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Showing 13 to 24 of 32 entries
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Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.

Clinical epidemiology

Khalid S, Calderon-Larrañaga S, Hawley S, Ali MS, Judge A, Arden N, van Staa T, Cooper C, Javaid MK, Prieto-Alhambra D.
PMID: 30349390
Clin Epidemiol. 2018 Oct 09;10:1417-1431. doi: 10.2147/CLEP.S164112. eCollection 2018.

PURPOSE: This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice.MATERIALS AND METHODS: We investigated two primary care records databases covering UK...

The Impact of Lumbar Spinal Stenosis, Knee Osteoarthritis, and Loss of Lumbar Lordosis on the Quality of Life: Findings from the Katsuragi Low Back Pain Study.

Spine surgery and related research

Ishimoto Y, Kawakami M, Curtis E, Cooper C, Harvey NC, Westbury L, Teraguchi M, Horie K, Nakagawa Y.
PMID: 31435569
Spine Surg Relat Res. 2018 Aug 25;3(2):157-162. doi: 10.22603/ssrr.2018-0051. eCollection 2019 Apr 27.

INTRODUCTION: Musculoskeletal diseases and spinal malalignment are associated with poorer quality of life (QOL) in the elderly. However, to date, few general population cohort studies have focused on these conditions together. Our objectives were to clarify the associations between...

Poor sleep quality and physical performance in older adults.

Sleep health

Denison HJ, Jameson KA, Sayer AA, Patel HP, Edwards MH, Arora T, Dennison EM, Cooper C, Baird J.
PMID: 33223446
Sleep Health. 2021 Apr;7(2):205-211. doi: 10.1016/j.sleh.2020.10.002. Epub 2020 Nov 20.

OBJECTIVES: This study aimed to examine the association between sleep quality and physical performance among a group of UK community-dwelling older adults, according to sex.METHODS: Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Physical performance was assessed...

Exploring the views of stakeholders about the feasibility of carrying out a randomised controlled trial of Individual Placement and Support for people unemployed with chronic pain based in primary care (the InSTEP study).

Pilot and feasibility studies

Holmes MM, Stanescu SC, Linaker C, Price C, Maguire N, Fraser S, Cooper C, Walker-Bone K.
PMID: 32280484
Pilot Feasibility Stud. 2020 Apr 04;6:44. doi: 10.1186/s40814-020-00588-z. eCollection 2020.

BACKGROUND: Individual Placement and Support (IPS) is a model of vocational rehabilitation originally developed to help people with severe mental illness obtain and maintain employment. Work disability is common amongst people with chronic pain conditions, yet few effective interventions...

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.

Nature genetics

Luciano M, Hagenaars SP, Davies G, Hill WD, Clarke TK, Shirali M, Harris SE, Marioni RE, Liewald DC, Fawns-Ritchie C, Adams MJ, Howard DM, Lewis CM, Gale CR, McIntosh AM, Deary IJ.
PMID: 29255261
Nat Genet. 2018 Jan;50(1):6-11. doi: 10.1038/s41588-017-0013-8. Epub 2017 Dec 18.

Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt)

Associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact physical activity in later life.

Preventive medicine reports

Elhakeem A, Hannam K, Deere KC, Hartley A, Clark EM, Moss C, Edwards MH, Dennison E, Gaysin T, Kuh D, Wong A, Fox KR, Cooper C, Cooper R, Tobias JH.
PMID: 29134173
Prev Med Rep. 2017 Oct 25;8:183-189. doi: 10.1016/j.pmedr.2017.10.011. eCollection 2017 Dec.

High impact physical activity (PA) is thought to benefit bone. We examined associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact and overall PA in later life. Data were from 848 participants (66.2% female, mean age...

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice.

Nature genetics

Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB.
PMID: 30988516
Nat Genet. 2019 May;51(5):920. doi: 10.1038/s41588-019-0415-x.

In the version of this article initially published, in Fig. 5a, the data in the right column of 'DAAM2 gRNA1' were incorrectly plotted as circles indicating 'untreated' rather than as squares indicating 'treated'. The error has been corrected in...

Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts.

Royal Society open science

Bateson M, Aviv A, Bendix L, Benetos A, Ben-Shlomo Y, Bojesen SE, Cooper C, Cooper R, Deary IJ, Hägg S, Harris SE, Kark JD, Kronenberg F, Kuh D, Labat C, Martin-Ruiz CM, Meyer C, Nordestgaard BG, Penninx BWJH, Pepper GV, Révész D, Said MA, Starr JM, Syddall H, Thomson WM, van der Harst P, Whooley M, von Zglinicki T, Willeit P, Zhan Y, Nettle D.
PMID: 31312500
R Soc Open Sci. 2019 Jun 05;6(6):190420. doi: 10.1098/rsos.190420. eCollection 2019 Jun.

Smoking is associated with shorter leucocyte telomere length (LTL), a biomarker of increased morbidity and reduced longevity. This association is widely interpreted as evidence that smoking causes accelerated LTL attrition in adulthood, but the evidence for this is inconsistent....

Renin-Angiotensin-Aldosterone System Blockers Are Not Associated With Coronavirus Disease 2019 (COVID-19) Hospitalization: Study of 1,439 UK Biobank Cases.

Frontiers in cardiovascular medicine

Raisi-Estabragh Z, McCracken C, Ardissino M, Bethell MS, Cooper J, Cooper C, Harvey NC, Petersen SE.
PMID: 32766285
Front Cardiovasc Med. 2020 Jul 14;7:138. doi: 10.3389/fcvm.2020.00138. eCollection 2020.

No abstract available.

Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank.

Frontiers in endocrinology

Clynes MA, Jameson K, Prieto-Alhambra D, Harvey NC, Cooper C, Dennison EM.
PMID: 31849841
Front Endocrinol (Lausanne). 2019 Nov 26;10:817. doi: 10.3389/fendo.2019.00817. eCollection 2019.

No abstract available.

How well do national and local policies in England relevant to maternal and child health meet the international standard for non-communicable disease prevention? A policy analysis.

BMJ open

Penn-Newman D, Shaw S, Congalton D, Strommer S, Morris T, Lawrence W, Chase D, Cooper C, Barker M, Baird J, Inskip H, Vogel C.
PMID: 30420345
BMJ Open. 2018 Nov 12;8(11):e022062. doi: 10.1136/bmjopen-2018-022062.

OBJECTIVES: (1) To identify national policies for England and local policies for Southampton City that are relevant to maternal and child health. (2) To quantify the extent to which these policies meet the international standards for nutrition and physical...

Pharmacologic intervention for prevention of fractures in osteopenic and osteoporotic postmenopausal women: Systemic review and meta-analysis.

Bone reports

Wu CH, Hung WC, Chang IL, Tsai TT, Chang YF, McCloskey EV, Watts NB, McClung MR, Huang CF, Chen CH, Wu KL, Tsai KS, Chan DC, Chen JF, Tu ST, Hwang JS, Xia W, Matsumoto T, Chung YS, Cooper C, Kanis JA, Yang RS, Chan WP.
PMID: 33195764
Bone Rep. 2020 Oct 27;13:100729. doi: 10.1016/j.bonr.2020.100729. eCollection 2020 Dec.

OBJECTIVES: Emerging evidence has indicated a role for pharmacologic agents in the primary prevention of osteoporotic fracture, but have not yet been systematically reviewed for meta-analysis. We conducted a meta-analysis to evaluate the efficacy of pharmacologic interventions in reducing...

Showing 13 to 24 of 32 entries