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Showing 85 to 86 of 86 entries
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Novel Antimuscarinic Antidepressant-like Compounds with Reduced Effects on Cognition.

The Journal of pharmacology and experimental therapeutics

Johnson CR, Kangas BD, Jutkiewicz EM, Winger G, Bergman J, Coop A, Woods JH.
PMID: 33712507
J Pharmacol Exp Ther. 2021 Jun;377(3):336-345. doi: 10.1124/jpet.120.000337. Epub 2021 Mar 12.

The cholinergic nervous system has been implicated in mood disorders, evident in the fast-onset antidepressant effects of scopolamine, a potent muscarinic antagonist, in clinical studies. One prominent disadvantage of the use of scopolamine in the treatment of depression is...

Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease.

Journal of experimental pharmacology

Ora J, Coppola A, Cazzola M, Calzetta L, Rogliani P.
PMID: 33324119
J Exp Pharmacol. 2020 Dec 08;12:559-574. doi: 10.2147/JEP.S259330. eCollection 2020.

INTRODUCTION: Bronchodilators are the cornerstone of chronic obstructive pulmonary disease (COPD) therapy and long-acting muscarinic antagonists (LAMAs) as a mono or combination treatment play a pivotal role. Several LAMAs are already available on the market in different formulations, but...

Showing 85 to 86 of 86 entries