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Showing 289 to 297 of 297 entries
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GABA.

Neurobiology of aging

Hu B, Geng C, Guo F, Liu Y, Zong YC, Hou XY.
PMID: 34507271
Neurobiol Aging. 2021 Dec;108:47-57. doi: 10.1016/j.neurobiolaging.2021.08.003. Epub 2021 Aug 09.

Olfactory damage develops at the early stages of Alzheimer's disease (AD). While amyloid-β (Aβ) oligomers are shown to impair inhibitory circuits in the olfactory bulb (OB), its underlying mechanisms remain unclear. Here, we investigated the olfactory dysfunction due to...

An Inescapable Cat Odor Exposure Protocol for Studying Innate and Contextual Threat Conditioning in Rats.

Journal of visualized experiments : JoVE

Rodríguez M, Contreras M, Domic-Siede M, Ceric F, Torrealba F.
PMID: 34842235
J Vis Exp. 2021 Nov 10;(177). doi: 10.3791/63078.

Animals respond to threatening situations by exhibiting a number of defensive behaviors, including avoidance, freezing, and risk assessment. An animal model with an ethological approach offers a deeper insight into the biological mechanisms underlying threat responses. This paper describes...

Altered Dynamic Information Flow through the Cortico-Basal Ganglia Pathways Mediates Parkinson's Disease Symptoms.

Cerebral cortex (New York, N.Y. : 1991)

Chiken S, Takada M, Nambu A.
PMID: 34268560
Cereb Cortex. 2021 Oct 22;31(12):5363-5380. doi: 10.1093/cercor/bhab164.

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by dopamine deficiency. To elucidate network-level changes through the cortico-basal ganglia pathways in PD, we recorded neuronal activity in PD monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. We applied electrical stimulation to the...

Stimulation of mu opioid, but not GABAergic, receptors of the lateral habenula alters free feeding in rats.

Neuroscience letters

Carlson HN, Christensen BA, Pratt WE.
PMID: 34954115
Neurosci Lett. 2021 Dec 23;771:136417. doi: 10.1016/j.neulet.2021.136417. Epub 2021 Dec 23.

Overconsumption, or eating beyond the point of homeostasis, is a key feature in the development of obesity. Although people are consuming beyond the point of homeostasis, they are not consuming constantly or indefinitely. Thus, there is likely a mechanism...

Bilateral control of interceptive saccades: evidence from the ipsipulsion of vertical saccades after caudal fastigial inactivation.

Journal of neurophysiology

Bourrelly C, Quinet J, Goffart L.
PMID: 33826443
J Neurophysiol. 2021 Jun 01;125(6):2068-2083. doi: 10.1152/jn.00037.2021. Epub 2021 Apr 07.

The caudal fastigial nuclei (cFN) are the output nuclei by which the medio-posterior cerebellum influences the production of saccades toward a visual target. On the basis of the organization of their efferences to the premotor burst neurons and the...

Retinal vessel tortuosity as a prognostic marker for disease severity in Fabry disease.

Orphanet journal of rare diseases

Atiskova Y, Wildner J, Spitzer MS, Aries C, Muschol N, Dulz S.
PMID: 34801073
Orphanet J Rare Dis. 2021 Nov 20;16(1):485. doi: 10.1186/s13023-021-02080-0.

PURPOSE: The aim of this case control study was to evaluate the prognostic value of automatically quantified retinal vessel tortuosity from fundus images and vessel density from OCT-A in Fabry disease and to evaluate the correlation of these with...

Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.

Pain

Loeza-Alcocer E, Gold MS.
PMID: 34726659
Pain. 2021 Nov 01; doi: 10.1097/j.pain.0000000000002526. Epub 2021 Nov 01.

ABSTRACT: Pain is a common and debilitating symptom of inflammatory bowel disease (IBD). Based on evidence that peripheral GABAA receptor (GAR) inhibition plays an important role in establishing colonic afferent excitability and nociceptive threshold, we hypothesized that the increase...

Stimulation of mu opioid, but not GABAergic, receptors of the lateral habenula alters free feeding in rats.

Neuroscience letters

Carlson HN, Christensen BA, Pratt WE.
PMID: 34954115
Neurosci Lett. 2021 Dec 23;771:136417. doi: 10.1016/j.neulet.2021.136417. Epub 2021 Dec 23.

Overconsumption, or eating beyond the point of homeostasis, is a key feature in the development of obesity. Although people are consuming beyond the point of homeostasis, they are not consuming constantly or indefinitely. Thus, there is likely a mechanism...

Thyroid hormones during the perinatal period are necessary to respiratory network development of newborn rats.

Experimental neurology

Rousseau JP, Tenorio-Lopes L, Ghio SC, Desjardins P, Fournier S, Kinkead R.
PMID: 34284029
Exp Neurol. 2021 Nov;345:113813. doi: 10.1016/j.expneurol.2021.113813. Epub 2021 Jul 18.

Thyroid hormones (THs) are essential for foetal brain development. Because the gestating mother is the main source of THs to the foetus, maternal hypothyroidism and/or premature birth compromise neurological outcomes in the offspring. Respiratory instability and recurrent apneas due...

Showing 289 to 297 of 297 entries