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Showing 181 to 188 of 188 entries
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Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer.

Oncogenesis

Sheen MR, Marotti JD, Allegrezza MJ, Rutkowski M, Conejo-Garcia JR, Fiering S.
PMID: 27797363
Oncogenesis. 2016 Oct 31;5(10):e267. doi: 10.1038/oncsis.2016.65.

The gene encoding phosphatidylinositol 3-kinase catalytic subunit α-isoform (PIK3CA, p110α) is frequently activated by mutation in human cancers. Based on detection in some breast cancer precursors, PIK3CA mutations have been proposed to have a role in tumor initiation. To...

Initial experience with a novel EUS-guided core biopsy needle (SharkCore): results of a large North American multicenter study.

Endoscopy international open

DiMaio CJ, Kolb JM, Benias PC, Shah H, Shah S, Haluszka O, Maranki J, Sharzehi K, Lam E, Gordon SR, Hyder SM, Kaimakliotis PZ, Allaparthi SB, Gress FG, Sethi A, Shah AR, Nieto J, Kaul V, Kothari S, Kothari TH, Ho S, Izzy MJ, Sharma NR, Watson RR, Muthusamy VR, Pleskow DK, Berzin TM, Sawhney M, Aljahdi E, Ryou M, Wong CK, Gupta P, Yang D, Gonzalez S, Adler DG.
PMID: 27652304
Endosc Int Open. 2016 Sep;4(9):E974-9. doi: 10.1055/s-0042-112581. Epub 2016 Aug 30.

BACKGROUND AND AIMS: The ability to safely and effectively obtain sufficient tissue for pathologic evaluation by using endoscopic ultrasound (EUS) guidance remains a challenge. Novel designs in EUS needles may provide for improved ability to obtain such core biopsies....

Diabetes Pharmacotherapies and Bladder Cancer: A Medicare Epidemiologic Study.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Mackenzie TA, Zaha R, Smith J, Karagas MR, Morden NE.
PMID: 26894755
Diabetes Ther. 2016 Mar;7(1):61-73. doi: 10.1007/s13300-016-0152-4. Epub 2016 Feb 19.

OBJECTIVE: Patients with type II diabetes have an increased risk of bladder cancer and are commonly treated with thiazolidinediones and angiotensin receptor blockers (ARBs), which have been linked to cancer risk. We explored the relationship between use of one...

Validation of in vivo toenail measurements of manganese and mercury using a portable X-ray fluorescence device.

Journal of exposure science & environmental epidemiology

Specht AJ, Zhang X, Young A, Nguyen VT, Christiani DC, Ceballos DM, Allen JG, Weuve J, Nie LH, Weisskopf MG.
PMID: 34211112
J Expo Sci Environ Epidemiol. 2021 Jul 01; doi: 10.1038/s41370-021-00358-w. Epub 2021 Jul 01.

BACKGROUND AND OBJECTIVE: Toenail metal concentrations can be used as an effective biomarker for exposure to environmental toxicants. Typically toenail clippings are measured ex vivo using inductively coupled plasma mass spectrometry (ICP-MS). X-ray fluorescence (XRF) toenail metal measurements done...

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of .

Proceedings of the National Academy of Sciences of the United States of America

Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefeld AE, Kolling FW, LaCroix IS, Gerber SA, Hogan DA, Kasetty S, Nadell CD, Stanton BA.
PMID: 34260396
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). doi: 10.1073/pnas.2105370118.

No abstract available.

Remission-Stage Ovarian Cancer Cell Vaccine with Cowpea Mosaic Virus Adjuvant Prevents Tumor Growth.

Cancers

Stump CT, Ho G, Mao C, Veliz FA, Beiss V, Fields J, Steinmetz NF, Fiering S.
PMID: 33562450
Cancers (Basel). 2021 Feb 05;13(4). doi: 10.3390/cancers13040627.

Ovarian cancer is the deadliest gynecological malignancy. Though most patients enter remission following initial interventions, relapse is common and often fatal. Accordingly, there is a substantial need for ovarian cancer therapies that prevent relapse. Following remission generated by surgical...

Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases.

The journal of pathology. Clinical research

Nierop PM, Höppener DJ, Buisman FE, van der Stok EP, Galjart B, Balachandran VP, Jarnagin WR, Kingham TP, Shia J, Mauer M, Nordlinger B, Julié C, Groot Koerkamp B, Doukas M, Vermeulen PB, Grünhagen DJ, D'Angelica MI, Verhoef C.
PMID: 34480530
J Pathol Clin Res. 2022 Jan;8(1):48-64. doi: 10.1002/cjp2.235. Epub 2021 Sep 04.

Histopathological growth patterns (HGPs) are a reliable, reproducible, and strong prognostic biomarker that can be assessed on haematoxylin and eosin-stained sections of resected colorectal liver metastases (CRLM). Assessment estimates the relative fraction of the tumour-liver interface for each of...

Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.

Cancer immunology, immunotherapy : CII

Butler SE, Brog RA, Chang CH, Sentman CL, Huang YH, Ackerman ME.
PMID: 34046711
Cancer Immunol Immunother. 2022 Jan;71(1):165-176. doi: 10.1007/s00262-021-02971-y. Epub 2021 May 27.

B7H6, a stress-induced ligand which binds to the NK cell receptor NKp30, has recently emerged as a promising candidate for immunotherapy due to its tumor-specific expression on a broad array of human tumors. NKp30 can function as a chimeric...

Showing 181 to 188 of 188 entries