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Programming a Human Commensal Bacterium, .

Cell systems

Mimee M, Tucker AC, Voigt CA, Lu TK.
PMID: 26918244
Cell Syst. 2015 Jul 29;1(1):62-71. doi: 10.1016/j.cels.2015.06.001.

Engineering commensal organisms for challenging applications, such as modulating the gut ecosystem, is hampered by the lack of genetic parts. Here, we describe promoters, ribosome-binding sites, and inducible systems for use in the commensal bacterium

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Mimee M, Tucker AC, Voigt CA, et al. Programming a Human Commensal Bacterium, . Cell Syst. 2015;1(1):62-71doi: 10.1016/j.cels.2015.06.001.
Mimee, M., Tucker, A. C., Voigt, C. A., & Lu, T. K. (2015). Programming a Human Commensal Bacterium, . Cell systems, 1(1), 62-71. https://doi.org/10.1016/j.cels.2015.06.001
Mimee, Mark, et al. "Programming a Human Commensal Bacterium, ." Cell systems vol. 1,1 (2015): 62-71. doi: https://doi.org/10.1016/j.cels.2015.06.001
Mimee M, Tucker AC, Voigt CA, Lu TK. Programming a Human Commensal Bacterium, . Cell Syst. 2015 Jul 29;1(1):62-71. doi: 10.1016/j.cels.2015.06.001. PMID: 26918244; PMCID: PMC4762051.
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NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.

Cell

Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E.
PMID: 34233163
Cell. 2021 Aug 05;184(16):4268-4283.e20. doi: 10.1016/j.cell.2021.06.022. Epub 2021 Jul 06.

Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mitochondrial redox-regulating enzyme nicotinamide nucleotide transhydrogenase (NNT) resulted in cellular...

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Allouche J, Rachmin I, Adhikari K, et al. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021;184(16):4268-4283.e20doi: 10.1016/j.cell.2021.06.022.
Allouche, J., Rachmin, I., Adhikari, K., Pardo, L. M., Lee, J. H., McConnell, A. M., Kato, S., Fan, S., Kawakami, A., Suita, Y., Wakamatsu, K., Igras, V., Zhang, J., Navarro, P. P., Lugo, C. M., Noonan, H. R., Christie, K. A., Itin, K., Mujahid, N., Lo, J. A., Won, C. H., Evans, C. L., Weng, Q. Y., Wang, H., Osseiran, S., Lovas, A., Németh, I., Cozzio, A., Navarini, A. A., Hsiao, J. J., Nguyen, N., Kemény, L. V., Iliopoulos, O., Berking, C., Ruzicka, T., Gonzalez-José, R., Bortolini, M. C., Canizales-Quinteros, S., Acuna-Alonso, V., Gallo, C., Poletti, G., Bedoya, G., Rothhammer, F., Ito, S., Schiaffino, M. V., Chao, L. H., Kleinstiver, B. P., Tishkoff, S., Zon, L. I., Nijsten, T., Ruiz-Linares, A., Fisher, D. E., & Roider, E. (2021). NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell, 184(16), 4268-4283.e20. https://doi.org/10.1016/j.cell.2021.06.022
Allouche, Jennifer, et al. "NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism." Cell vol. 184,16 (2021): 4268-4283.e20. doi: https://doi.org/10.1016/j.cell.2021.06.022
Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 Aug 05;184(16):4268-4283.e20. doi: 10.1016/j.cell.2021.06.022. Epub 2021 Jul 06. PMID: 34233163; PMCID: PMC8349839.
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Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease.

Genome medicine

Walker RL, Vlamakis H, Lee JWJ, Besse LA, Xanthakis V, Vasan RS, Shaw SY, Xavier RJ.
PMID: 34915914
Genome Med. 2021 Dec 17;13(1):188. doi: 10.1186/s13073-021-01007-5.

BACKGROUND: The human gut harbors trillions of microbes that play dynamic roles in health. While the microbiome contributes to many cardiometabolic traits by modulating host inflammation and metabolism, there is an incomplete understanding regarding the extent that and mechanisms...

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Walker RL, Vlamakis H, Lee JWJ, et al. Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease. Genome Med. 2021;13(1):188doi: 10.1186/s13073-021-01007-5.
Walker, R. L., Vlamakis, H., Lee, J. W. J., Besse, L. A., Xanthakis, V., Vasan, R. S., Shaw, S. Y., & Xavier, R. J. (2021). Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease. Genome medicine, 13(1), 188. https://doi.org/10.1186/s13073-021-01007-5
Walker, Rebecca L, et al. "Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease." Genome medicine vol. 13,1 (2021): 188. doi: https://doi.org/10.1186/s13073-021-01007-5
Walker RL, Vlamakis H, Lee JWJ, Besse LA, Xanthakis V, Vasan RS, Shaw SY, Xavier RJ. Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease. Genome Med. 2021 Dec 17;13(1):188. doi: 10.1186/s13073-021-01007-5. PMID: 34915914; PMCID: PMC8680346.
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Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.

Cell host & microbe

Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN.
PMID: 34297922
Cell Host Microbe. 2021 Aug 11;29(8):1294-1304.e4. doi: 10.1016/j.chom.2021.06.019. Epub 2021 Jul 22.

The intestinal microbiome is a key determinant of responses to biologic therapy in inflammatory bowel disease (IBD). However, diverse therapeutics and variable responses among IBD patients have posed challenges in predicting clinical therapeutic success. In this prospective study, we...

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Lee JWJ, Plichta D, Hogstrom L, et al. Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease. Cell Host Microbe. 2021;29(8):1294-1304.e4doi: 10.1016/j.chom.2021.06.019.
Lee, J. W. J., Plichta, D., Hogstrom, L., Borren, N. Z., Lau, H., Gregory, S. M., Tan, W., Khalili, H., Clish, C., Vlamakis, H., Xavier, R. J., & Ananthakrishnan, A. N. (2021). Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease. Cell host & microbe, 29(8), 1294-1304.e4. https://doi.org/10.1016/j.chom.2021.06.019
Lee, Jonathan Wei Jie, et al. "Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease." Cell host & microbe vol. 29,8 (2021): 1294-1304.e4. doi: https://doi.org/10.1016/j.chom.2021.06.019
Lee JWJ, Plichta D, Hogstrom L, Borren NZ, Lau H, Gregory SM, Tan W, Khalili H, Clish C, Vlamakis H, Xavier RJ, Ananthakrishnan AN. Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease. Cell Host Microbe. 2021 Aug 11;29(8):1294-1304.e4. doi: 10.1016/j.chom.2021.06.019. Epub 2021 Jul 22. PMID: 34297922; PMCID: PMC8366279.
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Showing 61 to 64 of 64 entries