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Showing 781 to 792 of 792 entries
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Deep Learning-Based Artificial Intelligence System for Automatic Assessment of Glomerular Pathological Findings in Lupus Nephritis.

Diagnostics (Basel, Switzerland)

Zheng Z, Zhang X, Ding J, Zhang D, Cui J, Fu X, Han J, Zhu P.
PMID: 34829330
Diagnostics (Basel). 2021 Oct 26;11(11). doi: 10.3390/diagnostics11111983.

Accurate assessment of renal histopathology is crucial for the clinical management of patients with lupus nephritis (LN). However, the current classification system has poor interpathologist agreement. This paper proposes a deep convolutional neural network (CNN)-based system that detects and...

Macro-encapsulation of mesenchymal stem cells in acute and chronic liver injury animal models.

Journal of gastroenterology and hepatology

Kang HT, Jang K, Jun DW, Yoon EL, Lee SM, Saeed WK, Lee JH.
PMID: 33554346
J Gastroenterol Hepatol. 2021 Jul;36(7):1997-2007. doi: 10.1111/jgh.15434. Epub 2021 Feb 18.

BACKGROUND AND AIM: Stem cell treatments using scaffolds for liver disease have been well studied. However, macro-encapsulation of mesenchymal stem cells (MSCs) to minimize or inhibit stem cell homing has not been evaluated. Here, we conducted a proof-of-concept study...

Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ.

Methods in molecular biology (Clifton, N.J.)

Hawkinson TR, Sun RC.
PMID: 34902151
Methods Mol Biol. 2022;2437:215-228. doi: 10.1007/978-1-0716-2030-4_15.

Histopathological detection and quantitation of glycogen in situ are important for the assessment of glycogen storage diseases and different types of cancer. The current standard method for defining the regionality of glycogen rely almost exclusively on Periodic Acid-Schiff (PAS)...

Whipple's disease in renal transplant recipients: Management experience of 7 cases from Pakistan.

Transplant infectious disease : an official journal of the Transplantation Society

Nasim A, Dodani SK, Badlani S, Babar ZU, Shakil S, Mubarak M, Luck N, Aziz T.
PMID: 34837443
Transpl Infect Dis. 2021 Nov 27; doi: 10.1111/tid.13769. Epub 2021 Nov 27.

INTRODUCTION: Whipple's disease (WD) is a rare multi-systemic disorder caused by actinomycetes, Tropheryma Whipplei (T. Whipplei). It presents with weight loss, arthralgia and diarrhea and may involve the heart, lung or central nervous system. The use of immunosuppressive medications...

Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice.

Frontiers in physiology

Kuchibhotla VNS, Starkey MR, Reid AT, Heijink IH, Nawijn MC, Hansbro PM, Knight DA.
PMID: 34385933
Front Physiol. 2021 Jul 27;12:690531. doi: 10.3389/fphys.2021.690531. eCollection 2021.

Excessive mucus production is a major feature of allergic asthma. Disruption of epithelial junctions by allergens such as house dust mite (HDM) results in the activation of β-catenin signaling, which has been reported to stimulate goblet cell differentiation. β-catenin...

Quantitative Analyses of Foot Processes, Mitochondria, and Basement Membranes by Structured Illumination Microscopy Using Elastica-Masson- and Periodic-Acid-Schiff-Stained Kidney Sections.

Kidney international reports

Matsumoto A, Matsui I, Katsuma Y, Yasuda S, Shimada K, Namba-Hamano T, Sakaguchi Y, Kaimori JY, Takabatake Y, Inoue K, Isaka Y.
PMID: 34307987
Kidney Int Rep. 2021 May 01;6(7):1923-1938. doi: 10.1016/j.ekir.2021.04.021. eCollection 2021 Jul.

INTRODUCTION: Foot process effacement and mitochondrial fission associate with kidney disease pathogenesis. Electron microscopy is the gold-standard method for their visualization, but the observable area of electron microscopy is smaller than light microscopy. It is important to develop alternative...

All-trans-retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating autophagy.

American journal of translational research

Fang S, Hu C, Xu L, Cui J, Tao L, Gong M, Wang Y, He Y, He T, Bi Y.
PMID: 33194073
Am J Transl Res. 2020 Oct 15;12(10):6793-6810. eCollection 2020.

Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths due to its high rate of recurrence and metastasis. All-trans-retinoic acid (ATRA) can inhibit the malignant behaviors of hepatocarcinoma cells. Autophagy is reportedly involved in the migration and metastasis...

Onychomycosis and Tinea Pedis in the Feet of Patients With Diabetes.

The international journal of lower extremity wounds

Aragón-Sánchez J, López-Valverde ME, Víquez-Molina G, Milagro-Beamonte A, Torres-Sopena L.
PMID: 33891512
Int J Low Extrem Wounds. 2021 Apr 23;15347346211009409. doi: 10.1177/15347346211009409. Epub 2021 Apr 23.

This study aimed to determine the prevalence of onychomycosis and interdigital tinea pedis in a cohort of Spanish patients with diabetes in whom onychomycosis was clinically suspected (n = 101). Samples from a first toenail scraping and the fourth...

Characteristics of a decellularized human ovarian tissue created by combined protocols and its interaction with human endometrial mesenchymal cells.

Progress in biomaterials

Sistani MN, Zavareh S, Valujerdi MR, Salehnia M.
PMID: 34482521
Prog Biomater. 2021 Sep;10(3):195-206. doi: 10.1007/s40204-021-00163-6. Epub 2021 Sep 05.

The present study makes assessments by analyzing the efficacy of combined decellularization protocol for human ovarian fragments. Tissues were decellularized by freeze-thaw cycles, and treated with Triton X-100 and four concentrations (0.1, 0.5, 1 and 1.5%) of sodium dodecyl...

Characterization of Morphologic and Cytochemical Staining Properties of Exogenous Materials Mimicking Fungal Organisms Encountered in Skin Biopsies.

The American Journal of dermatopathology

Lindsey M, Vishal S, Gardner JM, Shalin SC.
PMID: 34546986
Am J Dermatopathol. 2021 Oct 01;43(10):679-687. doi: 10.1097/DAD.0000000000001854.

BACKGROUND: Exogenous materials may be encountered in skin biopsies as contamination. Contamination may occur during the biopsy procedure in the clinic or during tissue processing in the laboratory. Although the experienced pathologist may often instinctively ignore clear examples of...

Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression.

The ocular surface

Swamynathan S, Campbell G, Tiwari A, Swamynathan SK.
PMID: 34923162
Ocul Surf. 2021 Dec 16;24:1-11. doi: 10.1016/j.jtos.2021.12.006. Epub 2021 Dec 16.

PURPOSE: Previously we demonstrated that the secreted Ly-6/uPAR related protein-1 (SLURP1), abundantly expressed in the corneal epithelium (CE) and secreted into the tear fluid, serves as an anti-inflammatory and anti-angiogenic molecule. Here we describe the Slurp1-null (Slurp1X-/-) mouse corneal...

Prenatal exposure to di(n-butyl) phthalate delays the spermatogenic cycle in rats: Investigation using a BrdU-injection method.

Reproductive toxicology (Elmsford, N.Y.)

Wakui S, Sato D, Okayama Y, Kansaku N, Muto T.
PMID: 35032615
Reprod Toxicol. 2022 Jan 12; doi: 10.1016/j.reprotox.2022.01.003. Epub 2022 Jan 12.

Di(n-butyl) phthalate (DBP) esters are plasticizers that are used to provide transparency and flexibility in household plastic products but can easily leach out to contaminate organisms and the environment. We investigated whether prenatal DBP exposure affects spermatogenesis in rats....

Showing 781 to 792 of 792 entries