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Showing 25 to 36 of 45 entries
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Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src.

Hypertension (Dallas, Tex. : 1979)

Wang Z, Brecher P.
PMID: 11208770
Hypertension. 2001 Jan;37(1):148-153. doi: 10.1161/01.hyp.37.1.148.

-The anti-inflammatory effects of salicylate are well known, but the intracellular mechanisms underlying those effects remain to be clarified and are not explained solely by an influence on cyclooxygenase activity. In the present study, we have used cardiac fibroblasts...

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Wang Z, Brecher P. Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src. Hypertension. 2001;37(1):148-153doi: 10.1161/01.hyp.37.1.148.
Wang, Z., & Brecher, P. (2001). Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src. Hypertension (Dallas, Tex. : 1979), 37(1), 148-153. https://doi.org/10.1161/01.hyp.37.1.148
Wang, Zhongyan, and Brecher, Peter. "Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src." Hypertension (Dallas, Tex. : 1979) vol. 37,1 (2001): 148-153. doi: https://doi.org/10.1161/01.hyp.37.1.148
Wang Z, Brecher P. Salicylate Inhibits Phosphorylation of the Nonreceptor Tyrosine Kinases, Proline-Rich Tyrosine Kinase 2 and c-Src. Hypertension. 2001 Jan;37(1):148-153. doi: 10.1161/01.hyp.37.1.148. PMID: 11208770.
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Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model.

Blood cancer journal

Decaup E, Jean C, Laurent C, Gravelle P, Fruchon S, Capilla F, Marrot A, Al Saati T, Frenois FX, Laurent G, Klein C, Varoqueaux N, Savina A, Fournié JJ, Bezombes C.
PMID: 23933705
Blood Cancer J. 2013 Aug 09;3:e131. doi: 10.1038/bcj.2013.32.

Follicular lymphomas (FLs) account for 35-40% of all adult lymphomas. Treatment typically involves chemotherapy combined with the anti-CD20 monoclonal antibody (MAb) rituximab (RTX). The development of the type II anti-CD20 MAb obinutuzumab (GA101) aims to further improve treatment. Here,...

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Decaup E, Jean C, Laurent C, et al. Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model. Blood Cancer J. 2013;3:e131doi: 10.1038/bcj.2013.32.
Decaup, E., Jean, C., Laurent, C., Gravelle, P., Fruchon, S., Capilla, F., Marrot, A., Al Saati, T., Frenois, F. X., Laurent, G., Klein, C., Varoqueaux, N., Savina, A., Fournié, J. J., & Bezombes, C. (2013). Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model. Blood cancer journal, 3e131. https://doi.org/10.1038/bcj.2013.32
Decaup, E, et al. "Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model." Blood cancer journal vol. 3 (2013): e131. doi: https://doi.org/10.1038/bcj.2013.32
Decaup E, Jean C, Laurent C, Gravelle P, Fruchon S, Capilla F, Marrot A, Al Saati T, Frenois FX, Laurent G, Klein C, Varoqueaux N, Savina A, Fournié JJ, Bezombes C. Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model. Blood Cancer J. 2013 Aug 09;3:e131. doi: 10.1038/bcj.2013.32. PMID: 23933705; PMCID: PMC3763386.
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Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation.

Cancer research and treatment

Shin SY, Lee YH, Baek SH, Kim SY, Kim JR, Kim JH.
PMID: 26680818
Cancer Res Treat. 2001 Oct;33(5):427-32. doi: 10.4143/crt.2001.33.5.427.

PURPOSE: It has been demonstrated that PLC-gamma1 is overexpressed in many tumor cells, and that overexpression of Phospholipase C (PLC)-gamma1 is associated with tumor progression. In order to understand the effect of the PLC-gamma1 overexpression on the regulation of...

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Shin SY, Lee YH, Baek SH, et al. Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation. Cancer Res Treat. 2001;33(5):427-32doi: 10.4143/crt.2001.33.5.427.
Shin, S. Y., Lee, Y. H., Baek, S. H., Kim, S. Y., Kim, J. R., & Kim, J. H. (2001). Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation. Cancer research and treatment, 33(5), 427-32. https://doi.org/10.4143/crt.2001.33.5.427
Shin, S Y, et al. "Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation." Cancer research and treatment vol. 33,5 (2001): 427-32. doi: https://doi.org/10.4143/crt.2001.33.5.427
Shin SY, Lee YH, Baek SH, Kim SY, Kim JR, Kim JH. Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation. Cancer Res Treat. 2001 Oct;33(5):427-32. doi: 10.4143/crt.2001.33.5.427. PMID: 26680818.
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The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces.

Molecular biology of the cell

Wakefield DL, Holowka D, Baird B.
PMID: 28794269
Mol Biol Cell. 2017 Aug 09; doi: 10.1091/mbc.E17-03-0208. Epub 2017 Aug 09.

We examined the spatial targeting of early and downstream signaling mediated by the IgE receptor (FcεRI) in RBL mast cells utilizing surface-patterned 2,4 dinitrophenyl (DNP) ligands. Micron-sized features of DNP are presented as densely immobilized conjugates of bovine serum...

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Wakefield DL, Holowka D, Baird B. The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces. Mol Biol Cell. 2017;doi: 10.1091/mbc.E17-03-0208.
Wakefield, D. L., Holowka, D., & Baird, B. (2017). The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces. Molecular biology of the cell, . https://doi.org/10.1091/mbc.E17-03-0208
Wakefield, Devin L, et al. "The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces." Molecular biology of the cell vol. (2017). doi: https://doi.org/10.1091/mbc.E17-03-0208
Wakefield DL, Holowka D, Baird B. The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces. Mol Biol Cell. 2017 Aug 09; doi: 10.1091/mbc.E17-03-0208. Epub 2017 Aug 09. PMID: 28794269; PMCID: PMC5687038.
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Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering.

Bioengineering & translational medicine

Kim CS, Yang X, Jacobsen S, Masters KS, Kreeger PK.
PMID: 31572796
Bioeng Transl Med. 2019 Jun 26;4(3):e10138. doi: 10.1002/btm2.10138. eCollection 2019 Sep.

Re-epithelialization is a critical step in wound healing and results from the collective migration of keratinocytes. Previous work demonstrated that immobilized, but not soluble, epidermal growth factor (EGF) resulted in leader cell-specific activation of phospholipase C gamma 1 (PLCγ1)...

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Kim CS, Yang X, Jacobsen S, et al. Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering. Bioeng Transl Med. 2019;4(3):e10138doi: 10.1002/btm2.10138.
Kim, C. S., Yang, X., Jacobsen, S., Masters, K. S., & Kreeger, P. K. (2019). Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering. Bioengineering & translational medicine, 4(3), e10138. https://doi.org/10.1002/btm2.10138
Kim, Chloe S, et al. "Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering." Bioengineering & translational medicine vol. 4,3 (2019): e10138. doi: https://doi.org/10.1002/btm2.10138
Kim CS, Yang X, Jacobsen S, Masters KS, Kreeger PK. Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering. Bioeng Transl Med. 2019 Jun 26;4(3):e10138. doi: 10.1002/btm2.10138. eCollection 2019 Sep. PMID: 31572796; PMCID: PMC6764804.
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Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; .

Clinical case reports

Kutukculer N, Topyildiz E, Berdeli A, Guven Bilgin B, Aykut A, Durmaz A, Cogulu O, Aksu G, Edeer Karaca N.
PMID: 33936634
Clin Case Rep. 2021 Mar 02;9(4):2023-2031. doi: 10.1002/ccr3.3934. eCollection 2021 Apr.

We suggest PLAID, APLAID, and FCAS3 have to be considered as different aspects of the same underlying condition, because of our long-term clinical and genetical experiences. Some CVID patients have the same disease-causing mutations in

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Kutukculer N, Topyildiz E, Berdeli A, et al. Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; . Clin Case Rep. 2021;9(4):2023-2031doi: 10.1002/ccr3.3934.
Kutukculer, N., Topyildiz, E., Berdeli, A., Guven Bilgin, B., Aykut, A., Durmaz, A., Cogulu, O., Aksu, G., & Edeer Karaca, N. (2021). Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; . Clinical case reports, 9(4), 2023-2031. https://doi.org/10.1002/ccr3.3934
Kutukculer, Necil, et al. "Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; ." Clinical case reports vol. 9,4 (2021): 2023-2031. doi: https://doi.org/10.1002/ccr3.3934
Kutukculer N, Topyildiz E, Berdeli A, Guven Bilgin B, Aykut A, Durmaz A, Cogulu O, Aksu G, Edeer Karaca N. Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; . Clin Case Rep. 2021 Mar 02;9(4):2023-2031. doi: 10.1002/ccr3.3934. eCollection 2021 Apr. PMID: 33936634; PMCID: PMC8077279.
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Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML.

Oncotarget

Mahmud H, Scherpen FJG, de Boer TM, Lourens HJ, Schoenherr C, Eder M, Scherr M, Guryev V, De Bont ES.
PMID: 28978037
Oncotarget. 2017 Jun 27;8(40):67344-67354. doi: 10.18632/oncotarget.18631. eCollection 2017 Sep 15.

The t(8;21) (q22;q22) chromosomal translocation is one of the most frequent genetic alterations in acute myeloid leukemia (AML) which has a need for improved therapeutic strategies. We found PLC-γ1 as one of the highest phosphorylated peptides in t(8;21) AML...

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Mahmud H, Scherpen FJG, de Boer TM, et al. Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML. Oncotarget. 2017;8(40):67344-67354doi: 10.18632/oncotarget.18631.
Mahmud, H., Scherpen, F. J. G., de Boer, T. M., Lourens, H. J., Schoenherr, C., Eder, M., Scherr, M., Guryev, V., & De Bont, E. S. (2017). Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML. Oncotarget, 8(40), 67344-67354. https://doi.org/10.18632/oncotarget.18631
Mahmud, Hasan, et al. "Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML." Oncotarget vol. 8,40 (2017): 67344-67354. doi: https://doi.org/10.18632/oncotarget.18631
Mahmud H, Scherpen FJG, de Boer TM, Lourens HJ, Schoenherr C, Eder M, Scherr M, Guryev V, De Bont ES. Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML. Oncotarget. 2017 Jun 27;8(40):67344-67354. doi: 10.18632/oncotarget.18631. eCollection 2017 Sep 15. PMID: 28978037; PMCID: PMC5620177.
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Activated HGF-c-Met Axis in Head and Neck Cancer.

Cancers

Arnold L, Enders J, Thomas SM.
PMID: 29231907
Cancers (Basel). 2017 Dec 12;9(12). doi: 10.3390/cancers9120169.

Head and neck squamous cell carcinoma (HNSCC) is a highly morbid disease. Recent developments including Food and Drug Administration (FDA) approved molecular targeted agent's pembrolizumab and cetuximab show promise but did not improve the five-year survival which is currently...

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Arnold L, Enders J, Thomas SM. Activated HGF-c-Met Axis in Head and Neck Cancer. Cancers (Basel). 2017;9(12)doi: 10.3390/cancers9120169.
Arnold, L., Enders, J., & Thomas, S. M. (2017). Activated HGF-c-Met Axis in Head and Neck Cancer. Cancers, 9(12), . https://doi.org/10.3390/cancers9120169
Arnold, Levi, et al. "Activated HGF-c-Met Axis in Head and Neck Cancer." Cancers vol. 9,12 (2017). doi: https://doi.org/10.3390/cancers9120169
Arnold L, Enders J, Thomas SM. Activated HGF-c-Met Axis in Head and Neck Cancer. Cancers (Basel). 2017 Dec 12;9(12). doi: 10.3390/cancers9120169. PMID: 29231907; PMCID: PMC5742817.
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Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology

Tang W, Zhou Y, Sun D, Dong L, Xia J, Yang B.
PMID: 30623526
Hepatol Res. 2019 May;49(5):559-569. doi: 10.1111/hepr.13309. Epub 2019 Feb 20.

AIM: Phospholipase C-γ1 (PLCG1) was previously found to be involved in a variety of oncogenic behaviors such as cell motility, cell proliferation, cell migration, and invasion. However, its function in hepatocellular carcinoma (HCC) was unknown. Here, we explored the...

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Tang W, Zhou Y, Sun D, et al. Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma. Hepatol Res. 2019;49(5):559-569doi: 10.1111/hepr.13309.
Tang, W., Zhou, Y., Sun, D., Dong, L., Xia, J., & Yang, B. (2019). Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma. Hepatology research : the official journal of the Japan Society of Hepatology, 49(5), 559-569. https://doi.org/10.1111/hepr.13309
Tang, Wenqing, et al. "Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma." Hepatology research : the official journal of the Japan Society of Hepatology vol. 49,5 (2019): 559-569. doi: https://doi.org/10.1111/hepr.13309
Tang W, Zhou Y, Sun D, Dong L, Xia J, Yang B. Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma. Hepatol Res. 2019 May;49(5):559-569. doi: 10.1111/hepr.13309. Epub 2019 Feb 20. PMID: 30623526.
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Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.

Proceedings of the National Academy of Sciences of the United States of America

[No authors listed]
PMID: 33579793
Proc Natl Acad Sci U S A. 2021 Mar 02;118(9). doi: 10.1073/pnas.2101727118.

No abstract available.

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Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening. Proc Natl Acad Sci U S A. 2021;118(9)doi: 10.1073/pnas.2101727118.
(2021). Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening. Proceedings of the National Academy of Sciences of the United States of America, 118(9), . https://doi.org/10.1073/pnas.2101727118
"Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening." Proceedings of the National Academy of Sciences of the United States of America vol. 118,9 (2021). doi: https://doi.org/10.1073/pnas.2101727118
Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening. Proc Natl Acad Sci U S A. 2021 Mar 02;118(9). doi: 10.1073/pnas.2101727118. PMID: 33579793; PMCID: PMC7936327.
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Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer.

Frontiers in genetics

Wang F, Meng F, Wang L, Wong SC, Cho WC, Chan LW.
PMID: 27790245
Front Genet. 2016 Oct 13;7:173. doi: 10.3389/fgene.2016.00173. eCollection 2016.

Lung cancer is the top cancer killer worldwide with high mortality rate. Majority belong to non-small cell lung cancers (NSCLCs). The epidermal growth factor receptor (EGFR) has been broadly explored as a drug target for therapy. However, the drug...

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Wang F, Meng F, Wang L, et al. Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer. Front Genet. 2016;7:173doi: 10.3389/fgene.2016.00173.
Wang, F., Meng, F., Wang, L., Wong, S. C., Cho, W. C., & Chan, L. W. (2016). Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer. Frontiers in genetics, 7173. https://doi.org/10.3389/fgene.2016.00173
Wang, Fengfeng, et al. "Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer." Frontiers in genetics vol. 7 (2016): 173. doi: https://doi.org/10.3389/fgene.2016.00173
Wang F, Meng F, Wang L, Wong SC, Cho WC, Chan LW. Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer. Front Genet. 2016 Oct 13;7:173. doi: 10.3389/fgene.2016.00173. eCollection 2016. PMID: 27790245; PMCID: PMC5061729.
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Effects of tributyltin on protein tyrosine kinases and phospholipase C gamma in human natural killer cells.

Toxicology mechanisms and methods

Odman-Ghazi SO, Person RJ, Whalen MM.
PMID: 20020888
Toxicol Mech Methods. 2008;18(1):25-33. doi: 10.1080/15376510701703920.

ABSTRACT Tributyltin (TBT) has been used in wood preservation, marine antifouling paints, disinfection of circulating industrial cooling waters, and slime control in paper mills. Detectable levels have been found in human blood. Exposure to TBT decreases the tumor cell...

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Odman-Ghazi SO, Person RJ, Whalen MM. Effects of tributyltin on protein tyrosine kinases and phospholipase C gamma in human natural killer cells. Toxicol Mech Methods. 2008;18(1):25-33doi: 10.1080/15376510701703920.
Odman-Ghazi, S. O., Person, R. J., & Whalen, M. M. (2008). Effects of tributyltin on protein tyrosine kinases and phospholipase C gamma in human natural killer cells. Toxicology mechanisms and methods, 18(1), 25-33. https://doi.org/10.1080/15376510701703920
Odman-Ghazi, Sabah O, et al. "Effects of tributyltin on protein tyrosine kinases and phospholipase C gamma in human natural killer cells." Toxicology mechanisms and methods vol. 18,1 (2008): 25-33. doi: https://doi.org/10.1080/15376510701703920
Odman-Ghazi SO, Person RJ, Whalen MM. Effects of tributyltin on protein tyrosine kinases and phospholipase C gamma in human natural killer cells. Toxicol Mech Methods. 2008;18(1):25-33. doi: 10.1080/15376510701703920. PMID: 20020888.
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Showing 25 to 36 of 45 entries