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Showing 37 to 45 of 45 entries
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Corticotropin-releasing hormone-binding protein is up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons.

Journal of neurochemistry

Adachi N, Suzuki S, Matsuoka H, Fushimi S, Ono J, Ohta KI, Hirai Y, Miki T, Koshimizu H.
PMID: 29355947
J Neurochem. 2018 Jan 22; doi: 10.1111/jnc.14310. Epub 2018 Jan 22.

A recent study revealed that corticotropin-releasing hormone (CRH) in the cerebral cortex (CTX) plays a regulatory role in emotional behaviors in rodents. Given the functional interaction between brain-derived neurotrophic factor (BDNF) and the CRH-signaling pathway in the hypothalamic-pituitary-adrenal axis,...

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Adachi N, Suzuki S, Matsuoka H, et al. Corticotropin-releasing hormone-binding protein is up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons. J Neurochem. 2018;doi: 10.1111/jnc.14310.
Adachi, N., Suzuki, S., Matsuoka, H., Fushimi, S., Ono, J., Ohta, K. I., Hirai, Y., Miki, T., & Koshimizu, H. (2018). Corticotropin-releasing hormone-binding protein is up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons. Journal of neurochemistry, . https://doi.org/10.1111/jnc.14310
Adachi, Naoki, et al. "Corticotropin-releasing hormone-binding protein is up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons." Journal of neurochemistry vol. (2018). doi: https://doi.org/10.1111/jnc.14310
Adachi N, Suzuki S, Matsuoka H, Fushimi S, Ono J, Ohta KI, Hirai Y, Miki T, Koshimizu H. Corticotropin-releasing hormone-binding protein is up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons. J Neurochem. 2018 Jan 22; doi: 10.1111/jnc.14310. Epub 2018 Jan 22. PMID: 29355947.
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TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.

Molecular neurodegeneration

Magno L, Bunney TD, Mead E, Svensson F, Bictash MN.
PMID: 33823896
Mol Neurodegener. 2021 Apr 06;16(1):22. doi: 10.1186/s13024-021-00436-5.

The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However,...

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Magno L, Bunney TD, Mead E, et al. TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation. Mol Neurodegener. 2021;16(1):22doi: 10.1186/s13024-021-00436-5.
Magno, L., Bunney, T. D., Mead, E., Svensson, F., & Bictash, M. N. (2021). TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation. Molecular neurodegeneration, 16(1), 22. https://doi.org/10.1186/s13024-021-00436-5
Magno, Lorenza, et al. "TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation." Molecular neurodegeneration vol. 16,1 (2021): 22. doi: https://doi.org/10.1186/s13024-021-00436-5
Magno L, Bunney TD, Mead E, Svensson F, Bictash MN. TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation. Mol Neurodegener. 2021 Apr 06;16(1):22. doi: 10.1186/s13024-021-00436-5. PMID: 33823896; PMCID: PMC8022522.
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The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance.

Journal of molecular biology

Joseph RE, Lowe J, Fulton DB, Engen JR, Wales TE, Andreotti AH.
PMID: 34954235
J Mol Biol. 2021 Dec 23;434(5):167422. doi: 10.1016/j.jmb.2021.167422. Epub 2021 Dec 23.

Mutations in PLCγ, a substrate of the tyrosine kinase BTK, are often found in patients who develop resistance to the BTK inhibitor Ibrutinib. However, the mechanisms by which these PLCγ mutations cause Ibrutinib resistance are unclear. Under normal signaling...

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Joseph RE, Lowe J, Fulton DB, et al. The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. J Mol Biol. 2021;434(5):167422doi: 10.1016/j.jmb.2021.167422.
Joseph, R. E., Lowe, J., Fulton, D. B., Engen, J. R., Wales, T. E., & Andreotti, A. H. (2021). The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. Journal of molecular biology, 434(5), 167422. https://doi.org/10.1016/j.jmb.2021.167422
Joseph, Raji E, et al. "The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance." Journal of molecular biology vol. 434,5 (2021): 167422. doi: https://doi.org/10.1016/j.jmb.2021.167422
Joseph RE, Lowe J, Fulton DB, Engen JR, Wales TE, Andreotti AH. The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. J Mol Biol. 2021 Dec 23;434(5):167422. doi: 10.1016/j.jmb.2021.167422. Epub 2021 Dec 23. PMID: 34954235.
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Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells.

Animal biotechnology

Zheng J, Liu G, Wu C, Jia G, Zhao H, Chen X, Wang J.
PMID: 34459707
Anim Biotechnol. 2021 Aug 30;1-10. doi: 10.1080/10495398.2021.1968885. Epub 2021 Aug 30.

The rapid healing of impaired intestinal surface plays a role in maintaining intestinal homeostasis. This study investigated the effect of calcium-sensing receptor (CaSR) on the migration and proliferation of intestinal porcine epithelial cells (IPEC-J2). Results showed that cell migration...

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Zheng J, Liu G, Wu C, et al. Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells. Anim Biotechnol. 2021;1-10doi: 10.1080/10495398.2021.1968885.
Zheng, J., Liu, G., Wu, C., Jia, G., Zhao, H., Chen, X., & Wang, J. (2021). Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells. Animal biotechnology, 1-10. https://doi.org/10.1080/10495398.2021.1968885
Zheng, Jie, et al. "Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells." Animal biotechnology vol. (2021): 1-10. doi: https://doi.org/10.1080/10495398.2021.1968885
Zheng J, Liu G, Wu C, Jia G, Zhao H, Chen X, Wang J. Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells. Anim Biotechnol. 2021 Aug 30;1-10. doi: 10.1080/10495398.2021.1968885. Epub 2021 Aug 30. PMID: 34459707.
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A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia.

European journal of medical genetics

Park HS, Oh A, Keum CW, Lee J, Lee JK, Son BR, Shin KS, Hahn YS.
PMID: 34768012
Eur J Med Genet. 2022 Jan;65(1):104387. doi: 10.1016/j.ejmg.2021.104387. Epub 2021 Nov 09.

Pathogenic variants of PLCG2 encoding phospholipase C gamma 2 (PLCγ2) were first reported in 2012 and their clinical manifestations vary widely. PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammation and PLCγ2-associated antibody deficiency and immune dysregulation (APLAID) are...

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Park HS, Oh A, Keum CW, et al. A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia. Eur J Med Genet. 2021;65(1):104387doi: 10.1016/j.ejmg.2021.104387.
Park, H. S., Oh, A., Keum, C. W., Lee, J., Lee, J. K., Son, B. R., Shin, K. S., & Hahn, Y. S. (2022). A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia. European journal of medical genetics, 65(1), 104387. https://doi.org/10.1016/j.ejmg.2021.104387
Park, Hee Sue, et al. "A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia." European journal of medical genetics vol. 65,1 (2022): 104387. doi: https://doi.org/10.1016/j.ejmg.2021.104387
Park HS, Oh A, Keum CW, Lee J, Lee JK, Son BR, Shin KS, Hahn YS. A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia. Eur J Med Genet. 2022 Jan;65(1):104387. doi: 10.1016/j.ejmg.2021.104387. Epub 2021 Nov 09. PMID: 34768012.
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Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Tsai AP, Lin PB, Dong C, Moutinho M, Liu Y, Bissel SJ, Oblak AL, Nho K, Lamb BT, Landreth GE.
PMID: 34971198
Alzheimers Dement. 2021 Dec;17:e058740. doi: 10.1002/alz.058740.

BACKGROUND: Alzheimer's disease (AD) and other neurodegenerative diseases are typified by a robust microglial-mediated immune response. Genetic studies have demonstrated that variants in microglial genes are linked to risk for AD. Phospholipase C gamma 2 (PLCG2), whose variants confer...

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Tsai AP, Lin PB, Dong C, et al. Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease. Alzheimers Dement. 2021;17:e058740doi: 10.1002/alz.058740.
Tsai, A. P., Lin, P. B., Dong, C., Moutinho, M., Liu, Y., Bissel, S. J., Oblak, A. L., Nho, K., Lamb, B. T., & Landreth, G. E. (2021). Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17e058740. https://doi.org/10.1002/alz.058740
Tsai, Andy Po-Yi, et al. "Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17 (2021): e058740. doi: https://doi.org/10.1002/alz.058740
Tsai AP, Lin PB, Dong C, Moutinho M, Liu Y, Bissel SJ, Oblak AL, Nho K, Lamb BT, Landreth GE. Impact of PLCG2 expression on Microglial Biology and Disease Pathogenesis in Alzheimer's Disease. Alzheimers Dement. 2021 Dec;17:e058740. doi: 10.1002/alz.058740. PMID: 34971198.
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The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance.

Journal of molecular biology

Joseph RE, Lowe J, Bruce Fulton D, Engen JR, Wales TE, Andreotti AH.
PMID: 34954235
J Mol Biol. 2021 Dec 23;167422. doi: 10.1016/j.jmb.2021.167422. Epub 2021 Dec 23.

Mutations in PLCγ, a substrate of the tyrosine kinase BTK, are often found in patients who develop resistance to the BTK inhibitor Ibrutinib. However, the mechanisms by which these PLCγ mutations cause Ibrutinib resistance are unclear. Under normal signaling...

Cite
Joseph RE, Lowe J, Bruce Fulton D, et al. The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance. J Mol Biol. 2021;167422doi: 10.1016/j.jmb.2021.167422.
Joseph, R. E., Lowe, J., Bruce Fulton, D., Engen, J. R., Wales, T. E., & Andreotti, A. H. (2021). The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance. Journal of molecular biology, 167422. https://doi.org/10.1016/j.jmb.2021.167422
Joseph, Raji E, et al. "The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance." Journal of molecular biology vol. (2021): 167422. doi: https://doi.org/10.1016/j.jmb.2021.167422
Joseph RE, Lowe J, Bruce Fulton D, Engen JR, Wales TE, Andreotti AH. The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance. J Mol Biol. 2021 Dec 23;167422. doi: 10.1016/j.jmb.2021.167422. Epub 2021 Dec 23. PMID: 34954235.
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Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hu N, Wang F, Sun T, Xu Z, Zhang J, Bernard D, Xu S, Wang S, Kaminski M, Devata S, Phillips T, Malek SN.
PMID: 33419778
Clin Cancer Res. 2021 Apr 15;27(8):2301-2313. doi: 10.1158/1078-0432.CCR-20-3741. Epub 2021 Jan 08.

PURPOSE: On the basis of the recent discovery of mutations in Bruton tyrosine kinase (EXPERIMENTAL DESIGN: We identified novel somatic RESULTS: We uncovered that all BTK mutants destabilized the BTK protein and some created BTK kinase-dead mutants. The phospholipase...

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Hu N, Wang F, Sun T, et al. Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation. Clin Cancer Res. 2021;27(8):2301-2313doi: 10.1158/1078-0432.CCR-20-3741.
Hu, N., Wang, F., Sun, T., Xu, Z., Zhang, J., Bernard, D., Xu, S., Wang, S., Kaminski, M., Devata, S., Phillips, T., & Malek, S. N. (2021). Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(8), 2301-2313. https://doi.org/10.1158/1078-0432.CCR-20-3741
Hu, Nan, et al. "Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,8 (2021): 2301-2313. doi: https://doi.org/10.1158/1078-0432.CCR-20-3741
Hu N, Wang F, Sun T, Xu Z, Zhang J, Bernard D, Xu S, Wang S, Kaminski M, Devata S, Phillips T, Malek SN. Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation. Clin Cancer Res. 2021 Apr 15;27(8):2301-2313. doi: 10.1158/1078-0432.CCR-20-3741. Epub 2021 Jan 08. PMID: 33419778; PMCID: PMC8046715.
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A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia.

European journal of medical genetics

Park HS, Oh A, Keum CW, Lee J, Lee JK, Son BR, Shin KS, Hahn YS.
PMID: 34768012
Eur J Med Genet. 2021 Nov 09;65(1):104387. doi: 10.1016/j.ejmg.2021.104387. Epub 2021 Nov 09.

Pathogenic variants of PLCG2 encoding phospholipase C gamma 2 (PLCγ2) were first reported in 2012 and their clinical manifestations vary widely. PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammation and PLCγ2-associated antibody deficiency and immune dysregulation (APLAID) are...

Cite
Park HS, Oh A, Keum CW, et al. A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia. Eur J Med Genet. 2021;65(1):104387doi: 10.1016/j.ejmg.2021.104387.
Park, H. S., Oh, A., Keum, C. W., Lee, J., Lee, J. K., Son, B. R., Shin, K. S., & Hahn, Y. S. (2021). A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia. European journal of medical genetics, 65(1), 104387. https://doi.org/10.1016/j.ejmg.2021.104387
Park, Hee Sue, et al. "A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia." European journal of medical genetics vol. 65,1 (2021): 104387. doi: https://doi.org/10.1016/j.ejmg.2021.104387
Park HS, Oh A, Keum CW, Lee J, Lee JK, Son BR, Shin KS, Hahn YS. A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia. Eur J Med Genet. 2021 Nov 09;65(1):104387. doi: 10.1016/j.ejmg.2021.104387. Epub 2021 Nov 09. PMID: 34768012.
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Showing 37 to 45 of 45 entries