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Showing 289 to 293 of 293 entries
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Integrated Proteome and Phosphoproteome Analyses Reveal Early- and Late-Stage Protein Networks of Traumatic Brain Injury.

Journal of molecular neuroscience : MN

Huang Y, Zhang H, Yang E, Yue K, Gao X, Dai S, Wei J, Yang Y, Luo P, Li X, Jiang X.
PMID: 35023002
J Mol Neurosci. 2022 Jan 12; doi: 10.1007/s12031-021-01949-w. Epub 2022 Jan 12.

Traumatic brain injury (TBI) is a major public health concern all around the world. Accumulating evidence suggests that pathological processes after brain injury continuously evolve. Here, we identified the differentially expressed proteins (DEPs) and differentially expressed phosphoproteins (DEPPs) in...

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.

Cellular signalling

Sergienko NM, Donner DG, Delbridge LMD, McMullen JR, Weeks KL.
PMID: 34902541
Cell Signal. 2021 Dec 10;91:110213. doi: 10.1016/j.cellsig.2021.110213. Epub 2021 Dec 10.

Protein phosphatases have emerged as critical regulators of phosphoprotein homeostasis in settings of health and disease. Protein phosphatase 2A (PP2A) encompasses a large subfamily of enzymes that remove phosphate groups from serine/threonine residues within phosphoproteins. The heterogeneity in PP2A...

Phosphoproteomics of cold stress-responsive mechanisms in Rhododendron chrysanthum.

Molecular biology reports

Liu Y, Fan H, Dong J, Chen J, Xu H, Zhou X.
PMID: 34743272
Mol Biol Rep. 2022 Jan;49(1):303-312. doi: 10.1007/s11033-021-06874-0. Epub 2021 Nov 06.

BACKGROUND: As an alpine plant, Rhododendron chrysanthum (R. chrysanthum) has evolved cold resistance mechanisms and become a valuable plant resource with the responsive mechanism of cold stress.METHODS AND RESULTS: We adopt the phosphoproteomic and proteomic analysis combining with physiological...

Differential phosphoprotein signaling in the cortex in mouse models of Gulf War Illness using corticosterone and acetylcholinesterase inhibitors.

Heliyon

Penatzer JA, Miller JV, Prince N, Shaw M, Lynch C, Newman M, Hobbs GR, Boyd JW.
PMID: 34307952
Heliyon. 2021 Jul 12;7(7):e07552. doi: 10.1016/j.heliyon.2021.e07552. eCollection 2021 Jul.

AIMS: Veterans from the 1990-91 Gulf War were exposed to acetylcholinesterase inhibitors (AChEIs), and, following service, an estimated one-third began suffering from a medically unexplained, multi-symptom illness termed Gulf War Illness (GWI). Previous research has developed validated rodent models...

Multi-Omics Analysis to Characterize Cigarette Smoke Induced Molecular Alterations in Esophageal Cells.

Frontiers in oncology

Khan AA, Patel K, Patil S, Babu N, Mangalaparthi KK, Solanki HS, Nanjappa V, Kumari A, Manoharan M, Karunakaran C, Murugan S, Nair B, Kumar RV, Biswas M, Sidransky D, Gupta R, Gupta R, Khanna-Gupta A, Kumar P, Chatterjee A, Gowda H.
PMID: 33251127
Front Oncol. 2020 Nov 05;10:1666. doi: 10.3389/fonc.2020.01666. eCollection 2020.

Though smoking remains one of the established risk factors of esophageal squamous cell carcinoma, there is limited data on molecular alterations associated with cigarette smoke exposure in esophageal cells. To investigate molecular alterations associated with chronic exposure to cigarette...

Showing 289 to 293 of 293 entries