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Showing 13 to 24 of 136 entries
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Suppression of sustained and transient ON signals of amacrine cells by GABA is mediated by different receptor subtypes.

Science in China. Series C, Life sciences

Zhang D, Yang R, Yang X.
PMID: 18763130
Sci China C Life Sci. 1999 Aug;42(4):395-400. doi: 10.1007/BF02882059.

Intracellular recordings were made from amacrine cells in the isolated, superfused carp retina, and the effects of gamma-aminobutyric acid (GABA) on sustained and transient ON signals of these cells were studied. Exogenous GABA application partially suppressed the sustained response...

Inhibition by sodium bromide of acetylcholine release and synaptic transmission in the superior cervical ganglion of the rat.

Neurochemistry international

Kása P, Toldi J, Farkas Z, Joó F, Wolff JR.
PMID: 20501192
Neurochem Int. 1987;11(4):443-9. doi: 10.1016/0197-0186(87)90034-9.

In the superior cervical ganglion (SCG) of rats, the interaction of sodium bromide (NaBr) with various drugs which interfere with the GABA system, such as 3-(4-chlorophenyl)-4-aminobutyrate [( + )baclofen, Bac], ( + )bicuculline (Bic), picrotoxin (Pic) and chlorpromazine (CPZ),...

Anterior Cingulate epilepsy: mechanisms and modulation.

Frontiers in integrative neuroscience

Chang WP, Shyu BC.
PMID: 24427123
Front Integr Neurosci. 2014 Jan 03;7:104. doi: 10.3389/fnint.2013.00104.

Epilepsy is a common neurological disorder, about 1% population worldwide suffered from this disease. In 1989, the International League Against Epilepsy (ILAE) classified anterior cingulate epilepsy as a form of frontal lobe epilepsy (FLE). FLE is the second most...

Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors.

International journal of health sciences

Raza M, Alghasham AA, Alorainy MS, El-Hadiyah TM.
PMID: 21475467
Int J Health Sci (Qassim). 2008 Jan;2(1):15-25.

This study investigated antiepileptic effects of the main constituents of Nigella sativa (NS) seed (i.e. aqueous extract (AE), fixed oil (FO), volatile oil (VO)) and the main components of its VO (i.e. thymoquinone, α-pinene and p-cymene) using pentylenetetrazole (PTZ)...

GABAA Receptor- and Non-NMDA Glutamate Receptor-Mediated Actions of Korean Red Ginseng Extract on the Gonadotropin Releasing Hormone Neurons.

Journal of ginseng research

Cho DH, Bhattarai JP, Han SK.
PMID: 23717103
J Ginseng Res. 2012 Jan;36(1):47-54. doi: 10.5142/jgr.2012.36.1.47.

Korean red ginseng (KRG) has been used worldwide as a traditional medicine for the treatment of various reproductive diseases. Gonadotropin releasing hormone (GnRH) neurons are the fundamental regulators of pulsatile release of gonadotropin required for fertility. In this study,...

Effect of Eclipta alba on Acute Seizure Models: a GABAA-mediated Effect.

Indian journal of pharmaceutical sciences

Shaikh MF, Sancheti J, Sathaye S.
PMID: 24082359
Indian J Pharm Sci. 2013 May;75(3):380-4. doi: 10.4103/0250-474X.117432.

In the present study, anticonvulsant activity of methanol extract of Eclipta alba (10-200 mg/kg) was studied using pentylenetetrazole- and picrotoxin-induced seizure models. Mechanism of effect of methanol extract of Eclipta alba was further elucidated by studying its GABAA receptor...

Neurosteroids and GABA-A Receptor Function.

Frontiers in endocrinology

Wang M.
PMID: 22654809
Front Endocrinol (Lausanne). 2011 Oct 04;2:44. doi: 10.3389/fendo.2011.00044. eCollection 2011.

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor. 3α-hydroxy A-ring reduced metabolites of progesterone, deoxycorticosterone, and testosterone are positive modulators...

Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress.

Journal of psychopharmacology (Oxford, England)

Papp M, Lappas S, Muscat R, Willner P.
PMID: 22291379
J Psychopharmacol. 1992 Jan;6(3):352-6. doi: 10.1177/026988119200600302.

Chronic exposure to very mild unpredictable stress has previously been found to reduce or abolish the acquisition of place preference conditioning. In the present study, chronic mild stress was found to abolish the acquisition of preferences for a distinctive...

Effect of acute fentanyl treatment on synaptic plasticity in the hippocampal CA1 region in rats.

Frontiers in pharmacology

Tian H, Xu Y, Liu F, Wang G, Hu S.
PMID: 26578961
Front Pharmacol. 2015 Oct 30;6:251. doi: 10.3389/fphar.2015.00251. eCollection 2015.

Postoperative cognitive dysfunction (POCD), mainly characterized by short-term decline of learning and memory, occurs after operations under anesthesia. However, the underlying mechanisms are poorly understood. The μ-opioid receptors (MOR) are highly expressed in interneurons of hippocampus, and is believed...

Characterization of the Zebrafish Glycine Receptor Family Reveals Insights Into Glycine Receptor Structure Function and Stoichiometry.

Frontiers in molecular neuroscience

Low SE, Ito D, Hirata H.
PMID: 30323738
Front Mol Neurosci. 2018 Sep 03;11:286. doi: 10.3389/fnmol.2018.00286. eCollection 2018.

To study characterization of zebrafish glycine receptors (zGlyRs), we assessed expression and function of five α- and two ß-subunit encoding GlyR in zebrafish. Our qPCR analysis revealed variable expression during development, while

Physiological Action of Picrotoxin.

Glasgow medical journal

Roeber H.
PMID: 30432676
Glasgow Med J. 1869 May;1(3):361-368.

No abstract available.

Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABA.

Frontiers in synaptic neuroscience

Shu HJ, Lu X, Bracamontes J, Steinbach JH, Zorumski CF, Mennerick S.
PMID: 34867260
Front Synaptic Neurosci. 2021 Nov 18;13:763411. doi: 10.3389/fnsyn.2021.763411. eCollection 2021.

GABA

Showing 13 to 24 of 136 entries