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Showing 13 to 24 of 213 entries
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Voltage-gated calcium channels contribute to spontaneous glutamate release directly via nanodomain coupling or indirectly via calmodulin.

Progress in neurobiology

Lee BJ, Yang CH, Lee SY, Lee SH, Kim Y, Ho WK.
PMID: 34695543
Prog Neurobiol. 2022 Jan;208:102182. doi: 10.1016/j.pneurobio.2021.102182. Epub 2021 Oct 22.

Neurotransmitter release occurs either synchronously with action potentials (evoked release) or spontaneously (spontaneous release). Whether the molecular mechanisms underlying evoked and spontaneous release are identical, especially whether voltage-gated calcium channels (VGCCs) can trigger spontaneous events, is still a matter...

Toward personalized medicine in connectomic deep brain stimulation.

Progress in neurobiology

Hollunder B, Rajamani N, Siddiqi SH, Finke C, Kühn AA, Mayberg HS, Fox MD, Neudorfer C, Horn A.
PMID: 34958874
Prog Neurobiol. 2021 Dec 24;102211. doi: 10.1016/j.pneurobio.2021.102211. Epub 2021 Dec 24.

At the group-level, deep brain stimulation leads to significant therapeutic benefit in a multitude of neurological and neuropsychiatric disorders. At the single-patient level, however, symptoms may sometimes persist despite "optimal" electrode placement at established treatment coordinates. This may be...

A common role for astrocytes in rhythmic behaviours?.

Progress in neurobiology

Broadhead MJ, Miles GB.
PMID: 33894330
Prog Neurobiol. 2021 Jul;202:102052. doi: 10.1016/j.pneurobio.2021.102052. Epub 2021 Apr 21.

Astrocytes are a functionally diverse form of glial cell involved in various aspects of nervous system infrastructure, from the metabolic and structural support of neurons to direct neuromodulation of synaptic activity. Investigating how astrocytes behave in functionally related circuits...

The impact of (ab)normal maternal environment on cortical development.

Progress in neurobiology

Vasistha NA, Khodosevich K.
PMID: 33905709
Prog Neurobiol. 2021 Jul;202:102054. doi: 10.1016/j.pneurobio.2021.102054. Epub 2021 Apr 24.

The cortex in the mammalian brain is the most complex brain region that integrates sensory information and coordinates motor and cognitive processes. To perform such functions, the cortex contains multiple subtypes of neurons that are generated during embryogenesis. Newly...

Erratum to: "Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE ε4, sex and age" [Prog. Neurobiol. 198 (2021) 101904].

Progress in neurobiology

Ayton S, Janelidze S, Roberts B, Palmqvist S, Kalinowski P, Diouf I, Belaidi AA, Stomrud E, Bush AI, Hansson O.
PMID: 33966892
Prog Neurobiol. 2021 Sep;204:102071. doi: 10.1016/j.pneurobio.2021.102071. Epub 2021 May 07.

No abstract available.

Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke.

Progress in neurobiology

Song S, Huang H, Guan X, Fiesler V, Bhuiyan MIH, Liu R, Jalali S, Hasan MN, Tai AK, Chattopadhyay A, Chaparala S, Sun M, Stolz DB, He P, Agalliu D, Sun D, Begum G.
PMID: 33249091
Prog Neurobiol. 2021 Apr;199:101963. doi: 10.1016/j.pneurobio.2020.101963. Epub 2020 Nov 26.

The role of astrocytes in dysregulation of blood-brain barrier (BBB) function following ischemic stroke is not well understood. Here, we investigate the effects of restoring the repair properties of astrocytes on the BBB after ischemic stroke. Mice deficient for...

Macrophagic and microglial complexity after neuronal injury.

Progress in neurobiology

Mesquida-Veny F, Del Río JA, Hervera A.
PMID: 33358752
Prog Neurobiol. 2021 May;200:101970. doi: 10.1016/j.pneurobio.2020.101970. Epub 2020 Dec 20.

Central nervous system (CNS) injuries do not heal properly in contrast to normal tissue repair, in which functional recovery typically occurs. The reason for this dichotomy in wound repair is explained in part by macrophage and microglial malfunction, affecting...

Higher and deeper: Bringing layer fMRI to association cortex.

Progress in neurobiology

Finn ES, Huber L, Bandettini PA.
PMID: 33091541
Prog Neurobiol. 2020 Oct 19;101930. doi: 10.1016/j.pneurobio.2020.101930. Epub 2020 Oct 19.

Recent advances in fMRI have enabled non-invasive measurements of brain function in awake, behaving humans at unprecedented spatial resolutions, allowing us to separate activity in distinct cortical layers. While most layer fMRI studies to date have focused on primary...

The thalamus integrates the macrosystems of the brain to facilitate complex, adaptive brain network dynamics.

Progress in neurobiology

Shine JM.
PMID: 33189781
Prog Neurobiol. 2021 Apr;199:101951. doi: 10.1016/j.pneurobio.2020.101951. Epub 2020 Nov 13.

The human brain is a complex, adaptive system comprised of billions of cells with trillions of connections. The interactions between the elements of the system oppose this seemingly limitless capacity by constraining the system's dynamic repertoire, enforcing distributed neural...

Layer-dependent multiplicative effects of spatial attention on contrast responses in human early visual cortex.

Progress in neurobiology

Liu C, Guo F, Qian C, Zhang Z, Sun K, Wang DJ, He S, Zhang P.
PMID: 32818495
Prog Neurobiol. 2021 Dec;207:101897. doi: 10.1016/j.pneurobio.2020.101897. Epub 2020 Aug 17.

Attention mechanisms at different cortical layers of human visual cortex remain poorly understood. Using submillimeter-resolution fMRI at 7 Tesla, we investigated the effects of top-down spatial attention on the contrast responses across different cortical depths in human early visual...

Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties.

Progress in neurobiology

Christensen J, Yamakawa GR, Shultz SR, Mychasiuk R.
PMID: 32991958
Prog Neurobiol. 2021 Mar;198:101917. doi: 10.1016/j.pneurobio.2020.101917. Epub 2020 Sep 28.

Until recently, both the purpose of the biological need for sleep and the mechanism by which the central nervous system eliminated metabolic waste products were unknown. The glymphatic system is the recently discovered macroscopic waste clearance system for the...

Combining robotics with enhanced serotonin-driven cortical plasticity improves post-stroke motor recovery.

Progress in neurobiology

Conti S, Spalletti C, Pasquini M, Giordano N, Barsotti N, Mainardi M, Lai S, Giorgi A, Pasqualetti M, Micera S, Caleo M.
PMID: 33984455
Prog Neurobiol. 2021 Aug;203:102073. doi: 10.1016/j.pneurobio.2021.102073. Epub 2021 May 11.

Despite recent progresses in robotic rehabilitation technologies, their efficacy for post-stroke motor recovery is still limited. Such limitations might stem from the insufficient enhancement of plasticity mechanisms, crucial for functional recovery. Here, we designed a clinically relevant strategy that...

Showing 13 to 24 of 213 entries