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Showing 25 to 36 of 213 entries
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Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury.

Progress in neurobiology

Kim N, Wang B, Koikawa K, Nezu Y, Qiu C, Lee TH, Zhou XZ.
PMID: 33979671
Prog Neurobiol. 2021 Aug;203:102072. doi: 10.1016/j.pneurobio.2021.102072. Epub 2021 May 09.

Traumatic brain injury (TBI) is the leading cause of mortality and disability in young people and may lead to the development of progressive neurodegeneration, such as that observed in chronic traumatic encephalopathy. We have recently found that the conformation-specific...

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism.

Progress in neurobiology

Scekic-Zahirovic J, Fischer M, Stuart-Lopez G, Burg T, Gilet J, Dirrig-Grosch S, Marques C, Birling MC, Kessler P, Rouaux C.
PMID: 33309802
Prog Neurobiol. 2021 May;200:101972. doi: 10.1016/j.pneurobio.2020.101972. Epub 2020 Dec 09.

Amyotrophic lateral sclerosis (ALS) arises from the combined degeneration of motor neurons (MN) and corticospinal neurons (CSN). Recent clinical and pathological studies suggest that ALS might start in the motor cortex and spread along the corticofugal axonal projections (including...

Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models.

Progress in neurobiology

Franklin H, Clarke BE, Patani R.
PMID: 33309801
Prog Neurobiol. 2021 May;200:101973. doi: 10.1016/j.pneurobio.2020.101973. Epub 2020 Dec 09.

Both astrocytes and microglia fulfil homeostatic and immune functions in the healthy CNS. Dysfunction of these cell types have been implicated in the pathomechanisms of several neurodegenerative diseases. Understanding the cellular autonomy and early pathological changes in these cell...

Brain preparedness: The proactive role of the cortisol awakening response in hippocampal-prefrontal functional interactions.

Progress in neurobiology

Xiong B, Chen C, Tian Y, Zhang S, Liu C, Evans TM, Fernández G, Wu J, Qin S.
PMID: 34343631
Prog Neurobiol. 2021 Oct;205:102127. doi: 10.1016/j.pneurobio.2021.102127. Epub 2021 Jul 31.

Upon awakening from nighttime sleep, the stress hormone cortisol in humans exhibits a robust rise within thirty to forty-five minutes. This cortisol awakening response (CAR), a crucial point of reference within the healthy cortisol circadian rhythm, has been linked...

Preattentive processing of visually guided self-motion in humans and monkeys.

Progress in neurobiology

Schmitt C, Schwenk JCB, Schütz A, Churan J, Kaminiarz A, Bremmer F.
PMID: 34224808
Prog Neurobiol. 2021 Oct;205:102117. doi: 10.1016/j.pneurobio.2021.102117. Epub 2021 Jul 02.

The visually-based control of self-motion is a challenging task, requiring - if needed - immediate adjustments to keep on track. Accordingly, it would appear advantageous if the processing of self-motion direction (heading) was predictive, thereby accelerating the encoding of...

Functional organization of spatial frequency tuning in macaque V1 revealed with two-photon calcium imaging.

Progress in neurobiology

Guan SC, Ju NS, Tao L, Tang SM, Yu C.
PMID: 34252470
Prog Neurobiol. 2021 Oct;205:102120. doi: 10.1016/j.pneurobio.2021.102120. Epub 2021 Jul 09.

V1 neurons are functionally organized in orientation columns in primates. Whether spatial frequency (SF) columns also exist is less clear because mixed results have been reported. A definitive solution would be SF functional maps at single-neuron resolution. Here we...

Temporally coherent perturbation of neural dynamics during retention alters human multi-item working memory.

Progress in neurobiology

Li J, Huang Q, Han Q, Mi Y, Luo H.
PMID: 33617918
Prog Neurobiol. 2021 Jun;201:102023. doi: 10.1016/j.pneurobio.2021.102023. Epub 2021 Feb 19.

Temporarily storing a list of items in working memory (WM), a fundamental ability in cognition, has been posited to rely on the temporal dynamics of multi-item neural representations during retention. However, the causal evidence, particularly in human subjects, is...

LSD1-BDNF activity in lateral hypothalamus-medial forebrain bundle area is essential for reward seeking behavior.

Progress in neurobiology

Sagarkar S, Choudhary AG, Balasubramanian N, Awathale SN, Somalwar AR, Pawar N, Kokare DM, Subhedar NK, Sakharkar AJ.
PMID: 33798614
Prog Neurobiol. 2021 Jul;202:102048. doi: 10.1016/j.pneurobio.2021.102048. Epub 2021 Mar 30.

Reward induces activity-dependant gene expression and synaptic plasticity-related changes. Lysine-specific histone demethylase 1 (LSD1), a key enzyme driving histone modifications, regulates transcription in neural circuits of memory and emotional behavior. Herein, we focus on the role of LSD1 in...

Estrogen-dependent hippocampal wiring as a risk factor for age-related dementia in women.

Progress in neurobiology

Torromino G, Maggi A, De Leonibus E.
PMID: 32781107
Prog Neurobiol. 2021 Feb;197:101895. doi: 10.1016/j.pneurobio.2020.101895. Epub 2020 Aug 08.

Women are more prone than men to develop age-related dementia, such as Alzheimer's disease (AD). This has been linked to the marked decrease in circulating estrogens during menopause. This review proposes to change this perspective and consider women's vulnerability...

Layer-dependent multiplicative effects of spatial attention on contrast responses in human early visual cortex.

Progress in neurobiology

Liu C, Guo F, Qian C, Zhang Z, Sun K, Wang DJ, He S, Zhang P.
PMID: 32818495
Prog Neurobiol. 2020 Aug 17;101897. doi: 10.1016/j.pneurobio.2020.101897. Epub 2020 Aug 17.

Attention mechanisms at different cortical layers of human visual cortex remain poorly understood. Using submillimeter-resolution fMRI at 7 Tesla, we investigated the effects of top-down spatial attention on the contrast responses across different cortical depths in human early visual...

Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling.

Progress in neurobiology

Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM, Khoutorsky A, Gkogkas CG.
PMID: 32860876
Prog Neurobiol. 2021 Feb;197:101903. doi: 10.1016/j.pneurobio.2020.101903. Epub 2020 Aug 26.

Contextual fear conditioning (CFC) in rodents is the most widely used behavioural paradigm in neuroscience research to elucidate the neurobiological mechanisms underlying learning and memory. It is based on the pairing of an aversive unconditioned stimulus (US; e.g. mild...

New perspectives on healthy aging.

Progress in neurobiology

Jin K.
PMID: 28918824
Prog Neurobiol. 2017 Oct;157:1. doi: 10.1016/j.pneurobio.2017.08.006.

No abstract available.

Showing 25 to 36 of 213 entries