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Showing 25 to 36 of 90 entries
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Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease.

Fluids and barriers of the CNS

Patton SM, Cho YW, Clardy TW, Allen RP, Earley CJ, Connor JR.
PMID: 23758918
Fluids Barriers CNS. 2013 Jun 07;10(1):20. doi: 10.1186/2045-8118-10-20.

BACKGROUND: Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a sensorimotor disorder that causes patients to experience overwhelming and distressing sensations in the legs compelling the patient to move their legs to provide relief. The purpose of this study was to...

Release and inhibitory effects of prostaglandin D2 in guinea pig urinary bladder and the role of urothelium.

Biochimica et biophysica acta

Guan NN, Nilsson KF, Wiklund PN, Gustafsson LE.
PMID: 25224734
Biochim Biophys Acta. 2014 Dec;1840(12):3443-51. doi: 10.1016/j.bbagen.2014.09.010. Epub 2014 Sep 16.

BACKGROUND: While studying a urothelium-derived inhibitory factor in guinea pig urinary bladders we observed considerable release of prostanoids, including PGD2-like activity. The present study was carried out to identify the prostanoids and to study their roles in modulating guinea...

HIV gp120 Induces the Release of Proinflammatory, Angiogenic, and Lymphangiogenic Factors from Human Lung Mast Cells.

Vaccines

Marone G, Rossi FW, Pecoraro A, Pucino V, Criscuolo G, Paulis A, Spadaro G, Marone G, Varricchi G.
PMID: 32375243
Vaccines (Basel). 2020 May 03;8(2). doi: 10.3390/vaccines8020208.

Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are involved in chronic pulmonary diseases occurring at high frequency among HIV-infected individuals. Immunoglobulin superantigens bind to the variable regions of either the heavy or light...

ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice.

Hepatology communications

Sala M, Gonzales D, Leste-Lasserre T, Dugot-Senant N, Paradis V, Di Tommaso S, Dupuy JW, Pitard V, Dourthe C, Sciarra A, Sempoux C, Ferrell LD, Clouston AD, Miller G, Yeh MM, Thung S, Gouw ASH, Quaglia A, Han J, Huan J, Fan C, Crawford J, Nakanuma Y, Harada K, le Bail B, Castain C, Frulio N, Trillaud H, Possenti L, Blanc JF, Chiche L, Laurent C, Balabaud C, Bioulac-Sage P, Raymond AA, Saltel F.
PMID: 32490318
Hepatol Commun. 2020 Apr 11;4(6):809-824. doi: 10.1002/hep4.1514. eCollection 2020 Jun.

Until recently, 10% of hepatocellular adenomas (HCAs) remained unclassified (UHCA). Among the UHCAs, the sonic hedgehog HCA (shHCA) was defined by focal deletions that fuse the promoter of Inhibin beta E chain with GLI1. Prostaglandin D2 synthase was proposed...

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.

Cell metabolism

Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J.
PMID: 33811820
Cell Metab. 2021 Jun 01;33(6):1124-1136.e5. doi: 10.1016/j.cmet.2021.03.008. Epub 2021 Apr 02.

Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embryogenesis,...

Divergent PGD.

Prostaglandins & other lipid mediators

Butterfield JH, Singh RJ.
PMID: 34029712
Prostaglandins Other Lipid Mediat. 2021 Aug;155:106563. doi: 10.1016/j.prostaglandins.2021.106563. Epub 2021 May 21.

Aspirin-exacerbated respiratory disease and some cases of chronic idiopathic urticaria are disorders in which increased baseline urinary excretion of leukotriene(LT)E4 further increases following aspirin administration. Increased urinary excretion of the metabolites of prostaglandin D2, 11β-prostaglandin(PG)F2α and (2,3-dinor)-11β-PGF2α, have been...

Prostaglandin D.

The Korean journal of pain

Li Y, Kim WM, Kim SH, You HE, Kang DH, Lee HG, Choi JI, Yoon MH.
PMID: 33380565
Korean J Pain. 2021 Jan 01;34(1):27-34. doi: 10.3344/kjp.2021.34.1.27.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomechanisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we assessed the role of prostaglandin DMETHODS: CIPN was induced by...

The Montelukast Therapy in Asthmatic Children with and without Food Allergy: Does It Make Any Difference?.

International archives of allergy and immunology

Sahiner UM, Arik Yilmaz E, Fontanella S, Haider S, Soyer O, Custovic A, Kalayci O, Sackesen C.
PMID: 34518469
Int Arch Allergy Immunol. 2021;182(12):1212-1221. doi: 10.1159/000517865. Epub 2021 Sep 09.

INTRODUCTION: Children with food allergy are at increased risk for asthma and asthma morbidity. Since leukotrienes are implicated in the pathogenesis of both asthma and probably in food allergies, we hypothesized that asthmatic children with concomitant food allergy may...

Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling.

Cell death and differentiation

Hu S, Ren S, Cai Y, Liu J, Han Y, Zhao Y, Yang J, Zhou X, Wang X.
PMID: 34743203
Cell Death Differ. 2021 Nov 06; doi: 10.1038/s41418-021-00880-2. Epub 2021 Nov 06.

Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalin superfamily and plays dual roles in prostaglandins metabolism and lipid transport. PTGDS has been involved in various cellular processes including the tumorigenesis of solid tumors, yet its role...

In the mouse, prostaglandin D2 signalling protects the endometrium against adenomyosis.

Molecular human reproduction

Philibert P, Déjardin S, Pirot N, Pruvost A, Nguyen AL, Bernex F, Poulat F, Boizet-Bonhoure B.
PMID: 33851217
Mol Hum Reprod. 2021 May 08;27(5). doi: 10.1093/molehr/gaab029.

Adenomyosis is characterised by epithelial gland and mesenchymal stroma invasion of the uterine myometrium. Adenomyosis is an oestrogen-dependent gynaecological disease in which a number of factors, such as inflammatory molecules, prostaglandins (PGs), angiogenic factors, cell proliferation and extracellular matrix...

Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters.

Clinical Medicine Insights. Cardiology

Vosper H.
PMID: 22084607
Clin Med Insights Cardiol. 2011;5:85-101. doi: 10.4137/CMC.S7601. Epub 2011 Sep 19.

The progression of atherosclerosis remains a major cause of morbidity and mortality. Plaque formation is an immunological response driven by a number of risk factors, and reduction of risk is the primary goal of treatment. The role of LDL-C...

Prostaglandin D2 synthase/prostaglandin D2/TWIST2 signaling inhibits breast cancer proliferation.

Anti-cancer drugs

Pan J, Zhang L, Huang J.
PMID: 34232948
Anticancer Drugs. 2021 Nov 01;32(10):1029-1037. doi: 10.1097/CAD.0000000000001111.

Though the past few years have witnessed exciting achievements in targeted and immunotherapeutic treatments of all breast cancer subtypes, yet the decline in breast cancer mortality has been slowed, urging the need for further expanding options of high-quality treatments....

Showing 25 to 36 of 90 entries