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The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways.

Free radical biology & medicine

Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S.
PMID: 34848369
Free Radic Biol Med. 2021 Nov 27;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27.

SCOPE: The long-chain metabolites of (LCM) vitamin E are proposed as the active regulatory metabolites of vitamin E providing, with their anti-inflammatory properties, an explanatory approach for the inconsistent effects of vitamin E on inflammatory-driven diseases. We examined the...

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Schubert M, Kluge S, Brunner E, et al. The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. Free Radic Biol Med. 2021;178:83-96doi: 10.1016/j.freeradbiomed.2021.11.032.
Schubert, M., Kluge, S., Brunner, E., Pace, S., Birringer, M., Werz, O., & Lorkowski, S. (2021). The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. Free radical biology & medicine, 17883-96. https://doi.org/10.1016/j.freeradbiomed.2021.11.032
Schubert, Martin, et al. "The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways." Free radical biology & medicine vol. 178 (2021): 83-96. doi: https://doi.org/10.1016/j.freeradbiomed.2021.11.032
Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S. The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. Free Radic Biol Med. 2021 Nov 27;178:83-96. doi: 10.1016/j.freeradbiomed.2021.11.032. Epub 2021 Nov 27. PMID: 34848369.
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Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors.

Molecular immunology

Fang X, Li M, Zhang W, Li J, Zhu T.
PMID: 34808483
Mol Immunol. 2021 Nov 19;141:60-69. doi: 10.1016/j.molimm.2021.11.012. Epub 2021 Nov 19.

Thrombin-induced mast cell activation represents cross-talk between coagulation and inflammation. However, there is still controversy concerning the pro- or anti-inflammatory effects mast cells have in response to thrombin signaling. Human mast cell HMC-1 was incubated with 0.2 U/mL thrombin....

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Fang X, Li M, Zhang W, et al. Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors. Mol Immunol. 2021;141:60-69doi: 10.1016/j.molimm.2021.11.012.
Fang, X., Li, M., Zhang, W., Li, J., & Zhu, T. (2021). Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors. Molecular immunology, 14160-69. https://doi.org/10.1016/j.molimm.2021.11.012
Fang, Xiaobin, et al. "Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors." Molecular immunology vol. 141 (2021): 60-69. doi: https://doi.org/10.1016/j.molimm.2021.11.012
Fang X, Li M, Zhang W, Li J, Zhu T. Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors. Mol Immunol. 2021 Nov 19;141:60-69. doi: 10.1016/j.molimm.2021.11.012. Epub 2021 Nov 19. PMID: 34808483.
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Chemical Probes for Understudied Kinases: Challenges and Opportunities.

Journal of medicinal chemistry

Serafim RAM, Elkins JM, Zuercher WJ, Laufer SA, Gehringer M.
PMID: 34477374
J Med Chem. 2021 Sep 03; doi: 10.1021/acs.jmedchem.1c00980. Epub 2021 Sep 03.

Over 20 years after the approval of the first-in-class protein kinase inhibitor imatinib, the biological function of a significant fraction of the human kinome remains poorly understood while most research continues to be focused on few well-validated targets. Given...

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Serafim RAM, Elkins JM, Zuercher WJ, et al. Chemical Probes for Understudied Kinases: Challenges and Opportunities. J Med Chem. 2021;doi: 10.1021/acs.jmedchem.1c00980.
Serafim, R. A. M., Elkins, J. M., Zuercher, W. J., Laufer, S. A., & Gehringer, M. (2021). Chemical Probes for Understudied Kinases: Challenges and Opportunities. Journal of medicinal chemistry, . https://doi.org/10.1021/acs.jmedchem.1c00980
Serafim, Ricardo A M, et al. "Chemical Probes for Understudied Kinases: Challenges and Opportunities." Journal of medicinal chemistry vol. (2021). doi: https://doi.org/10.1021/acs.jmedchem.1c00980
Serafim RAM, Elkins JM, Zuercher WJ, Laufer SA, Gehringer M. Chemical Probes for Understudied Kinases: Challenges and Opportunities. J Med Chem. 2021 Sep 03; doi: 10.1021/acs.jmedchem.1c00980. Epub 2021 Sep 03. PMID: 34477374.
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Role of MicroRNAs and their corresponding ACE2/Apelin signaling pathways in hypertension.

Microbial pathogenesis

Ali F, Shen A, Islam W, Saleem MZ, Muthu R, Xie Q, Wu M, Cheng Y, Chu J, Lin W, Peng J.
PMID: 34919993
Microb Pathog. 2021 Dec 15;162:105361. doi: 10.1016/j.micpath.2021.105361. Epub 2021 Dec 15.

Hypertension is controlled via the alteration of microRNAs (miRNAs), their therapeutic targets angiotensin II type I receptor (AT1R) and cross talk of signaling pathways. The stimulation of the Ang II/AT1R pathway by deregulation of miRNAs, has also been linked...

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Ali F, Shen A, Islam W, et al. Role of MicroRNAs and their corresponding ACE2/Apelin signaling pathways in hypertension. Microb Pathog. 2021;162:105361doi: 10.1016/j.micpath.2021.105361.
Ali, F., Shen, A., Islam, W., Saleem, M. Z., Muthu, R., Xie, Q., Wu, M., Cheng, Y., Chu, J., Lin, W., & Peng, J. (2021). Role of MicroRNAs and their corresponding ACE2/Apelin signaling pathways in hypertension. Microbial pathogenesis, 162105361. https://doi.org/10.1016/j.micpath.2021.105361
Ali, Farman, et al. "Role of MicroRNAs and their corresponding ACE2/Apelin signaling pathways in hypertension." Microbial pathogenesis vol. 162 (2021): 105361. doi: https://doi.org/10.1016/j.micpath.2021.105361
Ali F, Shen A, Islam W, Saleem MZ, Muthu R, Xie Q, Wu M, Cheng Y, Chu J, Lin W, Peng J. Role of MicroRNAs and their corresponding ACE2/Apelin signaling pathways in hypertension. Microb Pathog. 2021 Dec 15;162:105361. doi: 10.1016/j.micpath.2021.105361. Epub 2021 Dec 15. PMID: 34919993.
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Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Kim JW, Kim JH, Kim CY, Jeong JS, Lim JO, Kim JC, Ko JW, Kim TW.
PMID: 34999178
Food Chem Toxicol. 2022 Jan 06;160:112814. doi: 10.1016/j.fct.2022.112814. Epub 2022 Jan 06.

We investigated whether diallyl disulfide (DADS) has protective effects against 1,3-dichloro-2-propanol (1,3-DCP)-induced hepatotoxicity and oxidative damage in rats and HepG2 cells. DADS was administered to rats once daily for 7 days at doses of 30 and 60 mg/kg/day. One...

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Kim JW, Kim JH, Kim CY, et al. Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling. Food Chem Toxicol. 2022;160:112814doi: 10.1016/j.fct.2022.112814.
Kim, J. W., Kim, J. H., Kim, C. Y., Jeong, J. S., Lim, J. O., Kim, J. C., Ko, J. W., & Kim, T. W. (2022). Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 160112814. https://doi.org/10.1016/j.fct.2022.112814
Kim, Jeong-Won, et al. "Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol. 160 (2022): 112814. doi: https://doi.org/10.1016/j.fct.2022.112814
Kim JW, Kim JH, Kim CY, Jeong JS, Lim JO, Kim JC, Ko JW, Kim TW. Diallyl disulfide prevents 1,3-dichloro-2-propanol-induced hepatotoxicity through mitogen-activated protein kinases signaling. Food Chem Toxicol. 2022 Jan 06;160:112814. doi: 10.1016/j.fct.2022.112814. Epub 2022 Jan 06. PMID: 34999178.
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Arabidopsis cysteine-rich receptor-like protein kinase .

Plant signaling & behavior

Arellano-Villagómez FC, Guevara-Olvera L, Zuñiga-Mayo VM, E Cerbantez-Bueno V, Verdugo-Perales M, R Medina H, De Folter S, Acosta-García G.
PMID: 33769202
Plant Signal Behav. 2021 Jun 03;16(6):1905335. doi: 10.1080/15592324.2021.1905335. Epub 2021 Mar 26.

Cysteine-rich receptor-like protein kinases (CRKs) are transmembrane proteins containing two domains of unknown function 26 (DUF26) RLKs in their ectodomain. Despite that CRKs control important aspects of plant development, only few proteins have functionally been characterized. In this work,...

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Arellano-Villagómez FC, Guevara-Olvera L, Zuñiga-Mayo VM, et al. Arabidopsis cysteine-rich receptor-like protein kinase . Plant Signal Behav. 2021;16(6):1905335doi: 10.1080/15592324.2021.1905335.
Arellano-Villagómez, F. C., Guevara-Olvera, L., Zuñiga-Mayo, V. M., E Cerbantez-Bueno, V., Verdugo-Perales, M., R Medina, H., De Folter, S., & Acosta-García, G. (2021). Arabidopsis cysteine-rich receptor-like protein kinase . Plant signaling & behavior, 16(6), 1905335. https://doi.org/10.1080/15592324.2021.1905335
Arellano-Villagómez, Flor Cristina, et al. "Arabidopsis cysteine-rich receptor-like protein kinase ." Plant signaling & behavior vol. 16,6 (2021): 1905335. doi: https://doi.org/10.1080/15592324.2021.1905335
Arellano-Villagómez FC, Guevara-Olvera L, Zuñiga-Mayo VM, E Cerbantez-Bueno V, Verdugo-Perales M, R Medina H, De Folter S, Acosta-García G. Arabidopsis cysteine-rich receptor-like protein kinase . Plant Signal Behav. 2021 Jun 03;16(6):1905335. doi: 10.1080/15592324.2021.1905335. Epub 2021 Mar 26. PMID: 33769202; PMCID: PMC8143253.
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Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes.

Diabetes

Chen YL, Ren Y, Rosa RH, Kuo L, Hein TW.
PMID: 34353852
Diabetes. 2021 Oct;70(10):2353-2363. doi: 10.2337/db20-0889. Epub 2021 Aug 05.

Diabetes elevates endothelin-1 (ET-1) in the vitreous and enhances constriction of retinal venules to this peptide. However, mechanisms contributing to ET-1-induced constriction of retinal venules are incompletely understood. We examined roles of sodium-hydrogen exchanger 1 (NHE1), protein kinase C...

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Chen YL, Ren Y, Rosa RH, et al. Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes. Diabetes. 2021;70(10):2353-2363doi: 10.2337/db20-0889.
Chen, Y. L., Ren, Y., Rosa, R. H., Kuo, L., & Hein, T. W. (2021). Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes. Diabetes, 70(10), 2353-2363. https://doi.org/10.2337/db20-0889
Chen, Yen-Lin, et al. "Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes." Diabetes vol. 70,10 (2021): 2353-2363. doi: https://doi.org/10.2337/db20-0889
Chen YL, Ren Y, Rosa RH, Kuo L, Hein TW. Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes. Diabetes. 2021 Oct;70(10):2353-2363. doi: 10.2337/db20-0889. Epub 2021 Aug 05. PMID: 34353852; PMCID: PMC8576499.
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Identification and characterization of mkk genes and their expression profiles in rainbow trout (Oncorhynchus mykiss) symptomatically or asymptomatically infected with Vibrio anguillarum.

Fish & shellfish immunology

Yang XD, Hou ZS, Liu MQ, Zeng C, Zhao HK, Xin YR, Xiang KW, Yang Q, Wen HS, Li JF.
PMID: 34974153
Fish Shellfish Immunol. 2021 Dec 31;121:1-11. doi: 10.1016/j.fsi.2021.12.049. Epub 2021 Dec 31.

Mitogen-activated protein kinase kinases (MKKs) are intermediate kinases of mitogen-activated protein kinases (MAPKs) signaling pathways. MKKs are activated by mitogen-activated protein kinase kinase kinase (MKKK) and then the activated MKKs trigger the activation of downstream MAPKs. MAPK signaling pathways...

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Yang XD, Hou ZS, Liu MQ, et al. Identification and characterization of mkk genes and their expression profiles in rainbow trout (Oncorhynchus mykiss) symptomatically or asymptomatically infected with Vibrio anguillarum. Fish Shellfish Immunol. 2021;121:1-11doi: 10.1016/j.fsi.2021.12.049.
Yang, X. D., Hou, Z. S., Liu, M. Q., Zeng, C., Zhao, H. K., Xin, Y. R., Xiang, K. W., Yang, Q., Wen, H. S., & Li, J. F. (2021). Identification and characterization of mkk genes and their expression profiles in rainbow trout (Oncorhynchus mykiss) symptomatically or asymptomatically infected with Vibrio anguillarum. Fish & shellfish immunology, 1211-11. https://doi.org/10.1016/j.fsi.2021.12.049
Yang, Xiao-Dong, et al. "Identification and characterization of mkk genes and their expression profiles in rainbow trout (Oncorhynchus mykiss) symptomatically or asymptomatically infected with Vibrio anguillarum." Fish & shellfish immunology vol. 121 (2021): 1-11. doi: https://doi.org/10.1016/j.fsi.2021.12.049
Yang XD, Hou ZS, Liu MQ, Zeng C, Zhao HK, Xin YR, Xiang KW, Yang Q, Wen HS, Li JF. Identification and characterization of mkk genes and their expression profiles in rainbow trout (Oncorhynchus mykiss) symptomatically or asymptomatically infected with Vibrio anguillarum. Fish Shellfish Immunol. 2021 Dec 31;121:1-11. doi: 10.1016/j.fsi.2021.12.049. Epub 2021 Dec 31. PMID: 34974153.
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Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes.

Cell journal

Zhou L, Ye H, Liu L, Chen Y.
PMID: 34455725
Cell J. 2021 Sep;23(4):485-494. doi: 10.22074/cellj.2021.7127. Epub 2021 Aug 29.

OBJECTIVE: Human bone marrow mesenchymal stem cell (hBMSC)-derived exosomes exhibit protective effects against inflammatory diseases. This study aimed to explore the effects of hBMSC-derived exosomes on osteoarthritis (OA) MATERIALS AND METHODS: In this experimental study, we characterised exosomes derived...

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Zhou L, Ye H, Liu L, et al. Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes. Cell J. 2021;23(4):485-494doi: 10.22074/cellj.2021.7127.
Zhou, L., Ye, H., Liu, L., & Chen, Y. (2021). Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes. Cell journal, 23(4), 485-494. https://doi.org/10.22074/cellj.2021.7127
Zhou, Liping, et al. "Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes." Cell journal vol. 23,4 (2021): 485-494. doi: https://doi.org/10.22074/cellj.2021.7127
Zhou L, Ye H, Liu L, Chen Y. Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes. Cell J. 2021 Sep;23(4):485-494. doi: 10.22074/cellj.2021.7127. Epub 2021 Aug 29. PMID: 34455725; PMCID: PMC8405079.
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RUI: Cell Wall Associated Protein Kinases and Cell Elongation.

[No authors listed]
UIID-NSF: 957

The plant Wall Associated Kinases,WAKs, which were discovered by Dr. Kohorn, are phosphorylating enzyme proteins that physically link the plasma membrane to the carbohydrate and protein matrix that comprises the plant cell wall. WAKs are of importance as they...

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RUI: Cell Wall Associated Protein Kinases and Cell Elongation. ;
(). RUI: Cell Wall Associated Protein Kinases and Cell Elongation. .
"RUI: Cell Wall Associated Protein Kinases and Cell Elongation." vol. ().
RUI: Cell Wall Associated Protein Kinases and Cell Elongation. UIID-NSF: 957.
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Showing 2257 to 2266 of 2266 entries