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Showing 13 to 22 of 22 entries
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DMSO Delays Alzheimer Disease Causing Aβ-induced Paralysis in .

Annals of neurosciences

Sadananda G, Velmurugan JD, Subramaniam JR.
PMID: 34733055
Ann Neurosci. 2021 Jan;28(1):55-64. doi: 10.1177/09727531211046369. Epub 2021 Oct 05.

BACKGROUND: Alzheimer's disease (AD), a prevalent neurodegenerative disease with progressive dementia and neurotransmission (NT)-dysfunction-related complications in older adults, is known to be caused by abnormal Amyloid-β (Aβ) peptide and associated amyloid plaques in the brain. Drugs to cure AD...

Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.

Evidence-based complementary and alternative medicine : eCAM

Del Valle-Mojica LM, Ayala-Marín YM, Ortiz-Sanchez CM, Torres-Hernández BA, Abdalla-Mukhaimer S, Ortiz JG.
PMID: 21584239
Evid Based Complement Alternat Med. 2011;2011:403591. doi: 10.1155/2011/403591. Epub 2011 Apr 26.

Although GABA neurotransmission has been suggested as a mechanism for Valeriana officinalis effects, CNS depression can also be evoked by inhibition of ionotropic (iGluR) and metabotropic glutamate receptors (mGluR). In this study, we examined if aqueous valerian extract interacted...

Excitatory amino acids release endogenous acetylcholine from rat striatal slices: Regulation by gamma-aminobutyric acid.

Neurochemistry international

Alberch J, Arenas E, Sánchez Arroyos R, Marsal J.
PMID: 20504609
Neurochem Int. 1990;17(1):107-16. doi: 10.1016/0197-0186(90)90074-4.

Endogenous acetylcholine release from rat striatal slices in response to several excitatory amino acids and its regulation by gamma-aminobutyric acid were investigated using a chemiluminescent reaction to detect this release continuously. The amount of acetylcholine released by glutamate (1...

Differential effects of lithium on agonist-stimulated inositol polyphosphate formation in rat cerebral cortex slices: Selective actions on muscarinic cholinergic responses.

Neurochemistry international

Godfrey PP, Taghavi Z, Parfrey H, Grahame-Smith DG.
PMID: 20504653
Neurochem Int. 1990;17(4):515-22. doi: 10.1016/0197-0186(90)90038-u.

The effect of lithium ions on agonist-stimulated inositol polyphosphate production was investigated in slices of rat cerebral cortex. LiCl potentiated the formation of inositol monophosphate and inositol bisphosphate following stimulation with a variety of agonists including carbachol (1 mM),...

Predifferentiated GABAergic neural precursor transplants for alleviation of dysesthetic central pain following excitotoxic spinal cord injury.

Frontiers in physiology

Lee JW, Jergova S, Furmanski O, Gajavelli S, Sagen J.
PMID: 22754531
Front Physiol. 2012 May 31;3:167. doi: 10.3389/fphys.2012.00167. eCollection 2012.

Intraspinal quisqualic acid (QUIS) injury induce (i) mechanical and thermal hyperalgesia, (ii) progressive self-injurious overgrooming of the affected dermatome. The latter is thought to resemble painful dysesthesia observed in spinal cord injury (SCI) patients. We have reported previously loss...

Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties.

Beilstein journal of organic chemistry

Maftei CV, Fodor E, Jones PG, Franz MH, Kelter G, Fiebig H, Neda I.
PMID: 24222789
Beilstein J Org Chem. 2013 Oct 25;9:2202-15. doi: 10.3762/bjoc.9.259. eCollection 2013.

Taking into consideration the biological activity of the only natural products containing a 1,2,4-oxadiazole ring in their structure (quisqualic acid and phidianidines A and B), the natural product analogs 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)pyrrolidine-2,5-dione (4) and 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-pyrrole-2,5-dione (7) were synthesized starting from 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)aniline...

Cognitive effects of neurotoxic lesions of the nucleus basalis magnocellularis in rats: differential roles for corticopetal versus amygdalopetal projections.

Neurotoxicity research

Beninger RJ, Dringenberg HC, Boegman RJ, Jhamandas K.
PMID: 15111258
Neurotox Res. 2001 Jan;3(1):7-21. doi: 10.1007/BF03033227.

The cholinergic hypothesis states that cholinergic neurons of the basal forebrain nucleus basalis magnocellularis (nbm) that project to cortical and amygdalar targets play an important role in memory. Biochemical studies have shown that these target areas are differentially sensitive...

Effects of Nucleus Basalis Magnocellularis Lesions in Rats on Delayed Matching and Non-Matching to Position Tasks.

The European journal of neuroscience

Dunnett SB, Rogers DC, Jones GH.
PMID: 12106148
Eur J Neurosci. 1989 Jul;1(4):395-406. doi: 10.1111/j.1460-9568.1989.tb00804.x.

The effects of quisqualic acid lesions of the nucleus basalis magnocellularis on short-term memory capacities of the rat have been investigated using the delayed matching and non-matching to position tasks. The lesions do not disrupt performance of either task...

Multiple neurotransmitter systems influence the release of adenosine derivatives from the rabbit retina.

Neurochemistry international

Thereza M, Perez R, Ehinger B.
PMID: 20504514
Neurochem Int. 1989;15(4):411-20. doi: 10.1016/0197-0186(89)90158-7.

Rabbit retinac preloaded with [(3)H]adenosine were superfused in vitro and the effect of neurotransmitter agonists and antagonists on the release of [(3)H]purines was studied. Glutamic acid, aspartic acid, kainic acid (KA), quisqualic acid (QUIS) and N- methyl- d -aspartic...

The specificity of glutamate inhibition of protein synthesis in synaptosomal fractions from rat cerebral cortex.

Neurochemistry international

Cheung MK.
PMID: 20504497
Neurochem Int. 1989;15(3):293-300. doi: 10.1016/0197-0186(89)90135-6.

In vitro addition of glutamate (GLU) resulted in a dose-dependent inhibition of protein synthesis in synaptosomes from adult rat brain cortex. There was significant (20-25%) inhibition at 25 ?M GLU and a maximum (30-50%) inhibition was observed at [GLU]...

Showing 13 to 22 of 22 entries