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NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation.

Genes & diseases

Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B.
PMID: 34522704
Genes Dis. 2020 Nov 25;8(6):731-745. doi: 10.1016/j.gendis.2020.11.010. eCollection 2021 Nov.

Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT) plays a key role in antioxidant defense by mediating cystine uptake, promoting glutathione synthesis, and maintaining cell survival under oxidative stress conditions. Recent studies showed that,...

Showing 13 to 13 of 13 entries