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Showing 13 to 24 of 37 entries
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Molecular approach to identify antidiabetic potential of Azadirachta indica.

Journal of Ayurveda and integrative medicine

Satyanarayana K, Sravanthi K, Shaker IA, Ponnulakshmi R.
PMID: 26604551
J Ayurveda Integr Med. 2015 Jul-Sep;6(3):165-74. doi: 10.4103/0975-9476.157950.

BACKGROUND: Azadirachta indica (Neem) is a medicinal plant, used in Ayurveda for treating various diseases, one of which is diabetes mellitus. It is known to possess antiinflammatory, antipyretic, antimicrobial, antidiabetic and diverse pharmacological properties. However, the molecular mechanism underlying...

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Satyanarayana K, Sravanthi K, Shaker IA, et al. Molecular approach to identify antidiabetic potential of Azadirachta indica. J Ayurveda Integr Med. 2015;6(3):165-74doi: 10.4103/0975-9476.157950.
Satyanarayana, K., Sravanthi, K., Shaker, I. A., & Ponnulakshmi, R. (2015). Molecular approach to identify antidiabetic potential of Azadirachta indica. Journal of Ayurveda and integrative medicine, 6(3), 165-74. https://doi.org/10.4103/0975-9476.157950
Satyanarayana, K, et al. "Molecular approach to identify antidiabetic potential of Azadirachta indica." Journal of Ayurveda and integrative medicine vol. 6,3 (2015): 165-74. doi: https://doi.org/10.4103/0975-9476.157950
Satyanarayana K, Sravanthi K, Shaker IA, Ponnulakshmi R. Molecular approach to identify antidiabetic potential of Azadirachta indica. J Ayurveda Integr Med. 2015 Jul-Sep;6(3):165-74. doi: 10.4103/0975-9476.157950. PMID: 26604551; PMCID: PMC4630690.
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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics.

Endocrinology and metabolism (Seoul, Korea)

Yoon JH, Kwon KS.
PMID: 34218646
Endocrinol Metab (Seoul). 2021 Jun;36(3):478-490. doi: 10.3803/EnM.2021.1081. Epub 2021 Jun 28.

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are...

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Yoon JH, Kwon KS. Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics. Endocrinol Metab (Seoul). 2021;36(3):478-490doi: 10.3803/EnM.2021.1081.
Yoon, J. H., & Kwon, K. S. (2021). Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics. Endocrinology and metabolism (Seoul, Korea), 36(3), 478-490. https://doi.org/10.3803/EnM.2021.1081
Yoon, Jong Hyeon, and Kwon, Ki-Sun. "Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics." Endocrinology and metabolism (Seoul, Korea) vol. 36,3 (2021): 478-490. doi: https://doi.org/10.3803/EnM.2021.1081
Yoon JH, Kwon KS. Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics. Endocrinol Metab (Seoul). 2021 Jun;36(3):478-490. doi: 10.3803/EnM.2021.1081. Epub 2021 Jun 28. PMID: 34218646; PMCID: PMC8258343.
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Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer.

World journal of clinical oncology

Zhao M, Ramaswamy B.
PMID: 25114842
World J Clin Oncol. 2014 Aug 10;5(3):248-62. doi: 10.5306/wjco.v5.i3.248.

The estrogen receptor (ER) pathway plays a critical role in breast cancer development and progression. Endocrine therapy targeting estrogen action is the most important systemic therapy for ER positive breast cancer. However its efficacy is limited by intrinsic and...

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Zhao M, Ramaswamy B. Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer. World J Clin Oncol. 2014;5(3):248-62doi: 10.5306/wjco.v5.i3.248.
Zhao, M., & Ramaswamy, B. (2014). Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer. World journal of clinical oncology, 5(3), 248-62. https://doi.org/10.5306/wjco.v5.i3.248
Zhao, Meng, and Ramaswamy, Bhuvaneswari. "Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer." World journal of clinical oncology vol. 5,3 (2014): 248-62. doi: https://doi.org/10.5306/wjco.v5.i3.248
Zhao M, Ramaswamy B. Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer. World J Clin Oncol. 2014 Aug 10;5(3):248-62. doi: 10.5306/wjco.v5.i3.248. PMID: 25114842; PMCID: PMC4127598.
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Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging.

Aging and disease

Weissleder C, Barry G, Fung SJ, Wong MW, Double KL, Webster MJ, Weickert CS.
PMID: 30705779
Aging Dis. 2019 Feb 01;10(1):197-204. doi: 10.14336/AD.2018.0317. eCollection 2019 Feb.

The cell proliferation marker, Ki67 and the immature neuron marker, doublecortin are both expressed in the major human neurogenic niche, the subependymal zone (SEZ), but expression progressively decreases across the adult lifespan (PMID: 27932973). In contrast, transcript levels of...

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Weissleder C, Barry G, Fung SJ, et al. Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging. Aging Dis. 2019;10(1):197-204doi: 10.14336/AD.2018.0317.
Weissleder, C., Barry, G., Fung, S. J., Wong, M. W., Double, K. L., Webster, M. J., & Weickert, C. S. (2019). Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging. Aging and disease, 10(1), 197-204. https://doi.org/10.14336/AD.2018.0317
Weissleder, Christin, et al. "Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging." Aging and disease vol. 10,1 (2019): 197-204. doi: https://doi.org/10.14336/AD.2018.0317
Weissleder C, Barry G, Fung SJ, Wong MW, Double KL, Webster MJ, Weickert CS. Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging. Aging Dis. 2019 Feb 01;10(1):197-204. doi: 10.14336/AD.2018.0317. eCollection 2019 Feb. PMID: 30705779; PMCID: PMC6345338.
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Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (.

Open access Macedonian journal of medical sciences

Syafril S, Lindarto D, Lelo A, Sembiring RJ, Saragih A.
PMID: 31110564
Open Access Maced J Med Sci. 2019 Apr 23;7(8):1247-1251. doi: 10.3889/oamjms.2019.218. eCollection 2019 Apr 30.

BACKGROUND: Defects in post-receptor insulin signalling are the major cause of insulin resistance in type 2 diabetes mellitus (T2DM).AIM: This study aimed to investigate the correlations between insulin receptor substrate (IRS)-1 with phosphoinositide 3-kinase (PI3K) and p38 mitogen-activated protein...

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Syafril S, Lindarto D, Lelo A, et al. Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (. Open Access Maced J Med Sci. 2019;7(8):1247-1251doi: 10.3889/oamjms.2019.218.
Syafril, S., Lindarto, D., Lelo, A., Sembiring, R. J., & Saragih, A. (2019). Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (. Open access Macedonian journal of medical sciences, 7(8), 1247-1251. https://doi.org/10.3889/oamjms.2019.218
Syafril, Santi, et al. "Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (." Open access Macedonian journal of medical sciences vol. 7,8 (2019): 1247-1251. doi: https://doi.org/10.3889/oamjms.2019.218
Syafril S, Lindarto D, Lelo A, Sembiring RJ, Saragih A. Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (. Open Access Maced J Med Sci. 2019 Apr 23;7(8):1247-1251. doi: 10.3889/oamjms.2019.218. eCollection 2019 Apr 30. PMID: 31110564; PMCID: PMC6514355.
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Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: A network biology approach.

Journal of cellular biochemistry

Rout M, Lulu S S.
PMID: 30335885
J Cell Biochem. 2018 Oct 18; doi: 10.1002/jcb.27418. Epub 2018 Oct 18.

Discerning the relationship between molecules involved in diseases based on their underlying biological mechanisms is one of the greatest challenges in therapeutic development today. Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, which adversely...

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Rout M, Lulu S S. Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: A network biology approach. J Cell Biochem. 2018;doi: 10.1002/jcb.27418.
Rout, M., & Lulu S, S. (2018). Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: A network biology approach. Journal of cellular biochemistry, . https://doi.org/10.1002/jcb.27418
Rout, Madhusmita, and Lulu S, Sajitha. "Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: A network biology approach." Journal of cellular biochemistry vol. (2018). doi: https://doi.org/10.1002/jcb.27418
Rout M, Lulu S S. Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: A network biology approach. J Cell Biochem. 2018 Oct 18; doi: 10.1002/jcb.27418. Epub 2018 Oct 18. PMID: 30335885.
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Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats.

Iranian journal of basic medical sciences

Liu H, Li N, Jin M, Miao X, Zhang X, Zhong W.
PMID: 32952944
Iran J Basic Med Sci. 2020 Aug;23(8):990-998. doi: 10.22038/ijbms.2020.40859.9650.

OBJECTIVES: Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in elderly type 2 diabetes using...

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Liu H, Li N, Jin M, et al. Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats. Iran J Basic Med Sci. 2020;23(8):990-998doi: 10.22038/ijbms.2020.40859.9650.
Liu, H., Li, N., Jin, M., Miao, X., Zhang, X., & Zhong, W. (2020). Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats. Iranian journal of basic medical sciences, 23(8), 990-998. https://doi.org/10.22038/ijbms.2020.40859.9650
Liu, Hongzhou, et al. "Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats." Iranian journal of basic medical sciences vol. 23,8 (2020): 990-998. doi: https://doi.org/10.22038/ijbms.2020.40859.9650
Liu H, Li N, Jin M, Miao X, Zhang X, Zhong W. Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats. Iran J Basic Med Sci. 2020 Aug;23(8):990-998. doi: 10.22038/ijbms.2020.40859.9650. PMID: 32952944; PMCID: PMC7478262.
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Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina.

Journal of diabetes and clinical research

Jiang Y, Liu L, Li H, Wang JM, Steinle JJ.
PMID: 32432228
J Diabetes Clin Res. 2020;2(1):12-15. Epub 2020 Mar 25.

Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction in a common...

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Jiang Y, Liu L, Li H, et al. Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina. J Diabetes Clin Res. 2020;2(1):12-15
Jiang, Y., Liu, L., Li, H., Wang, J. M., & Steinle, J. J. (2020). Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina. Journal of diabetes and clinical research, 2(1), 12-15.
Jiang, Youde, et al. "Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina." Journal of diabetes and clinical research vol. 2,1 (2020): 12-15.
Jiang Y, Liu L, Li H, Wang JM, Steinle JJ. Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina. J Diabetes Clin Res. 2020;2(1):12-15. Epub 2020 Mar 25. PMID: 32432228; PMCID: PMC7236787.
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Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases.

Current reviews in clinical and experimental pharmacology

Li JTS, Hon KL, Leung AKC, Lee VWY.
PMID: 33069199
Curr Rev Clin Exp Pharmacol. 2021;16(3):239-246. doi: 10.2174/1574884715666201016122612.

BACKGROUND: Green tea has been extensively studied for its potential health benefits against diseases, such as cancers, cognitive degenerative diseases, and cardiovascular diseases.METHODS: The authors undertook a structured search of peer-reviewed research articles from three databases including PubMed, Embase,...

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Li JTS, Hon KL, Leung AKC, et al. Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases. Curr Rev Clin Exp Pharmacol. 2021;16(3):239-246doi: 10.2174/1574884715666201016122612.
Li, J. T. S., Hon, K. L., Leung, A. K. C., & Lee, V. W. Y. (2021). Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases. Current reviews in clinical and experimental pharmacology, 16(3), 239-246. https://doi.org/10.2174/1574884715666201016122612
Li, Joyce T S, et al. "Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases." Current reviews in clinical and experimental pharmacology vol. 16,3 (2021): 239-246. doi: https://doi.org/10.2174/1574884715666201016122612
Li JTS, Hon KL, Leung AKC, Lee VWY. Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases. Curr Rev Clin Exp Pharmacol. 2021;16(3):239-246. doi: 10.2174/1574884715666201016122612. PMID: 33069199.
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Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression.

Journal of clinical biochemistry and nutrition

Kimura K, Katsumata Y, Ozawa T, Tawara S, Igarashi K, Cho Y, Shibata N, Hakuno F, Takahashi S, Takenaka A.
PMID: 20216949
J Clin Biochem Nutr. 2010 Mar;46(2):157-67. doi: 10.3164/jcbn.09-97. Epub 2010 Feb 27.

Oxidative stress is thought to play a role in the development of insulin resistance. In order to elucidate the molecular effect of oxidative stress on liver insulin signaling, we analyzed the effect of paraquat (1,1-dimethyl-4,4-dipyridynium; PQ)-derived oxidative stress on...

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Kimura K, Katsumata Y, Ozawa T, et al. Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression. J Clin Biochem Nutr. 2010;46(2):157-67doi: 10.3164/jcbn.09-97.
Kimura, K., Katsumata, Y., Ozawa, T., Tawara, S., Igarashi, K., Cho, Y., Shibata, N., Hakuno, F., Takahashi, S., & Takenaka, A. (2010). Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression. Journal of clinical biochemistry and nutrition, 46(2), 157-67. https://doi.org/10.3164/jcbn.09-97
Kimura, Kumi, et al. "Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression." Journal of clinical biochemistry and nutrition vol. 46,2 (2010): 157-67. doi: https://doi.org/10.3164/jcbn.09-97
Kimura K, Katsumata Y, Ozawa T, Tawara S, Igarashi K, Cho Y, Shibata N, Hakuno F, Takahashi S, Takenaka A. Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression. J Clin Biochem Nutr. 2010 Mar;46(2):157-67. doi: 10.3164/jcbn.09-97. Epub 2010 Feb 27. PMID: 20216949; PMCID: PMC2831095.
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Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells.

International journal of clinical and experimental medicine

Franklin JL, Keeton AB, Bortoff KD, Messina JL.
PMID: 19079690
Int J Clin Exp Med. 2008;1(1):89-97. Epub 2008 Jan 25.

Insulin regulates metabolism and growth in cells of hepatic origin by specifically binding to and activating the tyrosine kinase insulin receptor. Insulin-induced intracellular signaling is conducted via multiple pathways, including the MAP kinase (MEK/ERK) and the phosphatidylinositol 3-kinase (PI3K)...

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Franklin JL, Keeton AB, Bortoff KD, et al. Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells. Int J Clin Exp Med. 2008;1(1):89-97
Franklin, J. L., Keeton, A. B., Bortoff, K. D., & Messina, J. L. (2008). Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells. International journal of clinical and experimental medicine, 1(1), 89-97.
Franklin, J Lee, et al. "Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells." International journal of clinical and experimental medicine vol. 1,1 (2008): 89-97.
Franklin JL, Keeton AB, Bortoff KD, Messina JL. Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells. Int J Clin Exp Med. 2008;1(1):89-97. Epub 2008 Jan 25. PMID: 19079690; PMCID: PMC2596339.
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IFN signaling: how a non-canonical model led to the development of IFN mimetics.

Frontiers in immunology

Johnson HM, Noon-Song EN, Dabelic R, Ahmed CM.
PMID: 23898330
Front Immunol. 2013 Jul 25;4:202. doi: 10.3389/fimmu.2013.00202. eCollection 2013.

The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin,...

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Johnson HM, Noon-Song EN, Dabelic R, et al. IFN signaling: how a non-canonical model led to the development of IFN mimetics. Front Immunol. 2013;4:202doi: 10.3389/fimmu.2013.00202.
Johnson, H. M., Noon-Song, E. N., Dabelic, R., & Ahmed, C. M. (2013). IFN signaling: how a non-canonical model led to the development of IFN mimetics. Frontiers in immunology, 4202. https://doi.org/10.3389/fimmu.2013.00202
Johnson, Howard M, et al. "IFN signaling: how a non-canonical model led to the development of IFN mimetics." Frontiers in immunology vol. 4 (2013): 202. doi: https://doi.org/10.3389/fimmu.2013.00202
Johnson HM, Noon-Song EN, Dabelic R, Ahmed CM. IFN signaling: how a non-canonical model led to the development of IFN mimetics. Front Immunol. 2013 Jul 25;4:202. doi: 10.3389/fimmu.2013.00202. eCollection 2013. PMID: 23898330; PMCID: PMC3722551.
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Showing 13 to 24 of 37 entries