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Showing 7549 to 7558 of 7558 entries
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PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.

Frontiers in endocrinology

Hayata-Takano A, Shintani Y, Moriguchi K, Encho N, Kitagawa K, Nakazawa T, Hashimoto H.
PMID: 34759890
Front Endocrinol (Lausanne). 2021 Oct 25;12:732456. doi: 10.3389/fendo.2021.732456. eCollection 2021.

Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT

Polymorphisms of the Serotonin Transporter Gene and G-Protein β3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia.

Gut and liver

Park CS, Uhm JH.
PMID: 22570752
Gut Liver. 2012 Apr;6(2):223-8. doi: 10.5009/gnl.2012.6.2.223. Epub 2012 Apr 17.

BACKGROUND/AIMS: Many candidate gene studies have revealed that polymorphisms of the 5'-flanking controlled SERT gene linked polymorphic region (5HTT-LPR) gene and G-protein β3 C825T gene might be associated with functional dyspepsia (FD) and irritable bowel syndrome (IBS). This study...

Overcoming Depression with 5-HT.

International journal of molecular sciences

Zięba A, Stępnicki P, Matosiuk D, Kaczor AA.
PMID: 35008436
Int J Mol Sci. 2021 Dec 21;23(1). doi: 10.3390/ijms23010010.

Depression is a multifactorial disorder that affects millions of people worldwide, and none of the currently available therapeutics can completely cure it. Thus, there is a need for developing novel, potent, and safer agents. Recent medicinal chemistry findings on...

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer's Disease.

Frontiers in pharmacology

Caruso G, Grasso M, Fidilio A, Torrisi SA, Musso N, Geraci F, Tropea MR, Privitera A, Tascedda F, Puzzo D, Salomone S, Drago F, Leggio GM, Caraci F.
PMID: 35002742
Front Pharmacol. 2021 Dec 24;12:809541. doi: 10.3389/fphar.2021.809541. eCollection 2021.

Depression is a risk factor for the development of Alzheimer's disease (AD). A neurobiological and clinical continuum exists between AD and depression, with neuroinflammation and oxidative stress being involved in both diseases. Second-generation antidepressants, in particular selective serotonin reuptake...

Alcohol, Aggression, and Violence: From Public Health to Neuroscience.

Frontiers in psychology

Sontate KV, Rahim Kamaluddin M, Naina Mohamed I, Mohamed RMP, Shaikh MF, Kamal H, Kumar J.
PMID: 35002823
Front Psychol. 2021 Dec 20;12:699726. doi: 10.3389/fpsyg.2021.699726. eCollection 2021.

Alcohol has been associated with violent crimes and domestic violence across many nations. Various etiological factors were linked to chronic alcohol use and violence including psychiatric comorbidities of perpetrators such as personality disorders, mood disorders, and intermittent explosive disorders....

Serotonin system genes contribute to the susceptibility to obesity in Black adolescents.

Obesity science & practice

Meng Y, Groth SW, Hodgkinson CA, Mariani TJ.
PMID: 34401202
Obes Sci Pract. 2021 Mar 27;7(4):441-449. doi: 10.1002/osp4.511. eCollection 2021 Aug.

OBJECTIVE: The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose...

Association of Low-Dose Quetiapine and Diabetes.

JAMA network open

Højlund M, Lund LC, Andersen K, Correll CU, Hallas J.
PMID: 33961038
JAMA Netw Open. 2021 May 03;4(5):e213209. doi: 10.1001/jamanetworkopen.2021.3209.

IMPORTANCE: Quetiapine has been associated with increased risk of type 2 diabetes when used in medium or high doses for the treatment of severe mental disorders. It is not known whether low doses, commonly used off-label for sedative-hypnotic purposes,...

Effects of prokinetics on the digestive tract.

Current reviews in clinical and experimental pharmacology

Usai-Satta P, Lai M, Oppia F, Cabras F.
PMID: 34455950
Curr Rev Clin Exp Pharmacol. 2021 Aug 05; doi: 10.2174/2772432816666210805125813. Epub 2021 Aug 05.

BACKGROUND: Functional gastrointestinal disorders account for at least a third of visits to gastroenterology clinics. Despite pathophysiological complexity, an impaired gut motility may be frequently present in these disorders.INTRODUCTION: Prokinetics are a class of drugs that promote gastrointestinal motility,...

Haloperidol augmentation of fluvoxamine in skin picking disorder: a case report.

Journal of medical case reports

Luca M, Vecchio C, Luca A, Calandra C.
PMID: 22834980
J Med Case Rep. 2012 Jul 26;6:219. doi: 10.1186/1752-1947-6-219.

INTRODUCTION: Compulsive skin picking, being part of the broader category of impulse control disorders, is considered a residual diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. It is characterized by excessive scratching or...

Hiccups in an Adult Case with Schizophrenia due to Aripiprazole: A Case Report.

Noro psikiyatri arsivi

Kutuk MO, Berdzenishvili E, Aksu GG.
PMID: 33795958
Noro Psikiyatr Ars. 2021 Jan 16;58(1):77-78. doi: 10.29399/npa.27152. eCollection 2021 Mar.

Neurotransmitters and neuroreceptors involved in the pathophysiology of hiccups are not well defined. However, dopamine and serotonin are reported to have roles in activating hiccups, and recent case reports suggest that some psychopharmacologic medications -such as antipsychotics- may trigger...

Showing 7549 to 7558 of 7558 entries