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Showing 13 to 24 of 36 entries
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Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts.

Frontiers in physiology

Russo I, Femminò S, Barale C, Tullio F, Geuna S, Cavalot F, Pagliaro P, Penna C.
PMID: 30042694
Front Physiol. 2018 Jul 10;9:875. doi: 10.3389/fphys.2018.00875. eCollection 2018.

Platelets affect myocardial damage from ischemia/reperfusion. Redox-dependent sphingosine-1-phosphate production and release are altered in diabetic platelets. Sphingosine-1-phosphate is a double-edged sword for ischemia/reperfusion injury. Therefore, we aimed to verify whether: (1) human healthy- or diabetic-platelets are cardioprotective, (2) sphingosine-1-phosphate...

An Update for Pharmacologists on New Treatment Options for Inflammatory Bowel Disease: The Clinicians' Perspective.

Frontiers in pharmacology

Schmidt C, Grunert PC, Stallmach A.
PMID: 33912062
Front Pharmacol. 2021 Apr 12;12:655054. doi: 10.3389/fphar.2021.655054. eCollection 2021.

The introduction of anti-tumor necrosis factor antibodies resulted in a considerable expansion of the options available for the treatment of inflammatory bowel disease. Unfortunately, approximately one third of treated patients do not respond to these modalities, and drug efficacy...

Blood-thirsty: S1PR5 and TRM.

The Journal of experimental medicine

Hallisey VM, Schwab SR.
PMID: 34714328
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20211971. Epub 2021 Oct 29.

In this elegant study, Evrard et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210116) find that sphingosine 1-phosphate receptor 5 (S1PR5) powerfully impairs tissue-resident memory T cell (TRM) formation, and that tissue-derived TGF-β limits S1pr5 expression by infiltrating T cells.

Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome.

Cellular and molecular gastroenterology and hepatology

Hong CH, Ko MS, Kim JH, Cho H, Lee CH, Yoon JE, Yun JY, Baek IJ, Jang JE, Lee SE, Cho YK, Baek JY, Oh SJ, Lee BY, Lim JS, Lee J, Hartig SM, Conde de la Rosa L, Garcia-Ruiz C, Lee KU, Fernández-Checa JC, Choi JW, Kim S, Koh EH.
PMID: 34890841
Cell Mol Gastroenterol Hepatol. 2021 Dec 07; doi: 10.1016/j.jcmgh.2021.12.002. Epub 2021 Dec 07.

BACKGROUND & AIMS: Sphingosine 1-phosphate receptors (S1PRs) are a group of G protein-coupled receptors that confer a broad range of functional effects in chronic inflammatory and metabolic diseases. S1PRs may also mediate the development of non-alcoholic steatohepatitis (NASH), but...

Role of sphingosine-1-phosphate mediated signalling in systemic lupus erythematosus.

Prostaglandins & other lipid mediators

Tian J, Huang T, Chang S, Wang Y, Fan W, Ji H, Wang J, Yang J, Kang J, Zhou Y.
PMID: 34352381
Prostaglandins Other Lipid Mediat. 2021 Oct;156:106584. doi: 10.1016/j.prostaglandins.2021.106584. Epub 2021 Aug 02.

Systemic lupus erythematosus (SLE) is a highly prevalent autoimmune disease characterized by the malfunction of the immune system and the persistent presence of an inflammatory environment. Multiple organs can be affected during SLE, leading to heterogeneous manifestations, which eventually...

Signaling through the S1P-S1PR Axis in the Gut, the Immune and the Central Nervous System in Multiple Sclerosis: Implication for Pathogenesis and Treatment.

Cells

Chatzikonstantinou S, Poulidou V, Arnaoutoglou M, Kazis D, Heliopoulos I, Grigoriadis N, Boziki M.
PMID: 34831439
Cells. 2021 Nov 18;10(11). doi: 10.3390/cells10113217.

Sphingosine 1-phosphate (S1P) is a signaling molecule with complex biological functions that are exerted through the activation of sphingosine 1-phosphate receptors 1-5 (S1PR1-5). S1PR expression is necessary for cell proliferation, angiogenesis, neurogenesis and, importantly, for the egress of lymphocytes...

Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling Gαi/Gαs Conversion.

Frontiers in pharmacology

Wang RH, Dai XJ, Wu H, Wang MD, Deng R, Wang Y, Bu YH, Sun MH, Zhang H.
PMID: 33363467
Front Pharmacol. 2020 Dec 08;11:584176. doi: 10.3389/fphar.2020.584176. eCollection 2020.

The activated Gα protein subunit (Gαs) and the inhibitory Gα protein subunit (Gαi) are involved in the signal transduction of G protein coupled receptors (GPCRs). Moreover, the conversion of Gαi/Gαs can couple with sphingosine-1-phosphate receptors (S1PRs) and have a...

Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.

Cellular and molecular gastroenterology and hepatology

Hwan Hong C, Ko MS, Kim JH, Cho H, Lee CH, Yoon JE, Yun JY, Baek IJ, Jang JE, Lee SE, Cho YK, Baek JY, Oh SJ, Lee BY, Lim JS, Lee J, Hartig SM, Conde de la Rosa L, Garcia-Ruiz C, Lee KU, Fernández-Checa JC, Choi JW, Kim S, Koh EH.
PMID: 34890841
Cell Mol Gastroenterol Hepatol. 2021 Dec 08; doi: 10.1016/j.jcmgh.2021.12.002. Epub 2021 Dec 08.

BACKGROUND & AIMS: Sphingosine 1-phosphate receptors (S1PRs) are a group of G-protein-coupled receptors that confer a broad range of functional effects in chronic inflammatory and metabolic diseases. S1PRs also may mediate the development of nonalcoholic steatohepatitis (NASH), but the...

Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5.

The Journal of pharmacology and experimental therapeutics

Selkirk JV, Dines KC, Yan YG, Ching N, Dalvie D, Biswas S, Bortolato A, Schkeryantz JM, Lopez C, Ruiz I, Hargreaves R.
PMID: 34535564
J Pharmacol Exp Ther. 2021 Dec;379(3):386-399. doi: 10.1124/jpet.121.000741. Epub 2021 Sep 17.

Ozanimod, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.

Oncogenesis

Hait NC, Avni D, Yamada A, Nagahashi M, Aoyagi T, Aoki H, Dumur CI, Zelenko Z, Gallagher EJ, Leroith D, Milstien S, Takabe K, Spiegel S.
PMID: 26053034
Oncogenesis. 2015 Jun 08;4:e156. doi: 10.1038/oncsis.2015.16.

Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and does not respond to conventional hormonal therapies. Strategies that lead to re-expression of ERα could sensitize ERα-negative breast cancers to selective ER modulators. FTY720 (fingolimod, Gilenya), a sphingosine analog, is...

Long noncoding RNAs APOA1-AS, IFNG-AS1, RMRP and their related biomolecules in Egyptian patients with relapsing-remitting multiple sclerosis: Relation to disease activity and patient disability.

Journal of advanced research

Ghaiad HR, Elmazny AN, Nooh MM, El-Sawalhi MM, Shaheen AA.
PMID: 32071782
J Adv Res. 2019 Nov 04;21:141-150. doi: 10.1016/j.jare.2019.10.012. eCollection 2020 Jan.

Lately, long noncoding (lnc) RNAs are increasingly appreciated for their involvement in multiple sclerosis (MS). In inflammation and autoimmunity, a role of apoprotein A1 (ApoA1), mediated by sphingosine 1-phosphate receptors (S1PRs), was reported. However, the epigenetic mechanisms regulating these...

Characterization and Expression of Sphingosine 1-Phosphate Receptors in Human and Rat Heart.

Frontiers in pharmacology

Ahmed N, Linardi D, Decimo I, Mehboob R, Gebrie MA, Innamorati G, Luciani GB, Faggian G, Rungatscher A.
PMID: 28596734
Front Pharmacol. 2017 May 24;8:312. doi: 10.3389/fphar.2017.00312. eCollection 2017.

No abstract available.

Showing 13 to 24 of 36 entries