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Showing 25 to 36 of 963 entries
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Isolation and characterization of muscle fatigue substance with anti-tumor activities.

Journal of Cancer

Munoz RM, Han H, Tegeler T, Petritis K, Von Hoff DD, Hoffman SA.
PMID: 23678371
J Cancer. 2013 May 09;4(4):343-9. doi: 10.7150/jca.5418. Print 2013.

Research during the 1950's indicated that exercise played a role in the reduction of tumor growth. In the 1960's our studies confirmed that tumor-bearing rats, exercised to fatigue, demonstrated tumor inhibition. Our further studies isolated an extract (Fatigue Substance,...

The therapeutic use of analgesics in patients with liver cirrhosis: a literature review and evidence-based recommendations.

Hepatitis monthly

Imani F, Motavaf M, Safari S, Alavian SM.
PMID: 25477978
Hepat Mon. 2014 Oct 11;14(10):e23539. doi: 10.5812/hepatmon.23539. eCollection 2014 Oct.

CONTEXT: Pain management in cirrhotic patients is a major clinical challenge for medical professionals. Unfortunately there are no concrete guidelines available regarding the administration of analgesics in patients with liver cirrhosis. In this review we aimed to summarize the...

Quantification and immunocytochemical characteristics of trigeminal ganglion neurons projecting to the cornea: effect of corneal wounding.

European journal of pain (London, England)

Felipe CD, Gonzalez GG, Gallar J, Belmonte C.
PMID: 10700335
Eur J Pain. 1999 Mar;3(1):31-39. doi: 10.1053/eujp.1998.0100.

The number and immunocytochemical characteristics of trigeminal ganglion neurons providing sensory innervation to the cornea were studied in the mouse. Corneal neurons were retrogradely labelled with fluorogold placed on the cornea after removal of the epithelium with n-heptanol. Corneal...

FEBS letters

Zühlke H, Kohnert K, Ziegler M, Knospe S, Behlke J.
PMID: 11945797
FEBS Lett. 1971 May 20;14(5):357-359. doi: 10.1016/0014-5793(71)80300-9.

A component with high molecular weight is prepared from commercial bovine insulin by gel filtration on Sephadex G 50. The substance has little biological and immunological activity in comparison to insulin. The activity is not changed by incubation with...

Effects of Putative Neurotransmitters of the Carotid Body on its Own Glomus Cells.

The European journal of neuroscience

Eyzaguirre C, Monti-Bloch L, Woodbury JW.
PMID: 12106105
Eur J Neurosci. 1990 Jan;2(1):77-88. doi: 10.1111/j.1460-9568.1990.tb00383.x.

Carotid body glomus cells produce and release acetylcholine (ACh), catecholamines, and neuropeptides, and there is biochemical evidence that these cells possess receptors for these substances. Thus, we studied the effects of cholinergics [ACh, nicotine (Nic), bethanechol (BN)] and peptides...

Baclofen and the Release of Neuropeptides in the Cat Spinal Cord.

The European journal of neuroscience

Morton CR, Hutchison WD, Lacey G.
PMID: 12106370
Eur J Neurosci. 1992;4(3):243-250. doi: 10.1111/j.1460-9568.1992.tb00872.x.

The antibody microprobe technique was used to study the effect of baclofen on the release of immunoreactive substance P and immunoreactive calcitonin gene-related peptide within the lower lumbar spinal cord of pentobarbitone-anaesthetized spinalized cats. Both peptides were released in...

Gonadotropin - releasing hormone (GnRH) content in the medial basal hypothalamus after substance P injection into the 3rd cerebral ventricle in female rats.

Endocrine regulations

Walczewska A, Dziedzic B, Jakubowska-Naziemblo B, Traczyk WZ.
PMID: 10979041
Endocr Regul. 1996 Jun;30(2):99-107.

The effect of substance P (SP) on gonadotropin releasing hormone (GnRH) content in the medial basal hypothalamus (MBH) was studied. To evaluate this effect, 5 microg of SP in saline or saline alone were injected into the 3rd cerebral...

Calcitonin Gene-related Peptide Causes Intraspinal Spreading of Substance P Released by Peripheral Stimulation.

The European journal of neuroscience

Schaible HG, Hope PJ, Lang CW, Duggan AW.
PMID: 12106319
Eur J Neurosci. 1992;4(8):750-7. doi: 10.1111/j.1460-9568.1992.tb00184.x.

Experiments were performed in barbiturate-anaesthetized, spinalized cats to investigate the effect of calcitonin gene-related peptide (CGRP) on the spatial distribution of immunoreactive substance P (ir-SP) in the spinal cord released by electrical nerve stimulation and noxious mechanical stimuli. The...

Monoaminergic and Peptidergic Innervation of the Intermedio-Lateral Horn of the Spinal Cord.

The European journal of neuroscience

Fuxe K, Tinner B, Bjelke B, Agnati LF, Verhofstad A, Steinbusch HG, Goldstein M, Kalia M.
PMID: 12106030
Eur J Neurosci. 1990;2(5):430-450. doi: 10.1111/j.1460-9568.1990.tb00435.x.

In the rat the monoaminergic and neuropeptidergic innervation of the sympathetic visceral nuclei of the entire thoracic spinal cord has been analysed in serial horizontal sections using immunocytochemistry. Tyrosine hydroxylase (TH), Phenyl-ethanolamine-N-methyl-transferase (PNMT), 5-hydroxytryptamine (5-HT), substance P (SP) and...

Bronchial responses to substance P after antigen challenge in the guinea-pig: in vivo and in vitro studies.

Mediators of inflammation

Boichot E, Lagente V, Gall GL, Carré C, Mencia-Huerta JM, Braquet P, Lockhart A, Frossard N.
PMID: 18475463
Mediators Inflamm. 1992;1(3):207-12. doi: 10.1155/S0962935192000322.

The effect of antigen challenge on the airway responses to substance P and on the epithelial neutral endopeptidase (NEP) activity was investigated in aerosol sensitized guinea-pigs. In vivo, bronchial responses to aerosolized substance P were similar to the responses...

Neurogenic inflammation in lung disease: burnt out?.

Inflammopharmacology

Rogers DF.
PMID: 17657611
Inflammopharmacology. 1997;5(4):319-29. doi: 10.1007/s10787-997-0029-2.

Neurogenic inflammation results from activation of sensory nerves which, acting in an 'efferent' manner, release sensory neuropeptides to induce a wide variety of physiological and immunological responses. This process is easy to demonstrate experimentally in the airways of small...

[Nerve distribution in synovium of osteoarthritic knees].

Clinical calcium

Saito T, Koshino T.
PMID: 15775277
Clin Calcium. 2002 Jan;12(1):59-62. doi: CliCa02015962.

Neural elements are widely distributed in synovium of osteoarthritic knees. In medial compartmental osteoarthritic knees, medial synovium is exposed to mechanical stimuli due to osteophytes and lateral thrust, which may accumulate neuropeptides, especially substance P, in free nerve endings....

Showing 25 to 36 of 963 entries