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Showing 25 to 36 of 383 entries
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Methotrexate: optimizing the efficacy in rheumatoid arthritis.

Therapeutic advances in musculoskeletal disease

Braun J.
PMID: 22870474
Ther Adv Musculoskelet Dis. 2011 Jun;3(3):151-8. doi: 10.1177/1759720X11408635.

Methotrexate (MTX) is currently the most frequently used drugs in the treatment of rheumatoid arthritis (RA). The drug had been synthesized in 1948 and first tests to treat patients with psoriasis and RA were published in 1951. However, until...

Cilostazol against 2,4,6-trinitrobenzene sulfonic acid-induced colitis: Effect on tight junction, inflammation, and apoptosis.

JGH open : an open access journal of gastroenterology and hepatology

Al-Kishali HA, Abd El Fattah MA, Mohammad WA, El-Abhar HS.
PMID: 31406920
JGH Open. 2019 Mar 29;3(4):281-289. doi: 10.1002/jgh3.12148. eCollection 2019 Aug.

BACKGROUND: Inflammatory bowel diseases are immunologically mediated disorders of gastrointestinal tract, characterized by dysregulated immune responses that result in a chronic intestinal inflammation. The antiplatelet cilostazol (CS), a phosphodiesterase-III inhibitor, exerted a beneficial effect on several models of gastrointestinal...

Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats.

Inflammopharmacology

Tekeli İO, Ateşşahin A, Sakin F, Aslan A, Çeribaşı S, Yipel M.
PMID: 29736689
Inflammopharmacology. 2018 May 07; doi: 10.1007/s10787-018-0485-x. Epub 2018 May 07.

OBJECTIVE: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.METHODS: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo...

Etanercept in the treatment of ankylosing spondylitis: A systematic review and meta-analysis.

Experimental and therapeutic medicine

Liu YF, Dong H, Tu SH, Zheng CH, Liu PL, Hu YH.
PMID: 25289064
Exp Ther Med. 2014 Nov;8(5):1585-1592. doi: 10.3892/etm.2014.1974. Epub 2014 Sep 17.

Etanercept (ETN) has been widely applied in the treatment of ankylosing spondylitis (AS). As the use of ETN has increased, associated adverse effects have been reported frequently. Previous meta-analyses have focused on comparing the differences in clinical outcomes between...

Probiotic Medilac-S.

World journal of clinical cases

Sohail G, Xu X, Christman MC, Tompkins TA.
PMID: 30568952
World J Clin Cases. 2018 Dec 06;6(15):961-984. doi: 10.12998/wjcc.v6.i15.961.

AIM: To assess the effects of probiotic Medilac-SMETHODS: A systematic literature search was conducted to find randomized, controlled trials in a Chinese population with at least two study arms - a control arm which receives a conventional, oral aminosalicylate...

Sulfasalazine-induced renal and hepatic injury in rats and the protective role of taurine.

BioImpacts : BI

Heidari R, Rasti M, Shirazi Yeganeh B, Niknahad H, Saeedi A, Najibi A.
PMID: 27340618
Bioimpacts. 2016;6(1):3-8. doi: 10.15171/bi.2016.01. Epub 2016 Mar 28.

INTRODUCTION: Sulfasalazine is a drug commonly administrated against inflammatory-based disorders. On the other hand, kidney and liver injury are serious adverse events accompanied by sulfasalazine administration. No specific therapeutic option is available against this complication. The current investigation was...

Gut microbiota-driven drug metabolism in inflammatory bowel disease.

Journal of Crohn's & colitis

Crouwel F, Buiter HJC, de Boer NK.
PMID: 32652007
J Crohns Colitis. 2020 Jul 11; doi: 10.1093/ecco-jcc/jjaa143. Epub 2020 Jul 11.

BACKGROUND AND AIMS: The gut microbiota plays an important role in the metabolization and modulation of several types of drugs. With this study we aimed to review the literature about microbial drug metabolism of medication prescribed in inflammatory bowel...

Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis: Republished.

Inflammatory bowel diseases

Coward S, Kuenzig ME, Hazlewood G, Clement F, McBrien K, Holmes R, Panaccione R, Ghosh S, Seow CH, Rezaie A, Kaplan GG.
PMID: 30052985
Inflamm Bowel Dis. 2017 May 01;23(5):E26-E37. doi: 10.1097/MIB.0000000000001158.

BACKGROUND: Induction treatment of mild-to-moderate Crohn's disease is controversial.PURPOSE: To compare the induction of remission between different doses of mesalamine, sulfasalazine, corticosteroids, and budesonide for active Crohn's disease.DATA SOURCES: We identified randomized controlled trials from existing Cochrane reviews and...

Letter by Lu et al. regarding article, "Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia".

Hypertension in pregnancy

Deng Z, Lu D.
PMID: 34978249
Hypertens Pregnancy. 2022 Jan 02;1-2. doi: 10.1080/10641955.2021.2024224. Epub 2022 Jan 02.

No abstract available.

Erratum: Sulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Corrigendum].

Drug design, development and therapy

[No authors listed]
PMID: 34163142
Drug Des Devel Ther. 2021 Jun 16;15:2563. doi: 10.2147/DDDT.S324356. eCollection 2021.

[This corrects the article DOI: 10.2147/DDDT.S107679.].

Joint Estimation of Remission and Response for Methotrexate-Based DMARD Options in Rheumatoid Arthritis: A Bivariate Network Meta-Analysis.

ACR open rheumatology

Pokharel G, Deardon R, Barnabe C, Bykerk V, Bartlett SJ, Bessette L, Boire G, Hitchon CA, Keystone E, Pope J, Schieir O, Tin D, Thorne C, Hazlewood GS.
PMID: 31777827
ACR Open Rheumatol. 2019 Aug 08;1(8):471-479. doi: 10.1002/acr2.11052. eCollection 2019 Oct.

OBJECTIVE: To jointly estimate American College of Rheumatology (ACR50) response (a more commonly reported outcome) and remission (a more clinically relevant outcome) for methotrexate (MTX)-based treatment options in rheumatoid arthritis (RA).METHODS: We conducted a bivariate network meta-analysis (NMA) to...

Protective and Therapeutic Effects of Aloe Vera Gel on Ulcerative Colitis Induced by Acetic Acid in Rats.

Clinical nutrition research

Bahrami G, Malekshahi H, Miraghaee S, Madani H, Babaei A, Mohammadi B, Hatami R.
PMID: 32789152
Clin Nutr Res. 2020 Jul 30;9(3):223-234. doi: 10.7762/cnr.2020.9.3.223. eCollection 2020 Jul.

Ulcerative colitis (UC) is a chronic intestinal inflammation. Common clinical symptoms are weight loss, diarrhea, ulcers, and inflammation. Aloe vera (AV) has several medicinal properties including antioxidant, anti-inflammatory analgesic, and improvement of gastric and skin ulcers. This study aimed...

Showing 25 to 36 of 383 entries