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The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity.

Heliyon

Ngo Hanna J, Nziko VPN, Ntie-Kang F, Mbah JA, Toze FAA.
PMID: 34095565
Heliyon. 2021 May 21;7(5):e07032. doi: 10.1016/j.heliyon.2021.e07032. eCollection 2021 May.

A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven

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Ngo Hanna J, Nziko VPN, Ntie-Kang F, et al. The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity. Heliyon. 2021;7(5):e07032doi: 10.1016/j.heliyon.2021.e07032.
Ngo Hanna, J., Nziko, V. P. N., Ntie-Kang, F., Mbah, J. A., & Toze, F. A. A. (2021). The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity. Heliyon, 7(5), e07032. https://doi.org/10.1016/j.heliyon.2021.e07032
Ngo Hanna, Joelleinsert, et al. "The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity." Heliyon vol. 7,5 (2021): e07032. doi: https://doi.org/10.1016/j.heliyon.2021.e07032
Ngo Hanna J, Nziko VPN, Ntie-Kang F, Mbah JA, Toze FAA. The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity. Heliyon. 2021 May 21;7(5):e07032. doi: 10.1016/j.heliyon.2021.e07032. eCollection 2021 May. PMID: 34095565; PMCID: PMC8165424.
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Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines.

ACS catalysis

Kim AN, Ngamnithiporn A, Welin ER, Daiger MT, Grünanger CU, Bartberger MD, Virgil SC, Stoltz BM.
PMID: 34046244
ACS Catal. 2020 Mar 06;10(5):3241-3248. doi: 10.1021/acscatal.0c00211. Epub 2020 Feb 10.

The development of a general method utilizing a hydroxymethyl directing group for asymmetric hydrogenation of 1,3-disubstituted isoquinolines to provide chiral 1,2,3,4-tetrahydroisoquinolines is reported. The reaction, which utilizes [Ir(cod)Cl]

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Kim AN, Ngamnithiporn A, Welin ER, et al. Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines. ACS Catal. 2020;10(5):3241-3248doi: 10.1021/acscatal.0c00211.
Kim, A. N., Ngamnithiporn, A., Welin, E. R., Daiger, M. T., Grünanger, C. U., Bartberger, M. D., Virgil, S. C., & Stoltz, B. M. (2020). Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines. ACS catalysis, 10(5), 3241-3248. https://doi.org/10.1021/acscatal.0c00211
Kim, Alexia N, et al. "Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines." ACS catalysis vol. 10,5 (2020): 3241-3248. doi: https://doi.org/10.1021/acscatal.0c00211
Kim AN, Ngamnithiporn A, Welin ER, Daiger MT, Grünanger CU, Bartberger MD, Virgil SC, Stoltz BM. Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines. ACS Catal. 2020 Mar 06;10(5):3241-3248. doi: 10.1021/acscatal.0c00211. Epub 2020 Feb 10. PMID: 34046244; PMCID: PMC8152574.
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Cross-dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines Catalyzed by an Anthraquinone-containing Polymeric Photosensitizer.

Chemistry, an Asian journal

Wang F, Yu D, Chen Y, Sun J, Wang JY, Zhou MD.
PMID: 34668333
Chem Asian J. 2021 Oct 20; doi: 10.1002/asia.202100978. Epub 2021 Oct 20.

This work reports the photocatalytic application of an anthraquinone-containing polymeric photosensitizer (AQ-PHEMA) in the visible light-induced cross-dehydrogenative-coupling of N-aryl tetrahydroisoquinolines with several nucleophiles, including nitromethane, 1-methyl-2-alkyl ketone and dialkyl (aryl) phosphine oxide. The results revealed that the reaction could...

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Wang F, Yu D, Chen Y, et al. Cross-dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines Catalyzed by an Anthraquinone-containing Polymeric Photosensitizer. Chem Asian J. 2021;doi: 10.1002/asia.202100978.
Wang, F., Yu, D., Chen, Y., Sun, J., Wang, J. Y., & Zhou, M. D. (2021). Cross-dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines Catalyzed by an Anthraquinone-containing Polymeric Photosensitizer. Chemistry, an Asian journal, . https://doi.org/10.1002/asia.202100978
Wang, Fei, et al. "Cross-dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines Catalyzed by an Anthraquinone-containing Polymeric Photosensitizer." Chemistry, an Asian journal vol. (2021). doi: https://doi.org/10.1002/asia.202100978
Wang F, Yu D, Chen Y, Sun J, Wang JY, Zhou MD. Cross-dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines Catalyzed by an Anthraquinone-containing Polymeric Photosensitizer. Chem Asian J. 2021 Oct 20; doi: 10.1002/asia.202100978. Epub 2021 Oct 20. PMID: 34668333.
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Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp.

Chemical communications (Cambridge, England)

Xia Y, Wade NW, Palermo PN, Wang Y, Wang YM.
PMID: 34816837
Chem Commun (Camb). 2021 Dec 09;57(98):13329-13332. doi: 10.1039/d1cc05949a.

An iron-catalysed C-H functionalisation of simple monosubstituted allenes for the synthesis of 1-tetrahydroisoquinolinyl 1,1-disubstituted allenes is reported. This transformation represents the first example of a direct conversion of allenic C-H bonds to C-C bonds through cross dehydrogenative coupling. The...

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Xia Y, Wade NW, Palermo PN, et al. Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp. Chem Commun (Camb). 2021;57(98):13329-13332doi: 10.1039/d1cc05949a.
Xia, Y., Wade, N. W., Palermo, P. N., Wang, Y., & Wang, Y. M. (2021). Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp. Chemical communications (Cambridge, England), 57(98), 13329-13332. https://doi.org/10.1039/d1cc05949a
Xia, Yue, et al. "Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp." Chemical communications (Cambridge, England) vol. 57,98 (2021): 13329-13332. doi: https://doi.org/10.1039/d1cc05949a
Xia Y, Wade NW, Palermo PN, Wang Y, Wang YM. Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp. Chem Commun (Camb). 2021 Dec 09;57(98):13329-13332. doi: 10.1039/d1cc05949a. PMID: 34816837; PMCID: PMC8665127.
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Showing 157 to 160 of 160 entries