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Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods.

Toxicology and applied pharmacology

Sim KS, Park S, Seo H, Lee SH, Lee HS, Park Y, Kim JH.
PMID: 34848279
Toxicol Appl Pharmacol. 2021 Nov 27;434:115815. doi: 10.1016/j.taap.2021.115815. Epub 2021 Nov 27.

With growing scientific interest in phytoestrogens, a number of studies have investigated the estrogenic potential of phytoestrogens in a wide variety of assay systems. However, evaluations of individual phytoestrogens with different assay systems make it difficult for predicting their...

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Sim KS, Park S, Seo H, et al. Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods. Toxicol Appl Pharmacol. 2021;434:115815doi: 10.1016/j.taap.2021.115815.
Sim, K. S., Park, S., Seo, H., Lee, S. H., Lee, H. S., Park, Y., & Kim, J. H. (2021). Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods. Toxicology and applied pharmacology, 434115815. https://doi.org/10.1016/j.taap.2021.115815
Sim, Kyu Sang, et al. "Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods." Toxicology and applied pharmacology vol. 434 (2021): 115815. doi: https://doi.org/10.1016/j.taap.2021.115815
Sim KS, Park S, Seo H, Lee SH, Lee HS, Park Y, Kim JH. Comparative study of estrogenic activities of phytoestrogens using OECD in vitro and in vivo testing methods. Toxicol Appl Pharmacol. 2021 Nov 27;434:115815. doi: 10.1016/j.taap.2021.115815. Epub 2021 Nov 27. PMID: 34848279.
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Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo.

Toxicology and applied pharmacology

Song C, Li D, Zhang J, Zhao X.
PMID: 34973290
Toxicol Appl Pharmacol. 2022 Jan 15;435:115852. doi: 10.1016/j.taap.2021.115852. Epub 2021 Dec 29.

Imatinib Mesylate (IMA) has been widely used to treat with chronic myeloid leukemia (CML). However, cardiotoxicity associated with IMA is included among the therapeutic strategies. The present study was aimed to discover whether ferroptosis, a programmed iron-dependent cell death,...

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Song C, Li D, Zhang J, et al. Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo. Toxicol Appl Pharmacol. 2021;435:115852doi: 10.1016/j.taap.2021.115852.
Song, C., Li, D., Zhang, J., & Zhao, X. (2022). Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo. Toxicology and applied pharmacology, 435115852. https://doi.org/10.1016/j.taap.2021.115852
Song, Chengzhu, et al. "Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo." Toxicology and applied pharmacology vol. 435 (2022): 115852. doi: https://doi.org/10.1016/j.taap.2021.115852
Song C, Li D, Zhang J, Zhao X. Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo. Toxicol Appl Pharmacol. 2022 Jan 15;435:115852. doi: 10.1016/j.taap.2021.115852. Epub 2021 Dec 29. PMID: 34973290.
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A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports.

Toxicology and applied pharmacology

Samarghandian S, Shirazi FM, Saeedi F, Roshanravan B, Pourbagher-Shahri AM, Khorasani EY, Farkhondeh T, Aaseth JO, Abdollahi M, Mehrpour O.
PMID: 34416225
Toxicol Appl Pharmacol. 2021 Oct 15;429:115681. doi: 10.1016/j.taap.2021.115681. Epub 2021 Aug 18.

Lead is one of the most toxic heavy metals in the environment. The present review aimed to highlight hazardous pollution sources, management, and review symptoms of lead poisonings in various parts of the world. The present study summarized the...

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Samarghandian S, Shirazi FM, Saeedi F, et al. A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports. Toxicol Appl Pharmacol. 2021;429:115681doi: 10.1016/j.taap.2021.115681.
Samarghandian, S., Shirazi, F. M., Saeedi, F., Roshanravan, B., Pourbagher-Shahri, A. M., Khorasani, E. Y., Farkhondeh, T., Aaseth, J. O., Abdollahi, M., & Mehrpour, O. (2021). A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports. Toxicology and applied pharmacology, 429115681. https://doi.org/10.1016/j.taap.2021.115681
Samarghandian, Saeed, et al. "A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports." Toxicology and applied pharmacology vol. 429 (2021): 115681. doi: https://doi.org/10.1016/j.taap.2021.115681
Samarghandian S, Shirazi FM, Saeedi F, Roshanravan B, Pourbagher-Shahri AM, Khorasani EY, Farkhondeh T, Aaseth JO, Abdollahi M, Mehrpour O. A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports. Toxicol Appl Pharmacol. 2021 Oct 15;429:115681. doi: 10.1016/j.taap.2021.115681. Epub 2021 Aug 18. PMID: 34416225.
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Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat.

Toxicology and applied pharmacology

Schyman P, Printz RL, Pannala VR, AbdulHameed MDM, Estes SK, Shiota C, Boyd KL, Shiota M, Wallqvist A.
PMID: 34492290
Toxicol Appl Pharmacol. 2021 Nov 01;430:115713. doi: 10.1016/j.taap.2021.115713. Epub 2021 Sep 04.

To study the complex processes involved in liver injuries, researchers rely on animal investigations, using chemically or surgically induced liver injuries, to extrapolate findings and infer human health risks. However, this presents obvious challenges in performing a detailed comparison...

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Schyman P, Printz RL, Pannala VR, et al. Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat. Toxicol Appl Pharmacol. 2021;430:115713doi: 10.1016/j.taap.2021.115713.
Schyman, P., Printz, R. L., Pannala, V. R., AbdulHameed, M. D. M., Estes, S. K., Shiota, C., Boyd, K. L., Shiota, M., & Wallqvist, A. (2021). Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat. Toxicology and applied pharmacology, 430115713. https://doi.org/10.1016/j.taap.2021.115713
Schyman, Patric, et al. "Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat." Toxicology and applied pharmacology vol. 430 (2021): 115713. doi: https://doi.org/10.1016/j.taap.2021.115713
Schyman P, Printz RL, Pannala VR, AbdulHameed MDM, Estes SK, Shiota C, Boyd KL, Shiota M, Wallqvist A. Genomics and metabolomics of early-stage thioacetamide-induced liver injury: An interspecies study between guinea pig and rat. Toxicol Appl Pharmacol. 2021 Nov 01;430:115713. doi: 10.1016/j.taap.2021.115713. Epub 2021 Sep 04. PMID: 34492290; PMCID: PMC8511347.
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Mesoporous silica nanoparticles containing copper or silver synthesized with a new metal source: Determination of their structure parameters and cytotoxic and irritating effects.

Toxicology and applied pharmacology

Sierosławska A, Borówka A, Rymuszka A, Żukociński G, Sobczak K.
PMID: 34428444
Toxicol Appl Pharmacol. 2021 Oct 15;429:115685. doi: 10.1016/j.taap.2021.115685. Epub 2021 Aug 21.

One of the potential implementation of mesoporous silica nanomaterials (MSNs) is their use in biomedical applications as adsorbents or carriers of various bioactive substances. In this study, we attempted to fabricate silica nanomaterials containing copper and silver that were...

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Sierosławska A, Borówka A, Rymuszka A, et al. Mesoporous silica nanoparticles containing copper or silver synthesized with a new metal source: Determination of their structure parameters and cytotoxic and irritating effects. Toxicol Appl Pharmacol. 2021;429:115685doi: 10.1016/j.taap.2021.115685.
Sierosławska, A., Borówka, A., Rymuszka, A., Żukociński, G., & Sobczak, K. (2021). Mesoporous silica nanoparticles containing copper or silver synthesized with a new metal source: Determination of their structure parameters and cytotoxic and irritating effects. Toxicology and applied pharmacology, 429115685. https://doi.org/10.1016/j.taap.2021.115685
Sierosławska, Anna, et al. "Mesoporous silica nanoparticles containing copper or silver synthesized with a new metal source: Determination of their structure parameters and cytotoxic and irritating effects." Toxicology and applied pharmacology vol. 429 (2021): 115685. doi: https://doi.org/10.1016/j.taap.2021.115685
Sierosławska A, Borówka A, Rymuszka A, Żukociński G, Sobczak K. Mesoporous silica nanoparticles containing copper or silver synthesized with a new metal source: Determination of their structure parameters and cytotoxic and irritating effects. Toxicol Appl Pharmacol. 2021 Oct 15;429:115685. doi: 10.1016/j.taap.2021.115685. Epub 2021 Aug 21. PMID: 34428444.
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PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model.

Toxicology and applied pharmacology

Sun Z, Meng P, Su C, Ji S, Gao Y, Wang H, Tian J, Li C.
PMID: 34428447
Toxicol Appl Pharmacol. 2021 Oct 15;429:115698. doi: 10.1016/j.taap.2021.115698. Epub 2021 Aug 21.

In view of postsynaptic density 95kDA (PSD95) tethers neuronal NO synthase (nNOS) to N-methyl-d-aspartate receptor (NMDAR), the PSD95-nNOS complex represents a therapeutic target of neuropathic pain. This study therefore sought to explore the ability of PCC-0105002, a novel PSD95-nNOS...

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Sun Z, Meng P, Su C, et al. PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model. Toxicol Appl Pharmacol. 2021;429:115698doi: 10.1016/j.taap.2021.115698.
Sun, Z., Meng, P., Su, C., Ji, S., Gao, Y., Wang, H., Tian, J., & Li, C. (2021). PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model. Toxicology and applied pharmacology, 429115698. https://doi.org/10.1016/j.taap.2021.115698
Sun, Zhihong, et al. "PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model." Toxicology and applied pharmacology vol. 429 (2021): 115698. doi: https://doi.org/10.1016/j.taap.2021.115698
Sun Z, Meng P, Su C, Ji S, Gao Y, Wang H, Tian J, Li C. PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model. Toxicol Appl Pharmacol. 2021 Oct 15;429:115698. doi: 10.1016/j.taap.2021.115698. Epub 2021 Aug 21. PMID: 34428447.
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Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress.

Toxicology and applied pharmacology

Wu Z, Geng Y, Buist-Homan M, Moshage H.
PMID: 34979142
Toxicol Appl Pharmacol. 2021 Dec 31;436:115858. doi: 10.1016/j.taap.2021.115858. Epub 2021 Dec 31.

BACKGROUND: The number of patients with non-alcoholic fatty liver disease (NAFLD) is rapidly increasing due to the growing epidemic of obesity. Non-alcoholic steatohepatitis (NASH), the inflammatory stage of NAFLD, is characterized by lipid accumulation in hepatocytes, chronic inflammation and...

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Wu Z, Geng Y, Buist-Homan M, et al. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicol Appl Pharmacol. 2021;436:115858doi: 10.1016/j.taap.2021.115858.
Wu, Z., Geng, Y., Buist-Homan, M., & Moshage, H. (2021). Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicology and applied pharmacology, 436115858. https://doi.org/10.1016/j.taap.2021.115858
Wu, Zongmei, et al. "Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress." Toxicology and applied pharmacology vol. 436 (2021): 115858. doi: https://doi.org/10.1016/j.taap.2021.115858
Wu Z, Geng Y, Buist-Homan M, Moshage H. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicol Appl Pharmacol. 2021 Dec 31;436:115858. doi: 10.1016/j.taap.2021.115858. Epub 2021 Dec 31. PMID: 34979142.
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Showing 505 to 511 of 511 entries