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Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection.

Scientific reports

Byun JY, Koh YT, Jang SY, Witcher JW, Chan JR, Pustilnik A, Daniels MJ, Kim YH, Suh KH, Linnik MD, Lee YM.
PMID: 34548595
Sci Rep. 2021 Sep 21;11(1):18671. doi: 10.1038/s41598-021-98255-7.

The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, https://doi.org/10.1186/s13075-016-0988-z , 2016). This study describes the...

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Byun JY, Koh YT, Jang SY, et al. Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection. Sci Rep. 2021;11(1):18671doi: 10.1038/s41598-021-98255-7.
Byun, J. Y., Koh, Y. T., Jang, S. Y., Witcher, J. W., Chan, J. R., Pustilnik, A., Daniels, M. J., Kim, Y. H., Suh, K. H., Linnik, M. D., & Lee, Y. M. (2021). Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection. Scientific reports, 11(1), 18671. https://doi.org/10.1038/s41598-021-98255-7
Byun, Joo-Yun, et al. "Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection." Scientific reports vol. 11,1 (2021): 18671. doi: https://doi.org/10.1038/s41598-021-98255-7
Byun JY, Koh YT, Jang SY, Witcher JW, Chan JR, Pustilnik A, Daniels MJ, Kim YH, Suh KH, Linnik MD, Lee YM. Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection. Sci Rep. 2021 Sep 21;11(1):18671. doi: 10.1038/s41598-021-98255-7. PMID: 34548595; PMCID: PMC8455565.
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The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia.

Cancers

Gerousi M, Psomopoulos F, Kotta K, Tsagiopoulou M, Stavroyianni N, Anagnostopoulos A, Anastasiadis A, Gkanidou M, Kotsianidis I, Ntoufa S, Stamatopoulos K.
PMID: 33466695
Cancers (Basel). 2021 Jan 14;13(2). doi: 10.3390/cancers13020285.

It has been proposed that vitamin D may play a role in prevention and treatment of cancer while epidemiological studies have linked vitamin D insufficiency to adverse disease outcomes in various B cell malignancies, including chronic lymphocytic leukemia (CLL)....

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Gerousi M, Psomopoulos F, Kotta K, et al. The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia. Cancers (Basel). 2021;13(2)doi: 10.3390/cancers13020285.
Gerousi, M., Psomopoulos, F., Kotta, K., Tsagiopoulou, M., Stavroyianni, N., Anagnostopoulos, A., Anastasiadis, A., Gkanidou, M., Kotsianidis, I., Ntoufa, S., & Stamatopoulos, K. (2021). The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia. Cancers, 13(2), . https://doi.org/10.3390/cancers13020285
Gerousi, Marina, et al. "The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia." Cancers vol. 13,2 (2021). doi: https://doi.org/10.3390/cancers13020285
Gerousi M, Psomopoulos F, Kotta K, Tsagiopoulou M, Stavroyianni N, Anagnostopoulos A, Anastasiadis A, Gkanidou M, Kotsianidis I, Ntoufa S, Stamatopoulos K. The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia. Cancers (Basel). 2021 Jan 14;13(2). doi: 10.3390/cancers13020285. PMID: 33466695; PMCID: PMC7828837.
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Feasibility of Immunoadsorption plasmapheresis in an infant for ABO-incompatible solid organ transplant-A reality.

Pediatric transplantation

Gaur S, Paul PP, Motamarri M, Tulla SR.
PMID: 34057793
Pediatr Transplant. 2021 Nov;25(7):e14064. doi: 10.1111/petr.14064. Epub 2021 May 31.

BACKGROUND: Immunoadsorption (IA) plasmapheresis is standard modality for pretransplant desensitization in ABO-incompatible solid organ transplants though technically challenging when considered for an infant or a child less than 10 kg due to non-availability of pediatric immunoadsorption (IA) columns. The...

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Gaur S, Paul PP, Motamarri M, et al. Feasibility of Immunoadsorption plasmapheresis in an infant for ABO-incompatible solid organ transplant-A reality. Pediatr Transplant. 2021;25(7):e14064doi: 10.1111/petr.14064.
Gaur, S., Paul, P. P., Motamarri, M., & Tulla, S. R. (2021). Feasibility of Immunoadsorption plasmapheresis in an infant for ABO-incompatible solid organ transplant-A reality. Pediatric transplantation, 25(7), e14064. https://doi.org/10.1111/petr.14064
Gaur, Saumil, et al. "Feasibility of Immunoadsorption plasmapheresis in an infant for ABO-incompatible solid organ transplant-A reality." Pediatric transplantation vol. 25,7 (2021): e14064. doi: https://doi.org/10.1111/petr.14064
Gaur S, Paul PP, Motamarri M, Tulla SR. Feasibility of Immunoadsorption plasmapheresis in an infant for ABO-incompatible solid organ transplant-A reality. Pediatr Transplant. 2021 Nov;25(7):e14064. doi: 10.1111/petr.14064. Epub 2021 May 31. PMID: 34057793.
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New-generation diagnostics in inflammatory skin diseases: Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in cutaneous lupus erythematosus.

Experimental dermatology

Sinem Bağcı I, Aoki R, Vladimirova G, Ergün E, Ruzicka T, Sárdy M, French LE, Hartmann D.
PMID: 33345402
Exp Dermatol. 2021 May;30(5):684-690. doi: 10.1111/exd.14265. Epub 2021 Jan 21.

Ex vivo confocal laser scanning microscopy (CLSM) offers real-time examination of excised tissue in reflectance, fluorescence and digital haematoxylin-eosin (H&E)-like staining modes enabling application of fluorescent-labelled antibodies. We aimed to assess the diagnostic performance of ex vivo CLSM in...

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Sinem Bağcı I, Aoki R, Vladimirova G, et al. New-generation diagnostics in inflammatory skin diseases: Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in cutaneous lupus erythematosus. Exp Dermatol. 2021;30(5):684-690doi: 10.1111/exd.14265.
Sinem Bağcı, I., Aoki, R., Vladimirova, G., Ergün, E., Ruzicka, T., Sárdy, M., French, L. E., & Hartmann, D. (2021). New-generation diagnostics in inflammatory skin diseases: Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in cutaneous lupus erythematosus. Experimental dermatology, 30(5), 684-690. https://doi.org/10.1111/exd.14265
Sinem Bağcı, Işın, et al. "New-generation diagnostics in inflammatory skin diseases: Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in cutaneous lupus erythematosus." Experimental dermatology vol. 30,5 (2021): 684-690. doi: https://doi.org/10.1111/exd.14265
Sinem Bağcı I, Aoki R, Vladimirova G, Ergün E, Ruzicka T, Sárdy M, French LE, Hartmann D. New-generation diagnostics in inflammatory skin diseases: Immunofluorescence and histopathological assessment using ex vivo confocal laser scanning microscopy in cutaneous lupus erythematosus. Exp Dermatol. 2021 May;30(5):684-690. doi: 10.1111/exd.14265. Epub 2021 Jan 21. PMID: 33345402.
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The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory.

Frontiers in immunology

Karnell JL, Ettinger R.
PMID: 22566888
Front Immunol. 2012 Jan 24;3:2. doi: 10.3389/fimmu.2012.00002. eCollection 2012.

To date, IL-21 stands out as the most influential cytokine for human B cell activation and differentiation. Indeed, when compared to other important B cell tropic cytokines such as IL-2, IL-4, IL-6 and IL-10, IL-21 is clearly the most...

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Karnell JL, Ettinger R. The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory. Front Immunol. 2012;3:2doi: 10.3389/fimmu.2012.00002.
Karnell, J. L., & Ettinger, R. (2012). The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory. Frontiers in immunology, 32. https://doi.org/10.3389/fimmu.2012.00002
Karnell, Jodi L, and Ettinger, Rachel. "The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory." Frontiers in immunology vol. 3 (2012): 2. doi: https://doi.org/10.3389/fimmu.2012.00002
Karnell JL, Ettinger R. The Interplay of IL-21 and BAFF in the Formation and Maintenance of Human B Cell Memory. Front Immunol. 2012 Jan 24;3:2. doi: 10.3389/fimmu.2012.00002. eCollection 2012. PMID: 22566888; PMCID: PMC3342005.
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Monoclonal antibodies used to isolate IgM from chicken bile and avian sera and to detect specific IgM in chicken sera.

Avian pathology : journal of the W.V.P.A

Mockett AP.
PMID: 18766536
Avian Pathol. 1986;15(3):337-48. doi: 10.1080/03079458608436297.

Four hybridoma cell lines (designated M1, M10, M11, M31) were established which secrete antibody specific for chicken IgM. The specificity for the IgM heavy chain was shown by using ELISAs to screen for antibodies to IgM, IgA and IgG....

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Mockett AP. Monoclonal antibodies used to isolate IgM from chicken bile and avian sera and to detect specific IgM in chicken sera. Avian Pathol. 1986;15(3):337-48doi: 10.1080/03079458608436297.
Mockett, A. P. (1986). Monoclonal antibodies used to isolate IgM from chicken bile and avian sera and to detect specific IgM in chicken sera. Avian pathology : journal of the W.V.P.A, 15(3), 337-48. https://doi.org/10.1080/03079458608436297
Mockett, A P. "Monoclonal antibodies used to isolate IgM from chicken bile and avian sera and to detect specific IgM in chicken sera." Avian pathology : journal of the W.V.P.A vol. 15,3 (1986): 337-48. doi: https://doi.org/10.1080/03079458608436297
Mockett AP. Monoclonal antibodies used to isolate IgM from chicken bile and avian sera and to detect specific IgM in chicken sera. Avian Pathol. 1986;15(3):337-48. doi: 10.1080/03079458608436297. PMID: 18766536.
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Evaluation of B-cell intracellular signaling by monitoring the PI3K-Akt axis in patients with common variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome.

Cytometry. Part B, Clinical cytometry

Del Pino-Molina L, Torres Canizales JM, Rodríguez-Pena R, López-Granados E.
PMID: 32961022
Cytometry B Clin Cytom. 2021 Jul;100(4):460-466. doi: 10.1002/cyto.b.21956. Epub 2020 Sep 22.

BACKGROUND: Primary antibody deficiencies (PADs) are characterized by hypogammaglobulinemia and impaired B-cell differentiation. Patients with common variable immunodeficiency (CVID) present severe reductions in at least 2 serum immunoglobulins and impaired terminal differentiation of B cells. Most patients with CVID...

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Del Pino-Molina L, Torres Canizales JM, Rodríguez-Pena R, et al. Evaluation of B-cell intracellular signaling by monitoring the PI3K-Akt axis in patients with common variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome. Cytometry B Clin Cytom. 2020;100(4):460-466doi: 10.1002/cyto.b.21956.
Del Pino-Molina, L., Torres Canizales, J. M., Rodríguez-Pena, R., & López-Granados, E. (2021). Evaluation of B-cell intracellular signaling by monitoring the PI3K-Akt axis in patients with common variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome. Cytometry. Part B, Clinical cytometry, 100(4), 460-466. https://doi.org/10.1002/cyto.b.21956
Del Pino-Molina, Lucía, et al. "Evaluation of B-cell intracellular signaling by monitoring the PI3K-Akt axis in patients with common variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome." Cytometry. Part B, Clinical cytometry vol. 100,4 (2021): 460-466. doi: https://doi.org/10.1002/cyto.b.21956
Del Pino-Molina L, Torres Canizales JM, Rodríguez-Pena R, López-Granados E. Evaluation of B-cell intracellular signaling by monitoring the PI3K-Akt axis in patients with common variable immunodeficiency and activated phosphoinositide 3-kinase delta syndrome. Cytometry B Clin Cytom. 2021 Jul;100(4):460-466. doi: 10.1002/cyto.b.21956. Epub 2020 Sep 22. PMID: 32961022.
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Preparation of anfi-CD3 and anti-IgM&mgr; chain bispecific antibody by cell fusion.

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

Su J, Zhang YL, Guo ZB, Che XY, Wang XN.
PMID: 12426160
Di Yi Jun Yi Da Xue Xue Bao. 2001;21(12):902-905.

OBJECTIVE: To prepare anti-CD3 and anti-Igm&mgr; chain bispecific antibody (BsAb) by means of cell fusion and assess the stability and activity of the hybrid hybridoma. METHODS: Mouse hybridoma cell line secreting anti-human CD3 monoclonal antibody (mAb) was trans formed...

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Su J, Zhang YL, Guo ZB, et al. Preparation of anfi-CD3 and anti-IgM&mgr; chain bispecific antibody by cell fusion. Di Yi Jun Yi Da Xue Xue Bao. 2001;21(12):902-905
Su, J., Zhang, Y. L., Guo, Z. B., Che, X. Y., & Wang, X. N. (2001). Preparation of anfi-CD3 and anti-IgM&mgr; chain bispecific antibody by cell fusion. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 21(12), 902-905.
Su, Jin, et al. "Preparation of anfi-CD3 and anti-IgM&mgr; chain bispecific antibody by cell fusion." Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA vol. 21,12 (2001): 902-905.
Su J, Zhang YL, Guo ZB, Che XY, Wang XN. Preparation of anfi-CD3 and anti-IgM&mgr; chain bispecific antibody by cell fusion. Di Yi Jun Yi Da Xue Xue Bao. 2001;21(12):902-905. PMID: 12426160.
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Cytolytic and fluorescent detection of H-Y antigen on preimplantation mouse embryos.

Theriogenology

White KL, Lindner GM, Anderson GB, Bondurant RH.
PMID: 16725818
Theriogenology. 1983 May;19(5):701-5. doi: 10.1016/0093-691x(83)90111-5.

Monoclonal antibodies to histocompatibility (H-Y) antigen, of IgM subclass, were used to immunologically determine the sex of mouse embryos prior to transfer to pseudopregnant recipients. Two experiments were performed, one using cytolysis of H-Y positive embryos and the other...

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White KL, Lindner GM, Anderson GB, et al. Cytolytic and fluorescent detection of H-Y antigen on preimplantation mouse embryos. Theriogenology. 1983;19(5):701-5doi: 10.1016/0093-691x(83)90111-5.
White, K. L., Lindner, G. M., Anderson, G. B., & Bondurant, R. H. (1983). Cytolytic and fluorescent detection of H-Y antigen on preimplantation mouse embryos. Theriogenology, 19(5), 701-5. https://doi.org/10.1016/0093-691x(83)90111-5
White, K L, et al. "Cytolytic and fluorescent detection of H-Y antigen on preimplantation mouse embryos." Theriogenology vol. 19,5 (1983): 701-5. doi: https://doi.org/10.1016/0093-691x(83)90111-5
White KL, Lindner GM, Anderson GB, Bondurant RH. Cytolytic and fluorescent detection of H-Y antigen on preimplantation mouse embryos. Theriogenology. 1983 May;19(5):701-5. doi: 10.1016/0093-691x(83)90111-5. PMID: 16725818.
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Bullous Systemic Lupus Erythematosus: Case report.

International archives of otorhinolaryngology

Miziara ID, Mahmoud A, Chagury AA, Alves RD.
PMID: 25992032
Int Arch Otorhinolaryngol. 2013 Jul;17(3):344-6. doi: 10.7162/S1809-977720130003000016.

INTRODUCTION:  Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated disease with subepidermal blisters. It is a rare form of presentation of SLE that occurs in less than 5% of cases of lupus.CASE REPORT:  A 27-year-old, female, FRS patient reported...

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Miziara ID, Mahmoud A, Chagury AA, et al. Bullous Systemic Lupus Erythematosus: Case report. Int Arch Otorhinolaryngol. 2013;17(3):344-6doi: 10.7162/S1809-977720130003000016.
Miziara, I. D., Mahmoud, A., Chagury, A. A., & Alves, R. D. (2013). Bullous Systemic Lupus Erythematosus: Case report. International archives of otorhinolaryngology, 17(3), 344-6. https://doi.org/10.7162/S1809-977720130003000016
Miziara, Ivan Dieb, et al. "Bullous Systemic Lupus Erythematosus: Case report." International archives of otorhinolaryngology vol. 17,3 (2013): 344-6. doi: https://doi.org/10.7162/S1809-977720130003000016
Miziara ID, Mahmoud A, Chagury AA, Alves RD. Bullous Systemic Lupus Erythematosus: Case report. Int Arch Otorhinolaryngol. 2013 Jul;17(3):344-6. doi: 10.7162/S1809-977720130003000016. PMID: 25992032; PMCID: PMC4423270.
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Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas.

Cell communication and signaling : CCS

Schrader A, Meyer K, von Bonin F, Vockerodt M, Walther N, Hand E, Ulrich A, Matulewicz K, Lenze D, Hummel M, Kieser A, Engelke M, Trümper L, Kube D.
PMID: 23253402
Cell Commun Signal. 2012 Dec 20;10(1):43. doi: 10.1186/1478-811X-10-43.

BACKGROUND: Aggressive Non-Hodgkin lymphomas (NHL) are a group of lymphomas derived from germinal centre B cells which display a heterogeneous pattern of oncogenic pathway activation. We postulate that specific immune response associated signalling, affecting gene transcription networks, may be...

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Schrader A, Meyer K, von Bonin F, et al. Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas. Cell Commun Signal. 2012;10(1):43doi: 10.1186/1478-811X-10-43.
Schrader, A., Meyer, K., von Bonin, F., Vockerodt, M., Walther, N., Hand, E., Ulrich, A., Matulewicz, K., Lenze, D., Hummel, M., Kieser, A., Engelke, M., Trümper, L., & Kube, D. (2012). Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas. Cell communication and signaling : CCS, 10(1), 43. https://doi.org/10.1186/1478-811X-10-43
Schrader, Alexandra, et al. "Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas." Cell communication and signaling : CCS vol. 10,1 (2012): 43. doi: https://doi.org/10.1186/1478-811X-10-43
Schrader A, Meyer K, von Bonin F, Vockerodt M, Walther N, Hand E, Ulrich A, Matulewicz K, Lenze D, Hummel M, Kieser A, Engelke M, Trümper L, Kube D. Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas. Cell Commun Signal. 2012 Dec 20;10(1):43. doi: 10.1186/1478-811X-10-43. PMID: 23253402; PMCID: PMC3566944.
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Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma.

Toxicology reports

Fang JL, Beland FA, Tang Y, Roffler SR.
PMID: 33437656
Toxicol Rep. 2020 Dec 26;8:148-154. doi: 10.1016/j.toxrep.2020.12.022. eCollection 2021.

Polyethylene glycol (PEG) is a biocompatible polymer used in biotherapeutics to increase bioavailability, reduce the frequency of administration, and optimize pharmacokinetics. Anti-PEG antibodies have been detected in healthy individuals and may decrease efficacy and alter the pharmacokinetics of PEGylated...

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Fang JL, Beland FA, Tang Y, et al. Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma. Toxicol Rep. 2020;8:148-154doi: 10.1016/j.toxrep.2020.12.022.
Fang, J. L., Beland, F. A., Tang, Y., & Roffler, S. R. (2021). Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma. Toxicology reports, 8148-154. https://doi.org/10.1016/j.toxrep.2020.12.022
Fang, Jia-Long, et al. "Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma." Toxicology reports vol. 8 (2021): 148-154. doi: https://doi.org/10.1016/j.toxrep.2020.12.022
Fang JL, Beland FA, Tang Y, Roffler SR. Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma. Toxicol Rep. 2020 Dec 26;8:148-154. doi: 10.1016/j.toxrep.2020.12.022. eCollection 2021. PMID: 33437656; PMCID: PMC7787990.
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Showing 13 to 24 of 30 entries