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Showing 169 to 174 of 174 entries
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Kidney and Urinary Tract Involvement in Epidermolysis Bullosa: Is Routine Follow-Up Necessary?.

Dermatology practical & conceptual

Cicek N, Yildiz N, Asadov R, Yucelten AD, Tugtepe H, Alpay H.
PMID: 34123558
Dermatol Pract Concept. 2021 May 20;11(3):e2021051. doi: 10.5826/dpc.1103a51. eCollection 2021 May.

BACKGROUND: Several renal and urinary tract complications have been reported in patients with epidermolysis bullosa.OBJECTIVE: This study investigated kidney and urinary tract involvement in patients with epidermolysis bullosa.PATIENTS AND METHODS: Patients with epidermolysis bullosa in treatment at the Dermatology...

CD4 T Cell-Dependent Rejection of Beta-2 Microglobulin Null Mismatch Repair-Deficient Tumors.

Cancer discovery

Germano G, Lu S, Rospo G, Lamba S, Rousseau B, Fanelli S, Stenech D, Le DT, Hays J, Totaro MG, Amodio V, Chilà R, Mondino A, Diaz LA, Di Nicolantonio F, Bardelli A.
PMID: 33653693
Cancer Discov. 2021 Jul;11(7):1844-1859. doi: 10.1158/2159-8290.CD-20-0987. Epub 2021 Mar 02.

Inactivation of beta-2 microglobulin (B2M) is considered a determinant of resistance to immune checkpoint inhibitors (ICPi) in melanoma and lung cancers. In contrast,

Venus flytrap or pas de trois? The dynamics of MHC class I molecules.

Current opinion in immunology

Jantz-Naeem N, Springer S.
PMID: 33993034
Curr Opin Immunol. 2021 Jun;70:82-89. doi: 10.1016/j.coi.2021.04.004. Epub 2021 May 13.

The peptide binding site of major histocompatibility complex (MHC) class I molecules is natively unfolded when devoid of peptides. Peptide binding stabilizes the structure and slows the dynamics, but peptide-specific and subtype-specific motions influence, and are influenced by, interaction...

Current updates on protein as biomarkers for diabetic kidney disease: a systematic review.

Therapeutic advances in endocrinology and metabolism

Sauriasari R, Safitri DD, Azmi NU.
PMID: 34721837
Ther Adv Endocrinol Metab. 2021 Oct 27;12:20420188211049612. doi: 10.1177/20420188211049612. eCollection 2021.

BACKGROUND: In the past decade, researchers have been focused on discovering protein biomarkers for diabetic kidney disease. This paper aims to search for, analyze, and synthesize current updates regarding the development of these efforts.METHODS: We systematically searched the ScienceDirect,...

Successful Treatment of Nephrotic Syndrome due to Collapsing Focal Segmental Glomerulosclerosis Accompanied by Acute Interstitial Nephritis: A Case Report.

Internal medicine (Tokyo, Japan)

Shima H, Doi T, Okamoto T, Higashiguchi Y, Harada M, Inoue T, Tashiro M, Wariishi S, Takamatsu N, Kawahara K, Okada K, Minakuchi J.
PMID: 34803098
Intern Med. 2021 Nov 20; doi: 10.2169/internalmedicine.8258-21. Epub 2021 Nov 20.

A 39-year-old woman was hospitalized for nephrotic syndrome. Laboratory test results showed increased serum creatinine levels and urinary excretions of beta-2-microglobulin, and N-acetyl-beta-D-glucosaminidase. A renal biopsy revealed collapsing focal segmental glomerulosclerosis (FSGS) and acute interstitial nephritis. Despite treatment with...

Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.

Amino acids

Zhou Z, Liu XQ, Zhang SQ, Qi XM, Zhang Q, Yard B, Wu YG.
PMID: 33811534
Amino Acids. 2021 May;53(5):687-700. doi: 10.1007/s00726-021-02975-z. Epub 2021 Apr 03.

Diabetic nephropathy (DN) is one of the major complications of diabetes and contributes significantly towards end-stage renal disease. Previous studies have identified the gene encoding carnosinase (CN-1) as a predisposing factor for DN. Despite this fact, the relationship of...

Showing 169 to 174 of 174 entries