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Design and Immunological Validation of .

Frontiers in immunology

Neckermann P, Boilesen DR, Willert T, Pertl C, Schrödel S, Thirion C, Asbach B, Holst PJ, Wagner R.
PMID: 34777375
Front Immunol. 2021 Oct 28;12:761214. doi: 10.3389/fimmu.2021.761214. eCollection 2021.

Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high. Thus, an efficient therapy, such as a therapeutic vaccine, is urgently...

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Neckermann P, Boilesen DR, Willert T, et al. Design and Immunological Validation of . Front Immunol. 2021;12:761214doi: 10.3389/fimmu.2021.761214.
Neckermann, P., Boilesen, D. R., Willert, T., Pertl, C., Schrödel, S., Thirion, C., Asbach, B., Holst, P. J., & Wagner, R. (2021). Design and Immunological Validation of . Frontiers in immunology, 12761214. https://doi.org/10.3389/fimmu.2021.761214
Neckermann, Patrick, et al. "Design and Immunological Validation of ." Frontiers in immunology vol. 12 (2021): 761214. doi: https://doi.org/10.3389/fimmu.2021.761214
Neckermann P, Boilesen DR, Willert T, Pertl C, Schrödel S, Thirion C, Asbach B, Holst PJ, Wagner R. Design and Immunological Validation of . Front Immunol. 2021 Oct 28;12:761214. doi: 10.3389/fimmu.2021.761214. eCollection 2021. PMID: 34777375; PMCID: PMC8581358.
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Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain.

Viruses

Nazerai L, Buus S, Stryhn A, Thomsen AR, Christensen JP.
PMID: 34835021
Viruses. 2021 Nov 03;13(11). doi: 10.3390/v13112215.

It is generally believed that a successful Zika virus (ZIKV) vaccine should induce neutralizing antibodies against the ZIKV envelope (E) protein to efficiently halt viral infection. However, E-specific neutralizing antibodies have been implicated in a phenomenon called antibody-dependent enhancement,...

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Nazerai L, Buus S, Stryhn A, et al. Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain. Viruses. 2021;13(11)doi: 10.3390/v13112215.
Nazerai, L., Buus, S., Stryhn, A., Thomsen, A. R., & Christensen, J. P. (2021). Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain. Viruses, 13(11), . https://doi.org/10.3390/v13112215
Nazerai, Loulieta, et al. "Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain." Viruses vol. 13,11 (2021). doi: https://doi.org/10.3390/v13112215
Nazerai L, Buus S, Stryhn A, Thomsen AR, Christensen JP. Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain. Viruses. 2021 Nov 03;13(11). doi: 10.3390/v13112215. PMID: 34835021; PMCID: PMC8625593.
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HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY.

Molecular & cellular proteomics : MCP

Demmers LC, Wu W, Heck AJR.
PMID: 33933681
Mol Cell Proteomics. 2021;20:100089. doi: 10.1016/j.mcpro.2021.100089. Epub 2021 Apr 29.

Human leukocyte antigen (HLA) molecules play critical roles in our adaptive immune system by signaling a cell's health status to the immune system, through presentation of small peptides. Understanding HLA biology is important because of its prominent role in...

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Demmers LC, Wu W, Heck AJR. HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY. Mol Cell Proteomics. 2021;20:100089doi: 10.1016/j.mcpro.2021.100089.
Demmers, L. C., Wu, W., & Heck, A. J. R. (2021). HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY. Molecular & cellular proteomics : MCP, 20100089. https://doi.org/10.1016/j.mcpro.2021.100089
Demmers, Laura C, et al. "HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY." Molecular & cellular proteomics : MCP vol. 20 (2021): 100089. doi: https://doi.org/10.1016/j.mcpro.2021.100089
Demmers LC, Wu W, Heck AJR. HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY. Mol Cell Proteomics. 2021;20:100089. doi: 10.1016/j.mcpro.2021.100089. Epub 2021 Apr 29. PMID: 33933681.
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Discordant Expression of Ii and HLA-DR in Thyrocytes: A Possible Pathogenetic Factor in Hashimoto's Thyroiditis.

Endocrine pathology

Yu M, Xu M, Savas L, Khan A.
PMID: 12114710
Endocr Pathol. 1998;9(3):201-208. doi: 10.1007/BF02739959.

Hashimoto's thyroiditis is the archetype of organ-specific autoimmune disease. The key pathogenetic feature is the activation of thyroid-specific T-cells by properly presented endogenous thyroid antigens. There is strong indication that thyrocytes themselves present self-antigens, based on the finding of...

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Yu M, Xu M, Savas L, et al. Discordant Expression of Ii and HLA-DR in Thyrocytes: A Possible Pathogenetic Factor in Hashimoto's Thyroiditis. Endocr Pathol. 1998;9(3):201-208doi: 10.1007/BF02739959.
Yu, M., Xu, M., Savas, L., & Khan, A. (1998). Discordant Expression of Ii and HLA-DR in Thyrocytes: A Possible Pathogenetic Factor in Hashimoto's Thyroiditis. Endocrine pathology, 9(3), 201-208. https://doi.org/10.1007/BF02739959
Yu, Mujun, et al. "Discordant Expression of Ii and HLA-DR in Thyrocytes: A Possible Pathogenetic Factor in Hashimoto's Thyroiditis." Endocrine pathology vol. 9,3 (1998): 201-208. doi: https://doi.org/10.1007/BF02739959
Yu M, Xu M, Savas L, Khan A. Discordant Expression of Ii and HLA-DR in Thyrocytes: A Possible Pathogenetic Factor in Hashimoto's Thyroiditis. Endocr Pathol. 1998;9(3):201-208. doi: 10.1007/BF02739959. PMID: 12114710.
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CD74 interacts with APP and suppresses the production of Abeta.

Molecular neurodegeneration

Matsuda S, Matsuda Y, D'Adamio L.
PMID: 19849849
Mol Neurodegener. 2009 Oct 22;4:41. doi: 10.1186/1750-1326-4-41.

BACKGROUND: Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of beta amyloid (Abeta) peptides. Abeta is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing by beta-secretase and gamma-secretase.RESULTS: Here, we show that...

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Matsuda S, Matsuda Y, D'Adamio L. CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener. 2009;4:41doi: 10.1186/1750-1326-4-41.
Matsuda, S., Matsuda, Y., & D'Adamio, L. (2009). CD74 interacts with APP and suppresses the production of Abeta. Molecular neurodegeneration, 441. https://doi.org/10.1186/1750-1326-4-41
Matsuda, Shuji, et al. "CD74 interacts with APP and suppresses the production of Abeta." Molecular neurodegeneration vol. 4 (2009): 41. doi: https://doi.org/10.1186/1750-1326-4-41
Matsuda S, Matsuda Y, D'Adamio L. CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener. 2009 Oct 22;4:41. doi: 10.1186/1750-1326-4-41. PMID: 19849849; PMCID: PMC2770512.
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Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes.

Frontiers in immunology

Zhou Z, Jensen PE.
PMID: 24009614
Front Immunol. 2013 Aug 29;4:262. doi: 10.3389/fimmu.2013.00262. eCollection 2013.

Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular...

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Zhou Z, Jensen PE. Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes. Front Immunol. 2013;4:262doi: 10.3389/fimmu.2013.00262.
Zhou, Z., & Jensen, P. E. (2013). Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes. Frontiers in immunology, 4262. https://doi.org/10.3389/fimmu.2013.00262
Zhou, Zemin, and Jensen, Peter E. "Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes." Frontiers in immunology vol. 4 (2013): 262. doi: https://doi.org/10.3389/fimmu.2013.00262
Zhou Z, Jensen PE. Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes. Front Immunol. 2013 Aug 29;4:262. doi: 10.3389/fimmu.2013.00262. eCollection 2013. PMID: 24009614; PMCID: PMC3756536.
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Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions.

Journal of nutrition and metabolism

Danner OK, Matthews LR, Francis S, Rao VN, Harvey CP, Tobin RP, Wilson KL, Alema-Mensah E, Newell Rogers MK, Childs EW.
PMID: 27313879
J Nutr Metab. 2016;2016:4280876. doi: 10.1155/2016/4280876. Epub 2016 May 30.

Class II invariant chain peptide (CLIP) expression has been demonstrated to play a pivotal role in the regulation of B cell function after nonspecific polyclonal expansion. Several studies have shown vitamin D3 helps regulate the immune response. We hypothesized...

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Danner OK, Matthews LR, Francis S, et al. Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. J Nutr Metab. 2016;2016:4280876doi: 10.1155/2016/4280876.
Danner, O. K., Matthews, L. R., Francis, S., Rao, V. N., Harvey, C. P., Tobin, R. P., Wilson, K. L., Alema-Mensah, E., Newell Rogers, M. K., & Childs, E. W. (2016). Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. Journal of nutrition and metabolism, 20164280876. https://doi.org/10.1155/2016/4280876
Danner, Omar K, et al. "Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions." Journal of nutrition and metabolism vol. 2016 (2016): 4280876. doi: https://doi.org/10.1155/2016/4280876
Danner OK, Matthews LR, Francis S, Rao VN, Harvey CP, Tobin RP, Wilson KL, Alema-Mensah E, Newell Rogers MK, Childs EW. Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. J Nutr Metab. 2016;2016:4280876. doi: 10.1155/2016/4280876. Epub 2016 May 30. PMID: 27313879; PMCID: PMC4904097.
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The Other Function: Class II-Restricted Antigen Presentation by B Cells.

Frontiers in immunology

Adler LN, Jiang W, Bhamidipati K, Millican M, Macaubas C, Hung SC, Mellins ED.
PMID: 28386257
Front Immunol. 2017 Mar 23;8:319. doi: 10.3389/fimmu.2017.00319. eCollection 2017.

Mature B lymphocytes (B cells) recognize antigens using their B cell receptor (BCR) and are activated to become antibody-producing cells. In addition, and integral to the development of a high-affinity antibodies, B cells utilize the specialized major histocompatibility complex...

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Adler LN, Jiang W, Bhamidipati K, et al. The Other Function: Class II-Restricted Antigen Presentation by B Cells. Front Immunol. 2017;8:319doi: 10.3389/fimmu.2017.00319.
Adler, L. N., Jiang, W., Bhamidipati, K., Millican, M., Macaubas, C., Hung, S. C., & Mellins, E. D. (2017). The Other Function: Class II-Restricted Antigen Presentation by B Cells. Frontiers in immunology, 8319. https://doi.org/10.3389/fimmu.2017.00319
Adler, Lital N, et al. "The Other Function: Class II-Restricted Antigen Presentation by B Cells." Frontiers in immunology vol. 8 (2017): 319. doi: https://doi.org/10.3389/fimmu.2017.00319
Adler LN, Jiang W, Bhamidipati K, Millican M, Macaubas C, Hung SC, Mellins ED. The Other Function: Class II-Restricted Antigen Presentation by B Cells. Front Immunol. 2017 Mar 23;8:319. doi: 10.3389/fimmu.2017.00319. eCollection 2017. PMID: 28386257; PMCID: PMC5362600.
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Dynamic Changes in the Intracellular Association of Selected Rab Small GTPases with MHC Class II and DM during Dendritic Cell Maturation.

Frontiers in immunology

Pérez-Montesinos G, López-Ortega O, Piedra-Reyes J, Bonifaz LC, Moreno J.
PMID: 28396666
Front Immunol. 2017 Mar 27;8:340. doi: 10.3389/fimmu.2017.00340. eCollection 2017.

Antigen processing for presentation by major histocompatibility complex class II (MHCII) molecules requires the latter to travel through the endocytic pathway together with its chaperons: the invariant chain (Ii) and DM. Nevertheless, the nature of the compartments where MHCII...

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Pérez-Montesinos G, López-Ortega O, Piedra-Reyes J, et al. Dynamic Changes in the Intracellular Association of Selected Rab Small GTPases with MHC Class II and DM during Dendritic Cell Maturation. Front Immunol. 2017;8:340doi: 10.3389/fimmu.2017.00340.
Pérez-Montesinos, G., López-Ortega, O., Piedra-Reyes, J., Bonifaz, L. C., & Moreno, J. (2017). Dynamic Changes in the Intracellular Association of Selected Rab Small GTPases with MHC Class II and DM during Dendritic Cell Maturation. Frontiers in immunology, 8340. https://doi.org/10.3389/fimmu.2017.00340
Pérez-Montesinos, Gibrán, et al. "Dynamic Changes in the Intracellular Association of Selected Rab Small GTPases with MHC Class II and DM during Dendritic Cell Maturation." Frontiers in immunology vol. 8 (2017): 340. doi: https://doi.org/10.3389/fimmu.2017.00340
Pérez-Montesinos G, López-Ortega O, Piedra-Reyes J, Bonifaz LC, Moreno J. Dynamic Changes in the Intracellular Association of Selected Rab Small GTPases with MHC Class II and DM during Dendritic Cell Maturation. Front Immunol. 2017 Mar 27;8:340. doi: 10.3389/fimmu.2017.00340. eCollection 2017. PMID: 28396666; PMCID: PMC5367080.
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Hemocyanin Subunit Composition and Oxygen Binding in Two Species of the Lobster Genus Homarus and Their Hybrids.

The Biological bulletin

Mangum CP.
PMID: 29300617
Biol Bull. 1993 Feb;184(1):105-113. doi: 10.2307/1542384.

The monomeric subunit composition and O2 binding properties of the hemocyanins (Hcs) of Homarus americanus, H. gammarus and their hybrids are very similar, though not identical. H. americanus Hc has six major electrophoretically separable polypeptide chains; H. gammarus Hc...

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Mangum CP. Hemocyanin Subunit Composition and Oxygen Binding in Two Species of the Lobster Genus Homarus and Their Hybrids. Biol Bull. 1993;184(1):105-113doi: 10.2307/1542384.
Mangum, C. P. (1993). Hemocyanin Subunit Composition and Oxygen Binding in Two Species of the Lobster Genus Homarus and Their Hybrids. The Biological bulletin, 184(1), 105-113. https://doi.org/10.2307/1542384
Mangum, C P. "Hemocyanin Subunit Composition and Oxygen Binding in Two Species of the Lobster Genus Homarus and Their Hybrids." The Biological bulletin vol. 184,1 (1993): 105-113. doi: https://doi.org/10.2307/1542384
Mangum CP. Hemocyanin Subunit Composition and Oxygen Binding in Two Species of the Lobster Genus Homarus and Their Hybrids. Biol Bull. 1993 Feb;184(1):105-113. doi: 10.2307/1542384. PMID: 29300617.
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Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis.

Biomedical reports

Akasaka J, Uekuri C, Shigetomi H, Koike M, Kobayashi H.
PMID: 24648885
Biomed Rep. 2013 Jan;1(1):13-17. doi: 10.3892/br.2012.19. Epub 2012 Oct 11.

Endometriosis is associated with pelvic pain and female infertility. Endometriosis induces inflammation and is vulnerable to oxidative stress damage. To update and summarize the literature concerning the mechanisms that serve to protect genomic DNA from the oxidative damage, the...

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Akasaka J, Uekuri C, Shigetomi H, et al. Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis. Biomed Rep. 2012;1(1):13-17doi: 10.3892/br.2012.19.
Akasaka, J., Uekuri, C., Shigetomi, H., Koike, M., & Kobayashi, H. (2013). Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis. Biomedical reports, 1(1), 13-17. https://doi.org/10.3892/br.2012.19
Akasaka, Juria, et al. "Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis." Biomedical reports vol. 1,1 (2013): 13-17. doi: https://doi.org/10.3892/br.2012.19
Akasaka J, Uekuri C, Shigetomi H, Koike M, Kobayashi H. Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis. Biomed Rep. 2013 Jan;1(1):13-17. doi: 10.3892/br.2012.19. Epub 2012 Oct 11. PMID: 24648885; PMCID: PMC3956682.
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The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.

iScience

Baranov MV, Bianchi F, Schirmacher A, van Aart MAC, Maassen S, Muntjewerff EM, Dingjan I, Ter Beest M, Verdoes M, Keyser SGL, Bertozzi CR, Diederichsen U, van den Bogaart G.
PMID: 30612035
iScience. 2019 Jan 25;11:160-177. doi: 10.1016/j.isci.2018.12.015. Epub 2018 Dec 20.

Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo/phagosomes into lysosomes by a process called maturation. Maturation is driven by the phosphoinositide kinase PIKfyve. Blocking PIKfyve activity by...

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Baranov MV, Bianchi F, Schirmacher A, et al. The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience. 2018;11:160-177doi: 10.1016/j.isci.2018.12.015.
Baranov, M. V., Bianchi, F., Schirmacher, A., van Aart, M. A. C., Maassen, S., Muntjewerff, E. M., Dingjan, I., Ter Beest, M., Verdoes, M., Keyser, S. G. L., Bertozzi, C. R., Diederichsen, U., & van den Bogaart, G. (2019). The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience, 11160-177. https://doi.org/10.1016/j.isci.2018.12.015
Baranov, Maksim V, et al. "The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation." iScience vol. 11 (2019): 160-177. doi: https://doi.org/10.1016/j.isci.2018.12.015
Baranov MV, Bianchi F, Schirmacher A, van Aart MAC, Maassen S, Muntjewerff EM, Dingjan I, Ter Beest M, Verdoes M, Keyser SGL, Bertozzi CR, Diederichsen U, van den Bogaart G. The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience. 2019 Jan 25;11:160-177. doi: 10.1016/j.isci.2018.12.015. Epub 2018 Dec 20. PMID: 30612035; PMCID: PMC6319320.
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Showing 13 to 24 of 34 entries