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Showing 85 to 88 of 88 entries
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Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling.

Clinical and translational science

Hofmann D, Smit C, Sayasone S, Pfister M, Keiser J.
PMID: 34889057
Clin Transl Sci. 2021 Dec 09; doi: 10.1111/cts.13189. Epub 2021 Dec 09.

Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose of 8 mg is recommended to treat this indication, which shows a reasonably good efficacy and tolerability profile. Yet, owing to the unique life cycle of...

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Hofmann D, Smit C, Sayasone S, et al. Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling. Clin Transl Sci. 2021;doi: 10.1111/cts.13189.
Hofmann, D., Smit, C., Sayasone, S., Pfister, M., & Keiser, J. (2021). Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling. Clinical and translational science, . https://doi.org/10.1111/cts.13189
Hofmann, Daniela, et al. "Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling." Clinical and translational science vol. (2021). doi: https://doi.org/10.1111/cts.13189
Hofmann D, Smit C, Sayasone S, Pfister M, Keiser J. Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling. Clin Transl Sci. 2021 Dec 09; doi: 10.1111/cts.13189. Epub 2021 Dec 09. PMID: 34889057.
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Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Kaji MD, Noonan JD, Geary TG, Beech RN.
PMID: 34749053
Biomed Pharmacother. 2021 Nov 05;145:112380. doi: 10.1016/j.biopha.2021.112380. Epub 2021 Nov 05.

BACKGROUND AND PURPOSE: Nematode glutamate-gated chloride channels (GluCls) are targets of ivermectin (IVM) and moxidectin (MOX), structurally dissimilar macrocyclic lactone (ML) anthelmintics. IVM and MOX possess different pharmacokinetics and efficacy profiles but are thought to have the same binding...

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Kaji MD, Noonan JD, Geary TG, et al. Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2. Biomed Pharmacother. 2021;145:112380doi: 10.1016/j.biopha.2021.112380.
Kaji, M. D., Noonan, J. D., Geary, T. G., & Beech, R. N. (2021). Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 145112380. https://doi.org/10.1016/j.biopha.2021.112380
Kaji, Mark D, et al. "Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 145 (2021): 112380. doi: https://doi.org/10.1016/j.biopha.2021.112380
Kaji MD, Noonan JD, Geary TG, Beech RN. Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2. Biomed Pharmacother. 2021 Nov 05;145:112380. doi: 10.1016/j.biopha.2021.112380. Epub 2021 Nov 05. PMID: 34749053.
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Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses.

Parasites & vectors

Abbas G, Ghafar A, Hurley J, Bauquier J, Beasley A, Wilkes EJA, Jacobson C, El-Hage C, Cudmore L, Carrigan P, Tennent-Brown B, Gauci CG, Nielsen MK, Hughes KJ, Beveridge I, Jabbar A.
PMID: 34863271
Parasit Vectors. 2021 Dec 04;14(1):597. doi: 10.1186/s13071-021-05103-8.

BACKGROUND: Cyathostomins are the most important and common parasitic nematodes of horses, with > 50 species known to occur worldwide. The frequent and indiscriminate use of anthelmintics has resulted in the development of anthelmintic resistance (AR) in horse nematodes....

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Abbas G, Ghafar A, Hurley J, et al. Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasit Vectors. 2021;14(1):597doi: 10.1186/s13071-021-05103-8.
Abbas, G., Ghafar, A., Hurley, J., Bauquier, J., Beasley, A., Wilkes, E. J. A., Jacobson, C., El-Hage, C., Cudmore, L., Carrigan, P., Tennent-Brown, B., Gauci, C. G., Nielsen, M. K., Hughes, K. J., Beveridge, I., & Jabbar, A. (2021). Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasites & vectors, 14(1), 597. https://doi.org/10.1186/s13071-021-05103-8
Abbas, Ghazanfar, et al. "Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses." Parasites & vectors vol. 14,1 (2021): 597. doi: https://doi.org/10.1186/s13071-021-05103-8
Abbas G, Ghafar A, Hurley J, Bauquier J, Beasley A, Wilkes EJA, Jacobson C, El-Hage C, Cudmore L, Carrigan P, Tennent-Brown B, Gauci CG, Nielsen MK, Hughes KJ, Beveridge I, Jabbar A. Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasit Vectors. 2021 Dec 04;14(1):597. doi: 10.1186/s13071-021-05103-8. PMID: 34863271; PMCID: PMC8645149.
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Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease.

International journal for parasitology

Prichard RK.
PMID: 34717929
Int J Parasitol. 2021 Dec;51(13):1121-1132. doi: 10.1016/j.ijpara.2021.08.006. Epub 2021 Oct 27.

Heartworm disease, caused by Dirofilaria immitis, can be lethal in dogs and cats. It is transmitted by mosquitoes, and occurs in many parts of the world. Prevention relies on macrocyclic lactones. Macrocyclic lactones used are ivermectin, selamectin, abamectin, eprinomectin,...

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Prichard RK. Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease. Int J Parasitol. 2021;51(13):1121-1132doi: 10.1016/j.ijpara.2021.08.006.
Prichard, R. K. (2021). Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease. International journal for parasitology, 51(13), 1121-1132. https://doi.org/10.1016/j.ijpara.2021.08.006
Prichard, Roger K. "Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease." International journal for parasitology vol. 51,13 (2021): 1121-1132. doi: https://doi.org/10.1016/j.ijpara.2021.08.006
Prichard RK. Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease. Int J Parasitol. 2021 Dec;51(13):1121-1132. doi: 10.1016/j.ijpara.2021.08.006. Epub 2021 Oct 27. PMID: 34717929.
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Showing 85 to 88 of 88 entries