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Showing 25 to 36 of 144 entries
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TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Arkee T, Hostager BS, Houtman JCD, Bishop GA.
PMID: 34145060
J Immunol. 2021 Jul 01;207(1):322-332. doi: 10.4049/jimmunol.2001220. Epub 2021 Jun 18.

The adaptor protein TNFR-associated factor 3 (TRAF3) is required for in vivo T cell effector functions and for normal TCR/CD28 signaling. TRAF3-mediated enhancement of TCR function requires engagement of both CD3 and CD28, but the molecular mechanisms underlying how...

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Arkee T, Hostager BS, Houtman JCD, et al. TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling. J Immunol. 2021;207(1):322-332doi: 10.4049/jimmunol.2001220.
Arkee, T., Hostager, B. S., Houtman, J. C. D., & Bishop, G. A. (2021). TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling. Journal of immunology (Baltimore, Md. : 1950), 207(1), 322-332. https://doi.org/10.4049/jimmunol.2001220
Arkee, Tina, et al. "TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling." Journal of immunology (Baltimore, Md. : 1950) vol. 207,1 (2021): 322-332. doi: https://doi.org/10.4049/jimmunol.2001220
Arkee T, Hostager BS, Houtman JCD, Bishop GA. TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling. J Immunol. 2021 Jul 01;207(1):322-332. doi: 10.4049/jimmunol.2001220. Epub 2021 Jun 18. PMID: 34145060; PMCID: PMC8683566.
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Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors.

iScience

Vijay S, Gujral TS.
PMID: 32434142
iScience. 2020 May 22;23(5):101129. doi: 10.1016/j.isci.2020.101129. Epub 2020 May 01.

Protein kinase inhibitors are one of the most successful targeted therapies to date. Despite this progress, additional kinase inhibitors are needed to expand the target space as well as overcome drug resistance that has emerged in clinical setting. Here,...

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Vijay S, Gujral TS. Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors. iScience. 2020;23(5):101129doi: 10.1016/j.isci.2020.101129.
Vijay, S., & Gujral, T. S. (2020). Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors. iScience, 23(5), 101129. https://doi.org/10.1016/j.isci.2020.101129
Vijay, Siddharth, and Gujral, Taranjit S. "Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors." iScience vol. 23,5 (2020): 101129. doi: https://doi.org/10.1016/j.isci.2020.101129
Vijay S, Gujral TS. Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors. iScience. 2020 May 22;23(5):101129. doi: 10.1016/j.isci.2020.101129. Epub 2020 May 01. PMID: 32434142; PMCID: PMC7235637.
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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications.

Cancers

Jin W.
PMID: 32456226
Cancers (Basel). 2020 May 23;12(5). doi: 10.3390/cancers12051339.

Src family kinases (SFKs) are non-receptor kinases that play a critical role in the pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are upregulated in patients with CRC. Activation of SFKs promotes CRC cell proliferation, metastases...

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Jin W. Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. Cancers (Basel). 2020;12(5)doi: 10.3390/cancers12051339.
Jin, W. (2020). Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. Cancers, 12(5), . https://doi.org/10.3390/cancers12051339
Jin, Wook. "Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications." Cancers vol. 12,5 (2020). doi: https://doi.org/10.3390/cancers12051339
Jin W. Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. Cancers (Basel). 2020 May 23;12(5). doi: 10.3390/cancers12051339. PMID: 32456226; PMCID: PMC7281431.
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The Src-family Kinase Lyn in Immunoreceptor Signaling.

Endocrinology

Brian BF, Freedman TS.
PMID: 34320188
Endocrinology. 2021 Oct 01;162(10). doi: 10.1210/endocr/bqab152.

Effective regulation of immune-cell activation is critical for ensuring that the immune response, and inflammation generated for the purpose of pathogen elimination, are limited in space and time to minimize tissue damage. Autoimmune disease can occur when immunoreceptor signaling...

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Brian BF, Freedman TS. The Src-family Kinase Lyn in Immunoreceptor Signaling. Endocrinology. 2021;162(10)doi: 10.1210/endocr/bqab152.
Brian, B. F., & Freedman, T. S. (2021). The Src-family Kinase Lyn in Immunoreceptor Signaling. Endocrinology, 162(10), . https://doi.org/10.1210/endocr/bqab152
Brian, Ben F, and Freedman, Tanya S. "The Src-family Kinase Lyn in Immunoreceptor Signaling." Endocrinology vol. 162,10 (2021). doi: https://doi.org/10.1210/endocr/bqab152
Brian BF, Freedman TS. The Src-family Kinase Lyn in Immunoreceptor Signaling. Endocrinology. 2021 Oct 01;162(10). doi: 10.1210/endocr/bqab152. PMID: 34320188; PMCID: PMC8389176.
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Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors.

Oncotarget

Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Bellezza G, Cagini L, Barbareschi M, Ferrero S, Tommasi AM, Aboagye E, Seckl MJ, Pardo OE.
PMID: 29937990
Oncotarget. 2018 Jun 08;9(44):27346-27362. doi: 10.18632/oncotarget.25213. eCollection 2018 Jun 08.

Lung cancer is the main cancer killer in both men and women, mostly due to the rapid development of drug resistant metastatic disease. Here, we evaluate the potential involvement of SRC family kinases (SFK) in lung cancer biology and...

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Rupniewska E, Roy R, Mauri FA, et al. Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors. Oncotarget. 2018;9(44):27346-27362doi: 10.18632/oncotarget.25213.
Rupniewska, E., Roy, R., Mauri, F. A., Liu, X., Kaliszczak, M., Bellezza, G., Cagini, L., Barbareschi, M., Ferrero, S., Tommasi, A. M., Aboagye, E., Seckl, M. J., & Pardo, O. E. (2018). Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors. Oncotarget, 9(44), 27346-27362. https://doi.org/10.18632/oncotarget.25213
Rupniewska, Ewa, et al. "Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors." Oncotarget vol. 9,44 (2018): 27346-27362. doi: https://doi.org/10.18632/oncotarget.25213
Rupniewska E, Roy R, Mauri FA, Liu X, Kaliszczak M, Bellezza G, Cagini L, Barbareschi M, Ferrero S, Tommasi AM, Aboagye E, Seckl MJ, Pardo OE. Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors. Oncotarget. 2018 Jun 08;9(44):27346-27362. doi: 10.18632/oncotarget.25213. eCollection 2018 Jun 08. PMID: 29937990; PMCID: PMC6007948.
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Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors.

Chemical science

Vohidov F, Knudsen SE, Leonard PG, Ohata J, Wheadon MJ, Popp BV, Ladbury JE, Ball ZT.
PMID: 29142714
Chem Sci. 2015 Aug 01;6(8):4778-4783. doi: 10.1039/c5sc01602a. Epub 2015 Jun 03.

Src-family kinases (SFKs) play important roles in human biology and are key drug targets as well. However, achieving selective inhibition of individual Src-family kinases is challenging due to the high similarity within the protein family. We describe rhodium(ii) conjugates...

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Vohidov F, Knudsen SE, Leonard PG, et al. Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors. Chem Sci. 2015;6(8):4778-4783doi: 10.1039/c5sc01602a.
Vohidov, F., Knudsen, S. E., Leonard, P. G., Ohata, J., Wheadon, M. J., Popp, B. V., Ladbury, J. E., & Ball, Z. T. (2015). Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors. Chemical science, 6(8), 4778-4783. https://doi.org/10.1039/c5sc01602a
Vohidov, Farrukh, et al. "Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors." Chemical science vol. 6,8 (2015): 4778-4783. doi: https://doi.org/10.1039/c5sc01602a
Vohidov F, Knudsen SE, Leonard PG, Ohata J, Wheadon MJ, Popp BV, Ladbury JE, Ball ZT. Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors. Chem Sci. 2015 Aug 01;6(8):4778-4783. doi: 10.1039/c5sc01602a. Epub 2015 Jun 03. PMID: 29142714; PMCID: PMC5667506.
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Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis.

Molecular and cellular biology

Imada S, Murata Y, Kotani T, Hatano M, Sun C, Konno T, Park JH, Kitamura Y, Saito Y, Ohdan H, Matozaki T.
PMID: 27550814
Mol Cell Biol. 2016 Oct 28;36(22):2811-2823. doi: 10.1128/MCB.00311-16. Print 2016 Nov 15.

Proper regulation of epithelial cell turnover is important for the structural integrity and homeostasis of various tissues, including the intestine. Here we show that ablation of Csk, a negative regulator of Src family kinases (SFKs), specifically in intestinal epithelial...

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Imada S, Murata Y, Kotani T, et al. Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis. Mol Cell Biol. 2016;36(22):2811-2823doi: 10.1128/MCB.00311-16.
Imada, S., Murata, Y., Kotani, T., Hatano, M., Sun, C., Konno, T., Park, J. H., Kitamura, Y., Saito, Y., Ohdan, H., & Matozaki, T. (2016). Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis. Molecular and cellular biology, 36(22), 2811-2823. https://doi.org/10.1128/MCB.00311-16
Imada, Shinya, et al. "Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis." Molecular and cellular biology vol. 36,22 (2016): 2811-2823. doi: https://doi.org/10.1128/MCB.00311-16
Imada S, Murata Y, Kotani T, Hatano M, Sun C, Konno T, Park JH, Kitamura Y, Saito Y, Ohdan H, Matozaki T. Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis. Mol Cell Biol. 2016 Oct 28;36(22):2811-2823. doi: 10.1128/MCB.00311-16. Print 2016 Nov 15. PMID: 27550814; PMCID: PMC5086522.
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Regulation of SRC family kinases in human cancers.

Journal of signal transduction

Sen B, Johnson FM.
PMID: 21776389
J Signal Transduct. 2011;2011:865819. doi: 10.1155/2011/865819. Epub 2011 Apr 04.

The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells. Although the Src family kinases (SFKs) are activated in various...

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Sen B, Johnson FM. Regulation of SRC family kinases in human cancers. J Signal Transduct. 2011;2011:865819doi: 10.1155/2011/865819.
Sen, B., & Johnson, F. M. (2011). Regulation of SRC family kinases in human cancers. Journal of signal transduction, 2011865819. https://doi.org/10.1155/2011/865819
Sen, Banibrata, and Johnson, Faye M. "Regulation of SRC family kinases in human cancers." Journal of signal transduction vol. 2011 (2011): 865819. doi: https://doi.org/10.1155/2011/865819
Sen B, Johnson FM. Regulation of SRC family kinases in human cancers. J Signal Transduct. 2011;2011:865819. doi: 10.1155/2011/865819. Epub 2011 Apr 04. PMID: 21776389; PMCID: PMC3135246.
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A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways.

American journal of translational research

She EX, Hao Z.
PMID: 24093059
Am J Transl Res. 2013 Sep 25;5(6):622-33. eCollection 2013.

Despite rapid progress in anticancer drug development and improvement in clinical outcomes, the survival rate for many types of cancer is still unacceptably low. Therefore, it is crucial to discover novel anticancer drugs to both prevent and treat the...

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She EX, Hao Z. A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. Am J Transl Res. 2013;5(6):622-33
She, E. X., & Hao, Z. (2013). A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. American journal of translational research, 5(6), 622-33.
She, Edward X, and Hao, Zhonglin. "A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways." American journal of translational research vol. 5,6 (2013): 622-33.
She EX, Hao Z. A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. Am J Transl Res. 2013 Sep 25;5(6):622-33. eCollection 2013. PMID: 24093059; PMCID: PMC3786269.
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Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line.

Cancer research and treatment

Yoon SG, Cheong HJ, Kim SJ, Kim KH, Lee SC, Lee N, Park HS, Won JH.
PMID: 23864846
Cancer Res Treat. 2013 Jun;45(2):126-33. doi: 10.4143/crt.2013.45.2.126. Epub 2013 Jun 30.

PURPOSE: Leukemic promyelocytes have the unique ability to undergo differentiation after exposure to retinoic acid and both differentiation and apoptosis after exposure to arsenic trioxide (ATO). Recent studies have shown that inhibition of Src family kinases (SFKs) resulted in...

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Yoon SG, Cheong HJ, Kim SJ, et al. Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat. 2013;45(2):126-33doi: 10.4143/crt.2013.45.2.126.
Yoon, S. G., Cheong, H. J., Kim, S. J., Kim, K. H., Lee, S. C., Lee, N., Park, H. S., & Won, J. H. (2013). Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer research and treatment, 45(2), 126-33. https://doi.org/10.4143/crt.2013.45.2.126
Yoon, Suk-Gu, et al. "Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line." Cancer research and treatment vol. 45,2 (2013): 126-33. doi: https://doi.org/10.4143/crt.2013.45.2.126
Yoon SG, Cheong HJ, Kim SJ, Kim KH, Lee SC, Lee N, Park HS, Won JH. Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat. 2013 Jun;45(2):126-33. doi: 10.4143/crt.2013.45.2.126. Epub 2013 Jun 30. PMID: 23864846; PMCID: PMC3710962.
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Adaptive metabolic rewiring to chronic SFK inhibition.

Oncotarget

Pinedo-Carpio E, Davidson D, Martinez Marignac VL, Panasci J, Aloyz R.
PMID: 28977994
Oncotarget. 2016 Mar 17;8(40):66758-66768. doi: 10.18632/oncotarget.8146. eCollection 2017 Sep 15.

Src family kinases (SFK) are key regulators of cellular proliferation, differentiation, survival, motility and angiogenesis. As such, SFK inhibitors are being tested in clinical trials to prevent metastasis as an alternative to current treatment regimens for a variety of...

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Pinedo-Carpio E, Davidson D, Martinez Marignac VL, et al. Adaptive metabolic rewiring to chronic SFK inhibition. Oncotarget. 2016;8(40):66758-66768doi: 10.18632/oncotarget.8146.
Pinedo-Carpio, E., Davidson, D., Martinez Marignac, V. L., Panasci, J., & Aloyz, R. (2017). Adaptive metabolic rewiring to chronic SFK inhibition. Oncotarget, 8(40), 66758-66768. https://doi.org/10.18632/oncotarget.8146
Pinedo-Carpio, Edgar, et al. "Adaptive metabolic rewiring to chronic SFK inhibition." Oncotarget vol. 8,40 (2017): 66758-66768. doi: https://doi.org/10.18632/oncotarget.8146
Pinedo-Carpio E, Davidson D, Martinez Marignac VL, Panasci J, Aloyz R. Adaptive metabolic rewiring to chronic SFK inhibition. Oncotarget. 2016 Mar 17;8(40):66758-66768. doi: 10.18632/oncotarget.8146. eCollection 2017 Sep 15. PMID: 28977994; PMCID: PMC5620134.
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Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation.

Cancer cell international

Iriyama N, Yuan B, Hatta Y, Takagi N, Takei M.
PMID: 27182202
Cancer Cell Int. 2016 May 13;16:37. doi: 10.1186/s12935-016-0314-5. eCollection 2016.

BACKGROUND: Lyn, an import member of Src family kinases (SFKs), is supposed to be implicated in acute myeloid leukemia (AML) pathogenesis and development by participation in AML differentiation, yet the details still remain incompletely understood. The expression status of...

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Iriyama N, Yuan B, Hatta Y, et al. Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation. Cancer Cell Int. 2016;16:37doi: 10.1186/s12935-016-0314-5.
Iriyama, N., Yuan, B., Hatta, Y., Takagi, N., & Takei, M. (2016). Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation. Cancer cell international, 1637. https://doi.org/10.1186/s12935-016-0314-5
Iriyama, Noriyoshi, et al. "Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation." Cancer cell international vol. 16 (2016): 37. doi: https://doi.org/10.1186/s12935-016-0314-5
Iriyama N, Yuan B, Hatta Y, Takagi N, Takei M. Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation. Cancer Cell Int. 2016 May 13;16:37. doi: 10.1186/s12935-016-0314-5. eCollection 2016. PMID: 27182202; PMCID: PMC4866426.
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Showing 25 to 36 of 144 entries