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Showing 145 to 149 of 149 entries
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Pathergy test with a 23G needle with and without self-saliva in patients with Behçet's disease, recurrent aphthous stomatitis and control group compared to the 20G test.

Reumatologia

Shenavandeh S, Sadeghi SMK, Aflaki E.
PMID: 34819704
Reumatologia. 2021;59(5):302-308. doi: 10.5114/reum.2021.110567. Epub 2021 Nov 01.

OBJECTIVES: The pathergy test (PT) is part of the diagnostic criteria of Behçet's disease (BD). Factors like needle character and number of punctures can affect the sensitivity of PT. We tried to compare its positivity using a thinner needle...

A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals.

Nature genetics

Holoch D, Wassef M, Lövkvist C, Zielinski D, Aflaki S, Lombard B, Héry T, Loew D, Howard M, Margueron R.
PMID: 34782763
Nat Genet. 2021 Dec;53(12):1686-1697. doi: 10.1038/s41588-021-00964-2. Epub 2021 Nov 15.

Epigenetic inheritance of gene expression states enables a single genome to maintain distinct cellular identities. How histone modifications contribute to this process remains unclear. Using global chromatin perturbations and local, time-controlled modulation of transcription, we establish the existence of...

A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals.

Nature genetics

Holoch D, Wassef M, Lövkvist C, Zielinski D, Aflaki S, Lombard B, Héry T, Loew D, Howard M, Margueron R.
PMID: 34782763
Nat Genet. 2021 Dec;53(12):1686-1697. doi: 10.1038/s41588-021-00964-2. Epub 2021 Nov 15.

Epigenetic inheritance of gene expression states enables a single genome to maintain distinct cellular identities. How histone modifications contribute to this process remains unclear. Using global chromatin perturbations and local, time-controlled modulation of transcription, we establish the existence of...

Efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes: A post hoc subgroup analysis of the PIONEER 1, 3, 4 and 8 trials.

Diabetes, obesity & metabolism

Araki E, Terauchi Y, Watada H, Deenadayalan S, Christiansen E, Horio H, Kadowaki T.
PMID: 34472698
Diabetes Obes Metab. 2021 Dec;23(12):2785-2794. doi: 10.1111/dom.14536. Epub 2021 Sep 27.

AIMS: To evaluate, through exploratory post hoc subgroup analyses, the efficacy and safety of oral semaglutide versus comparators in Japanese patients enrolled in the global PIONEER 1, 3, 4 and 8 clinical trials.MATERIALS AND METHODS: Patients were randomized to...

Experimental exchange of paralogous domains in the MLH family provides evidence of sub-functionalization after gene duplication.

G3 (Bethesda, Md.)

Furman CM, Elbashir R, Pannafino G, Clark NL, Alani E.
PMID: 33871573
G3 (Bethesda). 2021 Apr 19; doi: 10.1093/g3journal/jkab111. Epub 2021 Apr 19.

Baker's yeast contains a large number of duplicated genes; some function redundantly, whereas others have more specialized roles. We used the MLH family of DNA mismatch repair proteins as a model to better understand the steps that lead to...

Showing 145 to 149 of 149 entries