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Showing 13 to 24 of 47 entries
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Human influenza virus challenge identifies cellular correlates of protection for oral vaccination.

Cell host & microbe

McIlwain DR, Chen H, Rahil Z, Bidoki NH, Jiang S, Bjornson Z, Kolhatkar NS, Martinez CJ, Gaudillière B, Hedou J, Mukherjee N, Schürch CM, Trejo A, Affrime M, Bock B, Kim K, Liebowitz D, Aghaeepour N, Tucker SN, Nolan GP.
PMID: 34784508
Cell Host Microbe. 2021 Dec 08;29(12):1828-1837.e5. doi: 10.1016/j.chom.2021.10.009. Epub 2021 Nov 15.

Developing new influenza vaccines with improved performance and easier administration routes hinges on defining correlates of protection. Vaccine-elicited cellular correlates of protection for influenza in humans have not yet been demonstrated. A phase-2 double-blind randomized placebo and active (inactivated...

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.

Nature reviews. Neurology

Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I, Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA.
PMID: 32541893
Nat Rev Neurol. 2020 Jul;16(7):381-400. doi: 10.1038/s41582-020-0362-2. Epub 2020 Jun 15.

Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-related overdose deaths. The...

SESSION INTRODUCTION.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

Samusik N, Aghaeepour N, Bendall S.
PMID: 27897006
Pac Symp Biocomput. 2017;22:557-563. doi: 10.1142/9789813207813_0051.

Recent technological developments allow gathering single-cell measurements across different domains (genomic, transcriptomics, proteomics, imaging etc). Sophisticated computational algorithms are required in order to harness the power of single-cell data. This session is dedicated to computational methods for single-cell analysis...

Towards personalized medicine in maternal and child health: integrating biologic and social determinants.

Pediatric research

Stevenson DK, Wong RJ, Aghaeepour N, Maric I, Angst MS, Contrepois K, Darmstadt GL, Druzin ML, Eisenberg ML, Gaudilliere B, Gibbs RS, Gotlib IH, Gould JB, Lee HC, Ling XB, Mayo JA, Moufarrej MN, Quaintance CC, Quake SR, Relman DA, Sirota M, Snyder MP, Sylvester KG, Hao S, Wise PH, Shaw GM, Katz M.
PMID: 32454518
Pediatr Res. 2021 Jan;89(2):252-258. doi: 10.1038/s41390-020-0981-8. Epub 2020 May 26.

No abstract available.

Human influenza virus challenge identifies cellular correlates of protection for oral vaccination.

Cell host & microbe

McIlwain DR, Chen H, Rahil Z, Bidoki NH, Jiang S, Bjornson Z, Kolhatkar NS, Martinez CJ, Gaudillière B, Hedou J, Mukherjee N, Schürch CM, Trejo A, Affrime M, Bock B, Kim K, Liebowitz D, Aghaeepour N, Tucker SN, Nolan GP.
PMID: 34784508
Cell Host Microbe. 2021 Dec 08;29(12):1828-1837.e5. doi: 10.1016/j.chom.2021.10.009. Epub 2021 Nov 15.

Developing new influenza vaccines with improved performance and easier administration routes hinges on defining correlates of protection. Vaccine-elicited cellular correlates of protection for influenza in humans have not yet been demonstrated. A phase-2 double-blind randomized placebo and active (inactivated...

Data-Driven Modeling of Pregnancy-Related Complications.

Trends in molecular medicine

Espinosa C, Becker M, Marić I, Wong RJ, Shaw GM, Gaudilliere B, Aghaeepour N, Stevenson DK.
PMID: 33573911
Trends Mol Med. 2021 Aug;27(8):762-776. doi: 10.1016/j.molmed.2021.01.007. Epub 2021 Feb 08.

A healthy pregnancy depends on complex interrelated biological adaptations involving placentation, maternal immune responses, and hormonal homeostasis. Recent advances in high-throughput technologies have provided access to multiomics biological data that, combined with clinical and social data, can provide a...

Black swans and ambitious overgeneralization in newborn intensive care.

Pediatric research

Stevenson DK, Wong RJ, Shaw GM, Aghaeepour N, Maric I, Prince LS, Reiss JD, Katz M.
PMID: 34601493
Pediatr Res. 2021 Oct 02; doi: 10.1038/s41390-021-01771-5. Epub 2021 Oct 02.

No abstract available.

Optical response of wurtzite and zinc blende GaP nanowire arrays.

Optics express

Aghaeipour M, Anttu N, Nylund G, Berg A, Lehmann S, Pistol ME.
PMID: 26698498
Opt Express. 2015 Nov 16;23(23):30177-87. doi: 10.1364/OE.23.030177.

We compare the optical response of wurtzite and zinc blende GaP nanowire arrays for varying geometry of the nanowires. We measure reflectance spectra of the arrays and extract from these measurements the absorption in the nanowires. To support our...

Optimization of Recombinant Expression of Synthetic Bacterial Phytase in Pichia pastoris Using Response Surface Methodology.

Jundishapur journal of microbiology

Akbarzadeh A, Dehnavi E, Aghaeepoor M, Amani J.
PMID: 26870311
Jundishapur J Microbiol. 2015 Dec 26;8(12):e27553. doi: 10.5812/jjm.27553. eCollection 2015 Dec.

BACKGROUND: Escherichia coli phytase is an acidic histidine phytase with great specific activity. Pichia pastoris is a powerful system for the heterologous expression of active and soluble proteins which can express recombinant proteins in high cell density fermenter without...

Bias-dependent spectral tuning in InP nanowire-based photodetectors.

Nanotechnology

Jain V, Heurlin M, Karimi M, Hussain L, Aghaeipour M, Nowzari A, Berg A, Nylund G, Capasso F, Samuelson L, Borgström MT, Pettersson H.
PMID: 28211361
Nanotechnology. 2017 Mar 17;28(11):114006. doi: 10.1088/1361-6528/aa5236.

Nanowire array ensembles contacted in a vertical geometry are extensively studied and considered strong candidates for next generations of industrial scale optoelectronics. Key challenges in this development deal with optimization of the doping profile of the nanowires and the...

Anti-Stokes photoluminescence probing k-conservation and thermalization of minority carriers in degenerately doped semiconductors.

Nature communications

Mergenthaler K, Anttu N, Vainorius N, Aghaeipour M, Lehmann S, Borgström MT, Samuelson L, Pistol ME.
PMID: 29158511
Nat Commun. 2017 Nov 21;8(1):1634. doi: 10.1038/s41467-017-01817-5.

It has recently been found that anti-Stokes photoluminescence can be observed in degenerately n-doped indium phosphide nanowires, when exciting directly into the electron gas. This anti-Stokes mechanism has not been observed before and allows the study of carrier relaxation...

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy.

Bioinformatics (Oxford, England)

Ghaemi MS, DiGiulio DB, Contrepois K, Callahan B, Ngo TTM, Lee-McMullen B, Lehallier B, Robaczewska A, Mcilwain D, Rosenberg-Hasson Y, Wong RJ, Quaintance C, Culos A, Stanley N, Tanada A, Tsai A, Gaudilliere D, Ganio E, Han X, Ando K, McNeil L, Tingle M, Wise P, Maric I, Sirota M, Wyss-Coray T, Winn VD, Druzin ML, Gibbs R, Darmstadt GL, Lewis DB, Partovi Nia V, Agard B, Tibshirani R, Nolan G, Snyder MP, Relman DA, Quake SR, Shaw GM, Stevenson DK, Angst MS, Gaudilliere B, Aghaeepour N.
PMID: 30561547
Bioinformatics. 2019 Jan 01;35(1):95-103. doi: 10.1093/bioinformatics/bty537.

MOTIVATION: Multiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy. Modeling the chronology of these adaptations during full-term pregnancy provides the frameworks for future studies...

Showing 13 to 24 of 47 entries