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Showing 37 to 47 of 47 entries
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The Expression and Prognostic Impact of CD95 Death Receptor and CD20, CD34 and CD44 Differentiation Markers in Pediatric Acute Lymphoblastic Leukemia.

Iranian journal of pediatrics

M Kamazani F, Bahoush-Mehdiabadi G, Aghaeipour M, Vaeli S, Amirghofran Z.
PMID: 25755857
Iran J Pediatr. 2014 Aug;24(4):371-80. Epub 2014 May 21.

OBJECTIVE: This study investigated the expression and prognostic significance of the CD95 death receptor and CD20, a B cell-lineage associated marker, along with CD34 and CD44 non-lineage associated molecules in Iranian children with acute lymphoblastic leukemia (ALL).METHODS: We performed...

Optimization and High Level Production of Recombinant Synthetic Streptokinase in .

Iranian journal of pharmaceutical research : IJPR

Aghaeepoor M, Akbarzadeh A, Kobarfard F, Shabani AA, Dehnavi E, Jamshidi Aval S, Akbari Eidgahi MR.
PMID: 31531077
Iran J Pharm Res. 2019;18(2):961-973. doi: 10.22037/ijpr.2019.1100636.

Streptokinase (SK) is an extracellular protein comprising 414 amino acids with considerable clinical importance as a commonly used thrombolytic agent. Due to its wide spread application and clinical importance designing more efficient SK production platforms worth investigation. In this...

Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum.

Frontiers in immunology

Peterson LS, Hedou J, Ganio EA, Stelzer IA, Feyaerts D, Harbert E, Adusumelli Y, Ando K, Tsai ES, Tsai AS, Han X, Ringle M, Houghteling P, Reiss JD, Lewis DB, Winn VD, Angst MS, Aghaeepour N, Stevenson DK, Gaudilliere B.
PMID: 34497610
Front Immunol. 2021 Aug 23;12:714090. doi: 10.3389/fimmu.2021.714090. eCollection 2021.

Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at birth across the spectrum of...

Single-cell peripheral immunoprofiling of Alzheimer's and Parkinson's diseases.

Science advances

Phongpreecha T, Fernandez R, Mrdjen D, Culos A, Gajera CR, Wawro AM, Stanley N, Gaudilliere B, Poston KL, Aghaeepour N, Montine TJ.
PMID: 33239300
Sci Adv. 2020 Nov 25;6(48). doi: 10.1126/sciadv.abd5575. Print 2020 Nov.

Peripheral blood mononuclear cells (PBMCs) may provide insight into the pathogenesis of Alzheimer's disease (AD) or Parkinson's disease (PD). We investigated PBMC samples from 132 well-characterized research participants using seven canonical immune stimulants, mass cytometric identification of 35 PBMC...

Towards personalized medicine in maternal and child health: integrating biologic and social determinants.

Pediatric research

Stevenson DK, Wong RJ, Aghaeepour N, Maric I, Angst MS, Contrepois K, Darmstadt GL, Druzin ML, Eisenberg ML, Gaudilliere B, Gibbs RS, Gotlib IH, Gould JB, Lee HC, Ling XB, Mayo JA, Moufarrej MN, Quaintance CC, Quake SR, Relman DA, Sirota M, Snyder MP, Sylvester KG, Hao S, Wise PH, Shaw GM, Katz M.
PMID: 32454518
Pediatr Res. 2021 Jan;89(2):252-258. doi: 10.1038/s41390-020-0981-8. Epub 2020 May 26.

No abstract available.

Newborn screen metabolic panels reflect the impact of common disorders of pregnancy.

Pediatric research

Reiss JD, Chang AL, Mayo JA, Bianco K, Lee HC, Stevenson DK, Shaw GM, Aghaeepour N, Sylvester KG.
PMID: 34671094
Pediatr Res. 2021 Oct 20; doi: 10.1038/s41390-021-01753-7. Epub 2021 Oct 20.

BACKGROUND: Hypertensive disorders of pregnancy and maternal diabetes profoundly affect fetal and newborn growth, yet disturbances in intermediate metabolism and relevant mediators of fetal growth alterations remain poorly defined. We sought to determine whether there are distinct newborn screen...

In Reply.

Anesthesiology

Angst MS, Fragiadakis GK, Gaudillière B, Aghaeepour N, Nolan GP.
PMID: 27187126
Anesthesiology. 2016 Jun;124(6):1414-5. doi: 10.1097/ALN.0000000000001091.

No abstract available.

Human influenza virus challenge identifies cellular correlates of protection for oral vaccination.

Cell host & microbe

McIlwain DR, Chen H, Rahil Z, Bidoki NH, Jiang S, Bjornson Z, Kolhatkar NS, Martinez CJ, Gaudillière B, Hedou J, Mukherjee N, Schürch CM, Trejo A, Affrime M, Bock B, Kim K, Liebowitz D, Aghaeepour N, Tucker SN, Nolan GP.
PMID: 34784508
Cell Host Microbe. 2021 Dec 08;29(12):1828-1837.e5. doi: 10.1016/j.chom.2021.10.009. Epub 2021 Nov 15.

Developing new influenza vaccines with improved performance and easier administration routes hinges on defining correlates of protection. Vaccine-elicited cellular correlates of protection for influenza in humans have not yet been demonstrated. A phase-2 double-blind randomized placebo and active (inactivated...

Deleterious and Protective Psychosocial and Stress-Related Factors Predict Risk of Spontaneous Preterm Birth.

American journal of perinatology

Becker M, Mayo JA, Phogat NK, Quaintance CC, Laborde A, King L, Gotlib IH, Gaudilliere B, Angst MS, Shaw GM, Stevenson DK, Aghaeepour N, Dhabhar FS.
PMID: 34015838
Am J Perinatol. 2021 May 20; doi: 10.1055/s-0041-1729162. Epub 2021 May 20.

OBJECTIVES:  The aim of the study was to: (1) Identify (early in pregnancy) psychosocial and stress-related factors that predict risk of spontaneous preterm birth (PTB, gestational age

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19.

bioRxiv : the preprint server for biology

Feyaerts D, Hedou J, Gillard J, Chen H, Tsai ES, Peterson LS, Ando K, Manohar M, Do E, Dhondalay GKR, Fitzpatrick J, Artandi M, Chang I, Snow TT, Chinthrajah RS, Warren CM, Wittman R, Meyerowitz JG, Ganio EA, Stelzer IA, Han X, Verdonk F, Gaudilliere DK, Mukherjee N, Tsai AS, Rumer KK, Jiang SJ, Valdes-Ferrer SI, Kelly JD, Furman D, Aghaeepour N, Angst MS, Boyd SD, Pinsky BA, Nolan GP, Nadeau KC, Gaudilliere B, McIlwain DR.
PMID: 33594362
bioRxiv. 2021 Feb 10; doi: 10.1101/2021.02.09.430269.

The biological determinants of the wide spectrum of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, basal signaling activity, and signaling responses to inflammatory ligands were assessed...

Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts - implications for clinical biomarker studies.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Ghaemi MS, Tarca AL, Romero R, Stanley N, Fallahzadeh R, Tanada A, Culos A, Ando K, Han X, Blumenfeld YJ, Druzin ML, El-Sayed YY, Gibbs RS, Winn VD, Contrepois K, Ling XB, Wong RJ, Shaw GM, Stevenson DK, Gaudilliere B, Aghaeepour N, Angst MS.
PMID: 33653202
J Matern Fetal Neonatal Med. 2021 Mar 02;1-8. doi: 10.1080/14767058.2021.1888915. Epub 2021 Mar 02.

BACKGROUND: Early identification of pregnant women at risk for preeclampsia (PE) is important, as it will enable targeted interventions ahead of clinical manifestations. The quantitative analyses of plasma proteins feature prominently among molecular approaches used for risk prediction. However,...

Showing 37 to 47 of 47 entries