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Showing 121 to 127 of 127 entries
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The Contribution of Dysfunctional Chloride Channels to Neurovascular Deficiency and Neurodegeneration.

Frontiers in pharmacology

Gascoigne DA, Drobyshevsky A, Aksenov DP.
PMID: 34671264
Front Pharmacol. 2021 Oct 04;12:754743. doi: 10.3389/fphar.2021.754743. eCollection 2021.

No abstract available.

A community resource for paired genomic and metabolomic data mining.

Nature chemical biology

Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ.
PMID: 33589842
Nat Chem Biol. 2021 Apr;17(4):363-368. doi: 10.1038/s41589-020-00724-z.

No abstract available.

Synthesis of (2-chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides.

Russian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia

Aksenov AN, Krayushkin MM, Yarovenko VN.
PMID: 34305379
Russ Chem Bull. 2021;70(6):1131-1134. doi: 10.1007/s11172-021-3194-3. Epub 2021 Jul 14.

(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained

A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases.

Journal of pharmacokinetics and pharmacodynamics

Leander J, Sunnåker M, Rekić D, Aksenov S, Eriksson UG, Johansson S, Parkinson J.
PMID: 33728547
J Pharmacokinet Pharmacodyn. 2021 Aug;48(4):525-541. doi: 10.1007/s10928-021-09747-y. Epub 2021 Mar 17.

Verinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of...

Machine Learning for Urodynamic Detection of Detrusor Overactivity.

Urology

Hobbs KT, Choe N, Aksenov LI, Reyes L, Aquino W, Routh JC, Hokanson JA.
PMID: 34757048
Urology. 2021 Oct 29; doi: 10.1016/j.urology.2021.09.027. Epub 2021 Oct 29.

OBJECTIVE: To develop a machine learning algorithm that identifies detrusor overactivity (DO) in Urodynamic Studies (UDS) in the spina bifida population. UDS plays a key role in assessment of neurogenic bladder in patients with spina bifida. Due to significant...

Reply to: Examining microbe-metabolite correlations by linear methods.

Nature methods

Morton JT, McDonald D, Aksenov AA, Nothias LF, Foulds JR, Quinn RA, Badri MH, Swenson TL, Van Goethem MW, Northen TR, Vazquez-Baeza Y, Wang M, Bokulich NA, Watters A, Song SJ, Bonneau R, Dorrestein PC, Knight R.
PMID: 33398188
Nat Methods. 2021 Jan;18(1):40-41. doi: 10.1038/s41592-020-01007-0. Epub 2021 Jan 04.

No abstract available.

Influence of acetic acid on the photocatalytic activity of photosensitiser-amphiphilic polymer complexes in the oxidation reaction of tryptophan.

The Journal of chemical physics

Kardumyan VV, Aksenova NA, Glagolev NN, Timashev PS, Solovieva AB.
PMID: 33687255
J Chem Phys. 2020 May 21;152(19):194901. doi: 10.1063/5.0007362.

The effect of acetic acid on the photosensitizing activity of dimegin (DMG), chlorin e6 (Ce6), and their complexes with amphiphilic polymers-Pluronic F-127 and poly-N-vinylpyrrolidone (PVP)-in the model reaction of tryptophan photo-oxidation has been established. It was shown that the...

Showing 121 to 127 of 127 entries