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Showing 13 to 24 of 269 entries
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Blurring contact maps of thousands of proteins: what we can learn by reconstructing 3D structure.

BioData mining

Vassura M, Di Lena P, Margara L, Mirto M, Aloisio G, Fariselli P, Casadio R.
PMID: 21232136
BioData Min. 2011 Jan 13;4(1):1. doi: 10.1186/1756-0381-4-1.

BACKGROUND: The present knowledge of protein structures at atomic level derives from some 60,000 molecules. Yet the exponential ever growing set of hypothetical protein sequences comprises some 10 million chains and this makes the problem of protein structure prediction...

Velocity matching by pulse front tilting for large area THz-pulse generation.

Optics express

Hebling J, Almasi G, Kozma I, Kuhl J.
PMID: 19451975
Opt Express. 2002 Oct 21;10(21):1161-6. doi: 10.1364/oe.10.001161.

We propose a generally applicable velocity matching method for THz-pulse generation by optical rectification in the range below the phonon frequency of the nonlinear material. Velocity matching is based on pulse front tilting of the ultrashort excitation pulse and...

Biological functions of histidine-dipeptides and metabolic syndrome.

Nutrition research and practice

Song BC, Joo NS, Aldini G, Yeum KJ.
PMID: 24611099
Nutr Res Pract. 2014 Feb;8(1):3-10. doi: 10.4162/nrp.2014.8.1.3. Epub 2014 Jan 29.

The rapid increase in the prevalence of metabolic syndrome, which is associated with a state of elevated systemic oxidative stress and inflammation, is expected to cause future increases in the prevalence of diabetes and cardiovascular diseases. Oxidation of polyunsaturated...

Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent findings.

Translational gastrointestinal cancer

Hodges K, Kennedy L, Meng F, Alpini G, Francis H.
PMID: 22943044
Transl Gastrointest Cancer. 2012 Jul 01;1(2):138-150. Epub 2012 Feb 08.

Paul Ehrlich, a German scientist, discovered what is known as the mast cell in the late 1800's, which has proven to be an important player in the immune system of vertebrates. Mast cells are ubiquitous throughout the tissues of...

Looking for A Place for Dose-Dense TMZ Regimens in GBM Patients: An Experience with MGMT Exploratory Evaluation.

Bioengineering (Basel, Switzerland)

Napoleoni L, Cortellini A, Cannita K, Parisi A, Dal Mas A, Calvisi G, Venditti O, Baldi PL, Cocciolone V, Ricci A, Ficorella C.
PMID: 30678211
Bioengineering (Basel). 2019 Jan 22;6(1). doi: 10.3390/bioengineering6010011.

Prolonged exposure to temozolomide (TMZ) could improve clinical outcomes in recurrent glioblastoma multiforme (GBM) patients. We previously developed a dose-dense regimen of TMZ in a phase II study (180 mg/m2 from days 1 to 5 every two weeks). A...

Numerical investigation of a scalable setup for efficient terahertz generation using a segmented tilted-pulse-front excitation.

Optics express

Pálfalvi L, Tóth G, Tokodi L, Márton Z, Fülöp JA, Almási G, Hebling J.
PMID: 29220994
Opt Express. 2017 Nov 27;25(24):29560-29573. doi: 10.1364/OE.25.029560.

A hybrid-type terahertz pulse source is proposed for high energy terahertz pulse generation. It is the combination of the conventional tilted-pulse-front setup and a transmission stair-step echelon-faced nonlinear crystal with a period falling in the hundred-micrometer range. The most...

Bile acid signaling and biliary functions.

Acta pharmaceutica Sinica. B

Jones H, Alpini G, Francis H.
PMID: 26579437
Acta Pharm Sin B. 2015 Mar;5(2):123-8. doi: 10.1016/j.apsb.2015.01.009. Epub 2015 Feb 19.

This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes...

Systemic sclerosis associated with colliquative necrosis in the cerebellum.

Surgical neurology international

Ricci A, Di Vitantonio H, De Paulis D, Del Maestro M, Dehcordi SR, Murrone D, Coletti G, Calvisi G, Galzio RJ.
PMID: 28480106
Surg Neurol Int. 2017 Apr 05;8:44. doi: 10.4103/sni.sni_401_16. eCollection 2017.

BACKGROUND: The scleroderma is a complex autoimmune collagen disorder that can affect many organs simultaneously, as it occurs in the systemic sclerosis (SS), or only the skin, as it occurs in the localized scleroderma (LS). The neurological presentation is...

Spermine Regulates Pollen Tube Growth by Modulating Ca.

Frontiers in plant science

Aloisi I, Cai G, Faleri C, Navazio L, Serafini-Fracassini D, Del Duca S.
PMID: 29033970
Front Plant Sci. 2017 Sep 29;8:1701. doi: 10.3389/fpls.2017.01701. eCollection 2017.

Proper growth of the pollen tube depends on an elaborate mechanism that integrates several molecular and cytological sub-processes and ensures a cell shape adapted to the transport of gametes. This growth mechanism is controlled by several molecules among which...

Mass Spectrometry-based Label-free Quantitative Proteomics To Study the Effect of 3PO Drug at Cellular Level.

ACS medicinal chemistry letters

Nukala SB, Baron G, Aldini G, Carini M, D'Amato A.
PMID: 30996799
ACS Med Chem Lett. 2019 Jan 11;10(4):577-583. doi: 10.1021/acsmedchemlett.8b00593. eCollection 2019 Apr 11.

Human endothelial cells (ECs) have been employed to monitor the protein changes induced by [3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one] (3PO), a compound able to inhibit the glycolytic flux partially and transiently and to reduce pathological angiogenesis in a variety of disease models. Normal...

The role of cardiovascular ultrasound in diagnosis and management of pulmonary embolism.

Future cardiology

Esposito R, Santoro C, Sorrentino R, Alcidi G, De Roberto AM, Santoro A, Tufano A, Trimarco B, Galderisi M.
PMID: 28832194
Future Cardiol. 2017 Sep;13(5):465-477. doi: 10.2217/fca-2017-0037. Epub 2017 Aug 23.

The diagnosis of acute pulmonary embolism (PE) is one of the most important problems in medical emergencies. Commonly accepted criterion for diagnosis of deep venous thrombosis is the lack of vein compressibility assessed by Compression UltraSonography. Echocardiography represents an...

In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism.

Antioxidants (Basel, Switzerland)

Petkovic I, Bresgen N, Gilardoni E, Regazzoni L, Uchida K, Aldini G, Siems W, Eckl P.
PMID: 32053996
Antioxidants (Basel). 2020 Feb 11;9(2). doi: 10.3390/antiox9020150.

Evidence suggests that the increased production of free radicals and reactive oxygen species lead to cellular aging. One of the consequences is lipid peroxidation generating reactive aldehydic products, such as 4-hydroxynonenal (HNE) that modify proteins and form adducts with...

Showing 13 to 24 of 269 entries