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Showing 25 to 36 of 394 entries
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Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides.

Chemistry, an Asian journal

Narlawar R, Austin CJD, Kahlert J, Selleri S, Da Pozzo E, Martini C, Werry EL, Rendina LM, Kassiou M.
PMID: 30369074
Chem Asian J. 2018 Nov 02;13(21):3321-3327. doi: 10.1002/asia.201801175. Epub 2018 Oct 17.

Novel boron-rich, carboranyl-indole carboxamide ligands were prepared and found to effectively target the 18 kDa translocator protein (TSPO), an upregulated mitochondrial membrane-bound protein which has been observed in variety of tumor cell lines and its expression appears to be...

Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence.

Frontiers in human neuroscience

Zhao Q, Li H, Hu B, Li Y, Gillebert CR, Mantini D, Liu Q.
PMID: 29410620
Front Hum Neurosci. 2018 Jan 23;11:646. doi: 10.3389/fnhum.2017.00646. eCollection 2017.

The attention of drug-dependent persons tends to be captured by stimuli associated with drug consumption. This involuntary cognitive process is considered as attentional bias (AB). AB has been hypothesized to have causal effects on drug abuse and drug relapse,...

Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production.

The Journal of organic chemistry

Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DW.
PMID: 30180575
J Org Chem. 2018 Oct 05;83(19):11777-11793. doi: 10.1021/acs.joc.8b01708. Epub 2018 Sep 18.

The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient six-step synthesis, chiral amino acids were...

Do patients consider computer-adaptive measures more appropriate than static questionnaires?.

Journal of patient-reported outcomes

Gamper EM, Martini C, Petersen MA, Virgolini I, Holzner B, Giesinger JM.
PMID: 30694417
J Patient Rep Outcomes. 2019 Jan 29;3(1):7. doi: 10.1186/s41687-019-0096-3.

OBJECTIVE: Computer-adaptive tests (CAT) use individualised sets of questions to assess patient-reported health states, whereas static (conventional) questionnaires present the same questions to all patients. CAT has been shown to increase measurement precision and reduce assessment length. In our...

The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity.

Oncotarget

Amantini C, Farfariello V, Cardinali C, Morelli MB, Marinelli O, Nabissi M, Santoni M, Bonfili L, Cecarini V, Eleuteri AM, Santoni G.
PMID: 29207602
Oncotarget. 2017 Oct 11;8(53):90766-90780. doi: 10.18632/oncotarget.21798. eCollection 2017 Oct 31.

Autophagy and the ubiquitin-proteasome system (UPS) control thymus cell homeostasis under resting and endoplasmic reticulum (ER) stress conditions. Several evidence support a cross-talk between UPS and autophagy; abrogation of UPS responses stimulates autophagy, and vice versa the inhibition of...

Bactericidal Activity of Aqueous Acrylic Paint Dispersion for Wooden Substrates Based on TiO₂ Nanoparticles Activated by Fluorescent Light.

Materials (Basel, Switzerland)

Zuccheri T, Colonna M, Stefanini I, Santini C, Gioia DD.
PMID: 28811435
Materials (Basel). 2013 Aug 02;6(8):3270-3283. doi: 10.3390/ma6083270.

The photocatalytic effect of TiO

Expression of CD38 in myeloma bone niche: A rational basis for the use of anti-CD38 immunotherapy to inhibit osteoclast formation.

Oncotarget

Costa F, Toscani D, Chillemi A, Quarona V, Bolzoni M, Marchica V, Vescovini R, Mancini C, Martella E, Campanini N, Schifano C, Bonomini S, Accardi F, Horenstein AL, Aversa F, Malavasi F, Giuliani N.
PMID: 28915615
Oncotarget. 2017 May 16;8(34):56598-56611. doi: 10.18632/oncotarget.17896. eCollection 2017 Aug 22.

It is known that multiple myeloma (MM) cells express CD38 and that a recently developed human anti-CD38 monoclonal antibody Daratumumab mediates myeloma killing. However, the expression of CD38 and other functionally related ectoenzymes within the MM bone niche and...

Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?.

Clinical & translational immunology

Tan LY, Martini C, Fridlender ZG, Bonder CS, Brown MP, Ebert LM.
PMID: 28435677
Clin Transl Immunology. 2017 Mar 17;6(3):e134. doi: 10.1038/cti.2017.7. eCollection 2017 Mar.

Metastatic melanoma remains a fatal disease to many worldwide, even after the breakthrough introduction of targeted therapies such as BRAF inhibitors and immune checkpoint blockade therapies such as CTLA-4 and PD-1 inhibitors. With advances in our understanding of this...

Bone Marrow CX3CL1/Fractalkine is a New Player of the Pro-Angiogenic Microenvironment in Multiple Myeloma Patients.

Cancers

Marchica V, Toscani D, Corcione A, Bolzoni M, Storti P, Vescovini R, Ferretti E, Dalla Palma B, Vicario E, Accardi F, Mancini C, Martella E, Ribatti D, Vacca A, Pistoia V, Giuliani N.
PMID: 30845779
Cancers (Basel). 2019 Mar 06;11(3). doi: 10.3390/cancers11030321.

C-X3-C motif chemokine ligand 1 (CX3CL1)/fractalkine is a chemokine released after cleavage by two metalloproteases, ADAM metallopeptidase domain 10 (ADAM10) and ADAM metallopeptidase domain 17 (ADAM17), involved in inflammation and angiogenesis in the cancer microenvironment. The role of the...

Melamine-Formaldehyde Microcapsules: Micro- and Nanostructural Characterization with Electron Microscopy.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

Heidari H, Rivero G, Idrissi H, Ramachandran D, Cakir S, Egoavil R, Kurttepeli M, Crabbé AC, Hauffman T, Terryn H, Du Prez F, Schryvers D.
PMID: 27998368
Microsc Microanal. 2016 Dec;22(6):1222-1232. doi: 10.1017/S1431927616012484.

A systematic study has been carried out to compare the surface morphology, shell thickness, mechanical properties, and binding behavior of melamine-formaldehyde microcapsules of 5-30 μm diameter size with various amounts of core content by using scanning and transmission electron...

Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study.

F1000Research

Latronico N, Nattino G, Guarneri B, Fagoni N, Amantini A, Bertolini G.
PMID: 25309729
F1000Res. 2014 Jun 11;3:127. doi: 10.12688/f1000research.3933.1. eCollection 2014.

OBJECTIVES: To evaluate the accuracy of the peroneal nerve test (PENT) in the diagnosis of critical illness polyneuropathy (CIP) and myopathy (CIM) in the intensive care unit (ICU). We hypothesised that abnormal reduction of peroneal compound muscle action potential...

Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival.

Frontiers in oncology

Amantini C, Morelli MB, Nabissi M, Piva F, Marinelli O, Maggi F, Bianchi F, Bittoni A, Berardi R, Giampieri R, Santoni G.
PMID: 31552188
Front Oncol. 2019 Sep 10;9:874. doi: 10.3389/fonc.2019.00874. eCollection 2019.

The interest in liquid biopsy is growing because it could represent a non-invasive prognostic or predictive tool for clinical outcome in patients with pancreatic ductal adenocarcinoma (PDAC), an aggressive and lethal disease. In this pilot study, circulating tumor cells...

Showing 25 to 36 of 394 entries