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Showing 1225 to 1230 of 1230 entries
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Structural parasitology of the malaria parasite Plasmodium falciparum.

Trends in biochemical sciences

Anton L, Cobb DW, Ho CM.
PMID: 34887149
Trends Biochem Sci. 2021 Dec 07; doi: 10.1016/j.tibs.2021.10.006. Epub 2021 Dec 07.

The difficulty of faithfully recapitulating malarial protein complexes in heterologous expression systems has long impeded structural study for much of the Plasmodium falciparum proteome. However, recent advances in single-particle cryo electron microscopy (cryoEM) now enable structure determination at atomic...

Persistent Postthyroidectomy Hypoparathyroidism in the Netherlands.

JAMA otolaryngology-- head & neck surgery

Loncar I, Noltes ME, Dickhoff C, Engelsman AF, Schepers A, Vriens MR, Bouvy ND, Kruijff S, van Ginhoven TM.
PMID: 34617977
JAMA Otolaryngol Head Neck Surg. 2021 Nov 01;147(11):959-965. doi: 10.1001/jamaoto.2021.2475.

IMPORTANCE: Hypoparathyroidism is one of the most common complications after total or completion thyroidectomy. The reported incidence rate of hypoparathyroidism in the literature is highly variable. Data that provide a better understanding of the magnitude of this postoperative complication...

Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors.

Cancers

Senichkin VV, Pervushin NV, Zamaraev AV, Sazonova EV, Zuev AP, Streletskaia AY, Prikazchikova TA, Zatsepin TS, Kovaleva OV, Tchevkina EM, Zhivotovsky B, Kopeina GS.
PMID: 35008345
Cancers (Basel). 2021 Dec 30;14(1). doi: 10.3390/cancers14010181.

BH3 mimetics represent a promising tool in cancer treatment. Recently, the drugs targeting the Mcl-1 protein progressed into clinical trials, and numerous studies are focused on the investigation of their activity in various preclinical models. We investigated two BH3...

Differences sustained between diffuse and limited forms of juvenile systemic sclerosis in expanded international cohort. www.juvenile-scleroderma.com.

Arthritis care & research

Foeldvari I, Klotsche J, Kasapcopur O, Adrovic A, Terreri MT, Sakamoto AP, Stanevicha V, Sztajnbok F, Anton J, Feldman B, Alexeeva E, Katsicas M, Smith V, Avcin T, Marrani E, Kostik M, Lehman T, Sifuentes-Giraldo WA, Vasquez-Canizares N, Appenzeller S, Janarthanan M, Moll M, Nemcova D, Patwardhan A, Santos MJ, Sawhney S, Schonenberg-Meinema D, Battagliotti C, Berntson L, Bica B, Brunner J, Costa-Reis P, Eleftheriou D, Harel L, Horneff G, Kaiser D, Kallinich T, Lazarevic D, Minden K, Nielsen S, Nuruzzaman F, Uziel Y, Helmus N, Torok KS.
PMID: 33787070
Arthritis Care Res (Hoboken). 2021 Mar 30; doi: 10.1002/acr.24609. Epub 2021 Mar 30.

OBJECTIVES: To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (jSSc) patients in the international Juvenile SSc Inception Cohort (jSScC), compare these characteristics between the classically defined diffuse (dcjSSc) and limited cutaneous (lcjSSc) subtypes, and among those with...

Trends and outcomes in primary health care expenditures in low-income and middle-income countries, 2000-2017.

BMJ global health

Schneider MT, Chang AY, Crosby SW, Gloyd S, Harle AC, Lim S, Lozano R, Micah AE, Tsakalos G, Su Y, Murray CJL, Dieleman JL.
PMID: 34385159
BMJ Glob Health. 2021 Aug;6(8). doi: 10.1136/bmjgh-2021-005798.

INTRODUCTION: As the world responds to COVID-19 and aims for the Sustainable Development Goals, the potential for primary healthcare (PHC) is substantial, although the trends and effectiveness of PHC expenditure are unknown. We estimate PHC expenditure for each low-income...

Automated Framework for the Inclusion of a His-Purkinje System in Cardiac Digital Twins of Ventricular Electrophysiology.

Annals of biomedical engineering

Gillette K, Gsell MAF, Bouyssier J, Prassl AJ, Neic A, Vigmond EJ, Plank G.
PMID: 34431016
Ann Biomed Eng. 2021 Aug 24; doi: 10.1007/s10439-021-02825-9. Epub 2021 Aug 24.

Personalized models of cardiac electrophysiology (EP) that match clinical observation with high fidelity, referred to as cardiac digital twins (CDTs), show promise as a tool for tailoring cardiac precision therapies. Building CDTs of cardiac EP relies on the ability...

Showing 1225 to 1230 of 1230 entries