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Showing 661 to 669 of 669 entries
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Collagen Based Multicomponent Interpenetrating Networks as Promising Scaffolds for 3D Culture of Human Neural Stem Cells, Human Astrocytes, and Human Microglia.

ACS applied bio materials

Van Drunen R, Jimenez-Vergara AC, Tsai EH, Tchen R, Cagle T, Agee AB, Roberts J, Steele JM, Munoz-Pinto DJ.
PMID: 35021387
ACS Appl Bio Mater. 2019 Mar 18;2(3):975-980. doi: 10.1021/acsabm.8b00783. Epub 2019 Feb 19.

This work describes for the first time the fabrication and characterization of multicomponent interpenetrating networks composed of collagen I, hyaluronic acid, and poly(ethylene glycol) diacrylate for the 3D culture of human neural stem cells, astrocytes, and microglia. The chemical...

Management of children and adolescents with bronchiectasis: summary of the ERS clinical practice guideline.

Breathe (Sheffield, England)

Chang AB, Grimwood K, Boyd J, Fortescue R, Powell Z, Kantar A.
PMID: 35035559
Breathe (Sheff). 2021 Sep;17(3):210105. doi: 10.1183/20734735.0105-2021.

Bronchiectasis, characterised by chronic wet/productive cough with recurrent respiratory exacerbations and abnormal bronchial dilatation on computed tomography scans, remains an increasingly recognised but often neglected chronic pulmonary disorder in children and adolescents. An early diagnosis combined with optimal management...

Fixation of Acute Chondral Fractures in Adolescent Knees.

Cartilage

Kjennvold S, Randsborg PH, Jakobsen RB, Aroen A.
PMID: 32672055
Cartilage. 2021 Dec;13(1):293S-301S. doi: 10.1177/1947603520941213. Epub 2020 Jul 16.

OBJECTIVES: Chondral fractures are focal cartilage lesions without osseous attachment, most commonly seen in adolescent knees. They have limited capacity for intrinsic healing and traditional treatment has been removal of loose fragments. However, case reports of successful healing after...

A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway.

Molecular cancer therapeutics

Wurm M, Schaaf O, Reutner K, Ganesan R, Mostböck S, Pelster C, Böttcher J, de Andrade Pereira B, Taubert C, Alt I, Serna G, Auguste A, Stadermann KB, Delic D, Han F, Capdevila J, Nuciforo PG, Kroe-Barrett R, Adam PJ, Vogt AB, Hofmann I.
PMID: 34482286
Mol Cancer Ther. 2021 Nov;20(11):2250-2261. doi: 10.1158/1535-7163.MCT-21-0107. Epub 2021 Sep 04.

Despite some impressive clinical results with immune checkpoint inhibitors, the majority of patients with cancer do not respond to these agents, in part due to immunosuppressive mechanisms in the tumor microenvironment. High levels of adenosine in tumors can suppress...

Multilocus Sequence Typing of Aggregatibacter actinomycetemcomitans Competently Depicts the Population Structure of the Species.

Microbiology spectrum

Nedergaard S, Jensen AB, Haubek D, Nørskov-Lauritsen N.
PMID: 34908433
Microbiol Spectr. 2021 Dec 15;e0108521. doi: 10.1128/Spectrum.01085-21. Epub 2021 Dec 15.

We developed a multilocus sequence typing scheme (MLST) for Aggregatibacter actinomycetemcomitans based on seven housekeeping genes,

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.

Cancer cell

Seong BKA, Dharia NV, Lin S, Donovan KA, Chong S, Robichaud A, Conway A, Hamze A, Ross L, Alexe G, Adane B, Nabet B, Ferguson FM, Stolte B, Wang EJ, Sun J, Darzacq X, Piccioni F, Gray NS, Fischer ES, Stegmaier K.
PMID: 34329586
Cancer Cell. 2021 Sep 13;39(9):1262-1278.e7. doi: 10.1016/j.ccell.2021.07.003. Epub 2021 Jul 29.

Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to target these challenging oncoproteins. The mechanisms that regulate fusion-TF stability, however, are generally unknown. Using...

Exocrine Pancreatic Dysfunction in Diabetes: An Observational Study.

Indian journal of endocrinology and metabolism

Ghosh I, Basu M, Anne B, Mukhopadhyay P, Ghosh S.
PMID: 34386397
Indian J Endocrinol Metab. 2021 Jan-Feb;25(1):67-68. doi: 10.4103/ijem.IJEM_822_20. Epub 2021 Jul 21.

No abstract available.

Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis.

Frontiers in microbiology

Broderick DTJ, Waite DW, Marsh RL, Camargo CA, Cardenas P, Chang AB, Cookson WOC, Cuthbertson L, Dai W, Everard ML, Gervaix A, Harris JK, Hasegawa K, Hoffman LR, Hong SJ, Josset L, Kelly MS, Kim BS, Kong Y, Li SC, Mansbach JM, Mejias A, O'Toole GA, Paalanen L, Pérez-Losada M, Pettigrew MM, Pichon M, Ramilo O, Ruokolainen L, Sakwinska O, Seed PC, van der Gast CJ, Wagner BD, Yi H, Zemanick ET, Zheng Y, Pillarisetti N, Taylor MW.
PMID: 35002989
Front Microbiol. 2021 Dec 23;12:711134. doi: 10.3389/fmicb.2021.711134. eCollection 2021.

No abstract available.

Emergence of Salmonid Alphavirus Genotype 2 in Norway-Molecular Characterization of Viral Strains Circulating in Norway and Scotland.

Viruses

Hjortaas MJ, Fringuelli E, Monjane AL, Mikalsen AB, Jonassen CM, Savage P, Sindre H.
PMID: 34452421
Viruses. 2021 Aug 06;13(8). doi: 10.3390/v13081556.

Pancreas disease (PD) and sleeping disease (SD), caused by an alphavirus, are endemic in European salmonid aquaculture, causing significant mortality, reduced growth and poor flesh quality. In 2010, a new variant of salmonid alphavirus emerged in Norway, marine salmonid...

Showing 661 to 669 of 669 entries