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Showing 169 to 177 of 177 entries
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Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice.

Hepatology communications

Holland CH, Ramirez Flores RO, Myllys M, Hassan R, Edlund K, Hofmann U, Marchan R, Cadenas C, Reinders J, Hoehme S, Seddek AL, Dooley S, Keitel V, Godoy P, Begher-Tibbe B, Trautwein C, Rupp C, Mueller S, Longerich T, Hengstler JG, Saez-Rodriguez J, Ghallab A.
PMID: 34558834
Hepatol Commun. 2022 Jan;6(1):161-177. doi: 10.1002/hep4.1797. Epub 2021 Aug 28.

Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used mouse models to human CLDs based on transcriptome data. Gene-expression data from 372 patients were compared...

Sputum Proteomics in non-Tuberculous Mycobacterial Lung Disease.

Chest

Hull RC, Huang JT, Barton AK, Keir HR, Ellis H, Cookson W, Moffatt M, Loebinger M, Chalmers JD.
PMID: 34838525
Chest. 2021 Nov 24; doi: 10.1016/j.chest.2021.11.014. Epub 2021 Nov 24.

BACKGROUND: Non-tuberculous mycobacterial (NTM) infections are difficult to diagnose and treat. Biomarkers to identify patients with active infection or at risk of disease progression would have clinical utility. Sputum is the most frequently used matrix for diagnosis of NTM...

Learning Disabilities Elevate Children's Risk for Behavioral-Emotional Problems: Differences Between LD Types, Genders, and Contexts.

Journal of learning disabilities

Aro T, Eklund K, Eloranta AK, Ahonen T, Rescorla L.
PMID: 34779295
J Learn Disabil. 2021 Nov 13;222194211056297. doi: 10.1177/00222194211056297. Epub 2021 Nov 13.

Our purpose was to study the frequency of behavioral-emotional problems among children identified with a learning disability (LD). The data comprised 579 Finnish children (8-15 years) with reading disability (RD-only), math disability (MD-only), or both (RDMD) assessed at a...

Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon.

Journal of visualized experiments : JoVE

Silva MS, Stewart T, Amlund H, Sloth JJ, Araujo P, Lock EJ, Hogstrand C, Ørnsrud R, Waagbø R, Prabhu AJ.
PMID: 34779429
J Vis Exp. 2021 Oct 29;(176). doi: 10.3791/59862.

Assessing the availability of dietary micro-minerals is a major challenge in mineral nutrition of fish species. The present article aims to describe a systematic approach combining different methodologies to assess the availability of zinc (Zn) in Atlantic salmon (Salmo...

Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice.

Hepatology communications

Holland CH, Ramirez Flores RO, Myllys M, Hassan R, Edlund K, Hofmann U, Marchan R, Cadenas C, Reinders J, Hoehme S, Seddek AL, Dooley S, Keitel V, Godoy P, Begher-Tibbe B, Trautwein C, Rupp C, Mueller S, Longerich T, Hengstler JG, Saez-Rodriguez J, Ghallab A.
PMID: 34558834
Hepatol Commun. 2021 Aug 28; doi: 10.1002/hep4.1797. Epub 2021 Aug 28.

Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used mouse models to human CLDs based on transcriptome data. Gene-expression data from 372 patients were compared...

Interferon-γ and Hypoxia Priming Have Limited Effect on the miRNA Landscape of Human Mesenchymal Stromal Cells-Derived Extracellular Vesicles.

Frontiers in cell and developmental biology

Peltzer J, Lund K, Goriot ME, Grosbot M, Lataillade JJ, Mauduit P, Banzet S.
PMID: 33384991
Front Cell Dev Biol. 2020 Dec 15;8:581436. doi: 10.3389/fcell.2020.581436. eCollection 2020.

Mesenchymal stromal cell (MSC)-based cell therapy has received great interest in regenerative medicine. Priming the cells during the culture phase can improve their efficacy and/or survival after injection. The literature suggests that MSC extracellular vesicles (EV) can recapitulate a...

Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice.

Frontiers in endocrinology

Ovlund T, Pacini G, Ahrén B.
PMID: 34168617
Front Endocrinol (Lausanne). 2021 Jun 08;12:680153. doi: 10.3389/fendo.2021.680153. eCollection 2021.

A large contribution to glucose elimination from the circulation is achieved by insulin-independent processes. We have previously shown that the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) increase this process and, therefore, seem to contribute...

ZTTK syndrome: Clinical and molecular findings of 15 cases and a review of the literature.

American journal of medical genetics. Part A

Kushary ST, Revah-Politi A, Barua S, Ganapathi M, Accogli A, Aggarwal V, Brunetti-Pierri N, Cappuccio G, Capra V, Fagerberg CR, Gazdagh G, Guzman E, Hadonou M, Harrison V, Havelund K, Iancu D, Kraus A, Lippa NC, Mansukhani M, McBrian D, McEntagart M, Pacio-Míguez M, Palomares-Bralo M, Pottinger C, Ruivenkamp CAL, Sacco O, Santen GWE, Santos-Simarro F, Scala M, Short J, Sørensen KP, Woods CG, Anyane Yeboa K.
PMID: 34331327
Am J Med Genet A. 2021 Dec;185(12):3740-3753. doi: 10.1002/ajmg.a.62445. Epub 2021 Jul 31.

Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is caused by de novo loss-of-function variants in the SON gene (MIM #617140). This multisystemic disorder is characterized by intellectual disability, seizures, abnormal brain imaging, variable dysmorphic features, and various congenital anomalies. The wide application and...

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.

Chemico-biological interactions

Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Vartak N, Edlund K, Marchan R, Ghallab A, Cadenas C, Günther G, Leist M, Zhang M, Gardner I, Reinders J, Russel FG, Foster AJ, Williams DP, Damle-Vartak A, Grandits M, Ecker G, Kittana N, Rahnenführer J, Hengstler JG.
PMID: 34717914
Chem Biol Interact. 2021 Oct 27;351:109728. doi: 10.1016/j.cbi.2021.109728. Epub 2021 Oct 27.

An in vitro/in silico method that determines the risk of human drug induced liver injury in relation to oral doses and blood concentrations of drugs was recently introduced. This method utilizes information on the maximal blood concentration (C

Showing 169 to 177 of 177 entries