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Showing 241 to 248 of 248 entries
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Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia.

Frontiers in physiology

Hannemann J, Cordts K, Seniuk A, Choe CU, Schmidt-Hutten L, Duque Escobar J, Weinberger F, Böger R, Schwedhelm E.
PMID: 34483959
Front Physiol. 2021 Aug 18;12:703069. doi: 10.3389/fphys.2021.703069. eCollection 2021.

No abstract available.

Metabolism of asymmetric dimethylarginine in hypoxia: from bench to bedside.

Pulmonary circulation

Hannemann J, Zummack J, Hillig J, Böger R.
PMID: 32313644
Pulm Circ. 2020 Apr 14;10(2):2045894020918846. doi: 10.1177/2045894020918846. eCollection 2020.

Acute hypoxia and chronic hypoxia induce pulmonary vasoconstriction. While hypoxic pulmonary vasoconstriction is a physiological response if parts of the lung are affected, global exposure to hypoxic conditions may lead to clinical conditions like high-altitude pulmonary hypertension. Nitric oxide...

L-homoarginine is associated with decreased cardiovascular- and all-cause mortality.

European journal of clinical investigation

Mokhaneli MC, Botha-Le Roux S, Fourie CMT, Böger R, Schwedhelm E, Mels CMC.
PMID: 33320332
Eur J Clin Invest. 2021 May;51(5):e13472. doi: 10.1111/eci.13472. Epub 2020 Dec 24.

BACKGROUND: Increasing evidence suggests that L-homoarginine, an endogenous analogue of the amino acid L-arginine, may have beneficial effects on vascular homeostasis. We examined whether L-homoarginine is associated with 10-year risk of all-cause and cardiovascular mortality in a black South...

Influence of counterion valency on the conformational behavior of cylindrical polyelectrolyte brushes.

The journal of physical chemistry. B

Yan LT, Xu Y, Ballauff M, Müller AH, Böker A.
PMID: 19354302
J Phys Chem B. 2009 Apr 16;113(15):5104-10. doi: 10.1021/jp810648z.

Using a dissipative particle dynamics approach, we study the conformations and interactions of a cylindrical polyelectrolyte brush (CPB) with added salt. The effects of counterion valency on the conformational behaviors of the CPB are analyzed in detail by considering...

Acceptance and completion of rifapentine-based TB preventive therapy (3HP) among people living with HIV (PLHIV) in Kampala, Uganda-patient and health worker perspectives.

Implementation science communications

Semitala FC, Musinguzi A, Ssemata J, Welishe F, Nabunje J, Kadota JL, Berger CA, Katamba A, Kiwanuka N, Kamya MR, Dowdy D, Cattamanchi A, Katahoire AR.
PMID: 34193311
Implement Sci Commun. 2021 Jun 30;2(1):71. doi: 10.1186/s43058-021-00173-2.

BACKGROUND: A 12-dose, once-weekly regimen of isoniazid and rifapentine (3HP) is effective in preventing tuberculosis (TB) among people living with HIV (PLHIV). We sought to identify potential barriers to and facilitators of acceptance and completion of 3HP treatment from...

Completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV: Interim analysis of a hybrid type 3 effectiveness-implementation randomized trial.

PLoS medicine

Semitala FC, Kadota JL, Musinguzi A, Nabunje J, Welishe F, Nakitende A, Akello L, Bishop O, Patel D, Sammann A, Nahid P, Belknap R, Kamya MR, Handley MA, Phillips PPJ, Katahoire A, Berger CA, Kiwanuka N, Katamba A, Dowdy DW, Cattamanchi A.
PMID: 34914696
PLoS Med. 2021 Dec 16;18(12):e1003875. doi: 10.1371/journal.pmed.1003875. eCollection 2021 Dec.

BACKGROUND: Scaling up shorter regimens for tuberculosis (TB) prevention such as once weekly isoniazid-rifapentine (3HP) taken for 3 months is a key priority for achieving targets set forth in the World Health Organization's (WHO) END TB Strategy. However, there...

Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer.

NPJ breast cancer

Liu YL, Bager CL, Willumsen N, Ramchandani D, Kornhauser N, Ling L, Cobham M, Andreopoulou E, Cigler T, Moore A, LaPolla D, Fitzpatrick V, Ward M, Warren JD, Fischbach C, Mittal V, Vahdat LT.
PMID: 34426581
NPJ Breast Cancer. 2021 Aug 23;7(1):108. doi: 10.1038/s41523-021-00313-w.

Tetrathiomolybdate (TM) is a novel, copper-depleting compound associated with promising survival in a phase II study of patients with high-risk and triple-negative breast cancer. We sought to elucidate the mechanism of TM by exploring its effects on collagen processing...

The development of place value concepts: Approximation before principles.

Child development

Mix KS, Bower CA, Hancock GR, Yuan L, Smith LB.
PMID: 35023576
Child Dev. 2022 Jan 13; doi: 10.1111/cdev.13724. Epub 2022 Jan 13.

Place value concepts were measured longitudinally from kindergarten (2017) to first grade (2018) in a diverse sample (n = 279; M

Showing 241 to 248 of 248 entries