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Showing 229 to 231 of 231 entries
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Natural Course of the Diffusing Capacity of the Lungs for Carbon Monoxide in COPD: Importance of Sex.

Chest

Casanova C, Gonzalez-Dávila E, Martínez-Gonzalez C, Cosio BG, Fuster A, Feu N, Solanes I, Cabrera C, Marin JM, Balcells E, Peces-Barba G, de Torres JP, Marín-Oto M, Calle M, Golpe R, Ojeda E, Divo M, Pinto-Plata V, Amado C, López-Campos JL, Celli BR.
PMID: 33878339
Chest. 2021 Aug;160(2):481-490. doi: 10.1016/j.chest.2021.03.069. Epub 2021 Apr 18.

BACKGROUND: The value of the single-breath diffusing capacity of the lungs for carbon monoxide (Dlco) relates to outcomes for patients with COPD. However, little is known about the natural course of Dlco over time, intersubject variability, and factors that...

Standardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Bartolome F, Orive G, Carro E.
PMID: 33969170
Alzheimers Dement (Amst). 2021 May 02;13(1):e12173. doi: 10.1002/dad2.12173. eCollection 2021.

The search for new, robust, and reproducible biomarkers for Alzheimer's disease (AD) diagnosis is a challenge. We recently reported that salivary lactoferrin (Lf) could be presented as new biomarker candidate for AD, being both non-invasive and cost-effective, as well...

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial.

The Lancet. Respiratory medicine

Rabe KF, Celli BR, Wechsler ME, Abdulai RM, Luo X, Boomsma MM, Staudinger H, Horowitz JE, Baras A, Ferreira MA, Ruddy MK, Nivens MC, Amin N, Weinreich DM, Yancopoulos GD, Goulaouic H.
PMID: 34302758
Lancet Respir Med. 2021 Nov;9(11):1288-1298. doi: 10.1016/S2213-2600(21)00167-3. Epub 2021 Jul 21.

BACKGROUND: Genetic data implicate IL-33 in asthma susceptibility. Itepekimab, a monoclonal antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic obstructive pulmonary disease (COPD). In this study we first aimed to test the hypothesis that genetic...

Showing 229 to 231 of 231 entries