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Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors".

Drug safety

Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, Bernard G, Ekstrom L, Lancaster WJ, Denny JC.
PMID: 30066313
Drug Saf. 2018 Nov;41(11):1101. doi: 10.1007/s40264-018-0701-z.

No abstract available.

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Jerome RN, Pulley JM, Roden DM, et al. Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors". Drug Saf. 2018;41(11):1101doi: 10.1007/s40264-018-0701-z.
Jerome, R. N., Pulley, J. M., Roden, D. M., Shirey-Rice, J. K., Bastarache, L. A., Bernard, G., Ekstrom, L., Lancaster, W. J., & Denny, J. C. (2018). Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors". Drug safety, 41(11), 1101. https://doi.org/10.1007/s40264-018-0701-z
Jerome, Rebecca N, et al. "Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors"." Drug safety vol. 41,11 (2018): 1101. doi: https://doi.org/10.1007/s40264-018-0701-z
Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, Bernard G, Ekstrom L, Lancaster WJ, Denny JC. Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors". Drug Saf. 2018 Nov;41(11):1101. doi: 10.1007/s40264-018-0701-z. PMID: 30066313.
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Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies.

Journal of research in personality

Graham EK, Rutsohn JP, Turiano NA, Bendayan R, Batterham PJ, Gerstorf D, Katz MJ, Reynolds CA, Sharp ES, Yoneda TB, Bastarache ED, Elleman LG, Zelinski EM, Johansson B, Kuh D, Barnes LL, Bennett DA, Deeg DJH, Lipton RB, Pedersen NL, Piccinin AM, Spiro A, Muniz-Terrera G, Willis SL, Schaie KW, Roan C, Herd P, Hofer SM, Mroczek DK.
PMID: 29230075
J Res Pers. 2017 Oct;70:174-186. doi: 10.1016/j.jrp.2017.07.005. Epub 2017 Jul 22.

This study examined the Big Five personality traits as predictors of mortality risk, and smoking as a mediator of that association. Replication was built into the fabric of our design: we used a Coordinated Analysis with 15 international datasets,...

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Graham EK, Rutsohn JP, Turiano NA, et al. Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. J Res Pers. 2017;70:174-186doi: 10.1016/j.jrp.2017.07.005.
Graham, E. K., Rutsohn, J. P., Turiano, N. A., Bendayan, R., Batterham, P. J., Gerstorf, D., Katz, M. J., Reynolds, C. A., Sharp, E. S., Yoneda, T. B., Bastarache, E. D., Elleman, L. G., Zelinski, E. M., Johansson, B., Kuh, D., Barnes, L. L., Bennett, D. A., Deeg, D. J. H., Lipton, R. B., Pedersen, N. L., Piccinin, A. M., Spiro, A., Muniz-Terrera, G., Willis, S. L., Schaie, K. W., Roan, C., Herd, P., Hofer, S. M., & Mroczek, D. K. (2017). Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. Journal of research in personality, 70174-186. https://doi.org/10.1016/j.jrp.2017.07.005
Graham, Eileen K, et al. "Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies." Journal of research in personality vol. 70 (2017): 174-186. doi: https://doi.org/10.1016/j.jrp.2017.07.005
Graham EK, Rutsohn JP, Turiano NA, Bendayan R, Batterham PJ, Gerstorf D, Katz MJ, Reynolds CA, Sharp ES, Yoneda TB, Bastarache ED, Elleman LG, Zelinski EM, Johansson B, Kuh D, Barnes LL, Bennett DA, Deeg DJH, Lipton RB, Pedersen NL, Piccinin AM, Spiro A, Muniz-Terrera G, Willis SL, Schaie KW, Roan C, Herd P, Hofer SM, Mroczek DK. Personality Predicts Mortality Risk: An Integrative Data Analysis of 15 International Longitudinal Studies. J Res Pers. 2017 Oct;70:174-186. doi: 10.1016/j.jrp.2017.07.005. Epub 2017 Jul 22. PMID: 29230075; PMCID: PMC5722274.
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Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury.

Clinical and translational medicine

Ma L, Shaver CM, Grove BS, Mitchell DB, Wickersham NE, Carnahan RH, Cooper TL, Brake BE, Ware LB, Bastarache JA.
PMID: 26154059
Clin Transl Med. 2015 Dec;4(1):63. doi: 10.1186/s40169-015-0063-4. Epub 2015 Jun 21.

BACKGROUND: Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and inflammation are unknown.METHODS: To...

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Ma L, Shaver CM, Grove BS, et al. Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury. Clin Transl Med. 2015;4(1):63doi: 10.1186/s40169-015-0063-4.
Ma, L., Shaver, C. M., Grove, B. S., Mitchell, D. B., Wickersham, N. E., Carnahan, R. H., Cooper, T. L., Brake, B. E., Ware, L. B., & Bastarache, J. A. (2015). Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury. Clinical and translational medicine, 4(1), 63. https://doi.org/10.1186/s40169-015-0063-4
Ma, Li, et al. "Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury." Clinical and translational medicine vol. 4,1 (2015): 63. doi: https://doi.org/10.1186/s40169-015-0063-4
Ma L, Shaver CM, Grove BS, Mitchell DB, Wickersham NE, Carnahan RH, Cooper TL, Brake BE, Ware LB, Bastarache JA. Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury. Clin Transl Med. 2015 Dec;4(1):63. doi: 10.1186/s40169-015-0063-4. Epub 2015 Jun 21. PMID: 26154059; PMCID: PMC4495096.
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Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.

Frontiers in genetics

Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, Pathak J, Bielinski SJ, Carrell DS, Crosslin DR, Ledbetter DH, Carey DJ, Tromp G, Williams MS, Larson EB, Jarvik GP, Peissig PL, Brilliant MH, McCarty CA, Chute CG, Kullo IJ, Bottinger E, Chisholm R, Smith ME, Roden DM, Denny JC.
PMID: 25177340
Front Genet. 2014 Aug 05;5:250. doi: 10.3389/fgene.2014.00250. eCollection 2014.

Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in...

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Cronin RM, Field JR, Bradford Y, et al. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Front Genet. 2014;5:250doi: 10.3389/fgene.2014.00250.
Cronin, R. M., Field, J. R., Bradford, Y., Shaffer, C. M., Carroll, R. J., Mosley, J. D., Bastarache, L., Edwards, T. L., Hebbring, S. J., Lin, S., Hindorff, L. A., Crane, P. K., Pendergrass, S. A., Ritchie, M. D., Crawford, D. C., Pathak, J., Bielinski, S. J., Carrell, D. S., Crosslin, D. R., Ledbetter, D. H., Carey, D. J., Tromp, G., Williams, M. S., Larson, E. B., Jarvik, G. P., Peissig, P. L., Brilliant, M. H., McCarty, C. A., Chute, C. G., Kullo, I. J., Bottinger, E., Chisholm, R., Smith, M. E., Roden, D. M., & Denny, J. C. (2014). Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Frontiers in genetics, 5250. https://doi.org/10.3389/fgene.2014.00250
Cronin, Robert M, et al. "Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index." Frontiers in genetics vol. 5 (2014): 250. doi: https://doi.org/10.3389/fgene.2014.00250
Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, Pathak J, Bielinski SJ, Carrell DS, Crosslin DR, Ledbetter DH, Carey DJ, Tromp G, Williams MS, Larson EB, Jarvik GP, Peissig PL, Brilliant MH, McCarty CA, Chute CG, Kullo IJ, Bottinger E, Chisholm R, Smith ME, Roden DM, Denny JC. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Front Genet. 2014 Aug 05;5:250. doi: 10.3389/fgene.2014.00250. eCollection 2014. PMID: 25177340; PMCID: PMC4134007.
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Advancing precision medicine for acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS.
PMID: 34310901
Lancet Respir Med. 2021 Jul 23; doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23.

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have...

Cite
Beitler JR, Thompson BT, Baron RM, et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021;doi: 10.1016/S2213-2600(21)00157-0.
Beitler, J. R., Thompson, B. T., Baron, R. M., Bastarache, J. A., Denlinger, L. C., Esserman, L., Gong, M. N., LaVange, L. M., Lewis, R. J., Marshall, J. C., Martin, T. R., McAuley, D. F., Meyer, N. J., Moss, M., Reineck, L. A., Rubin, E., Schmidt, E. P., Standiford, T. J., Ware, L. B., Wong, H. R., Aggarwal, N. R., & Calfee, C. S. (2021). Advancing precision medicine for acute respiratory distress syndrome. The Lancet. Respiratory medicine, . https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler, Jeremy R, et al. "Advancing precision medicine for acute respiratory distress syndrome." The Lancet. Respiratory medicine vol. (2021). doi: https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021 Jul 23; doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23. PMID: 34310901; PMCID: PMC8302189.
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Multi-omic analysis elucidates the genetic basis of hydrocephalus.

Cell reports

Hale AT, Bastarache L, Morales DM, Wellons JC, Limbrick DD, Gamazon ER.
PMID: 33951428
Cell Rep. 2021 May 04;35(5):109085. doi: 10.1016/j.celrep.2021.109085.

We conducted PrediXcan analysis of hydrocephalus risk in ten neurological tissues and whole blood. Decreased expression of MAEL in the brain was significantly associated (Bonferroni-adjusted p < 0.05) with hydrocephalus. PrediXcan analysis of brain imaging and genomics data in...

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Hale AT, Bastarache L, Morales DM, et al. Multi-omic analysis elucidates the genetic basis of hydrocephalus. Cell Rep. 2021;35(5):109085doi: 10.1016/j.celrep.2021.109085.
Hale, A. T., Bastarache, L., Morales, D. M., Wellons, J. C., Limbrick, D. D., & Gamazon, E. R. (2021). Multi-omic analysis elucidates the genetic basis of hydrocephalus. Cell reports, 35(5), 109085. https://doi.org/10.1016/j.celrep.2021.109085
Hale, Andrew T, et al. "Multi-omic analysis elucidates the genetic basis of hydrocephalus." Cell reports vol. 35,5 (2021): 109085. doi: https://doi.org/10.1016/j.celrep.2021.109085
Hale AT, Bastarache L, Morales DM, Wellons JC, Limbrick DD, Gamazon ER. Multi-omic analysis elucidates the genetic basis of hydrocephalus. Cell Rep. 2021 May 04;35(5):109085. doi: 10.1016/j.celrep.2021.109085. PMID: 33951428; PMCID: PMC8124085.
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Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients.

JAMA internal medicine

Van Driest SL, Abul-Husn NS, Glessner JT, Bastarache L, Nirenberg S, Schildcrout JS, Eswarappa MS, Belbin GM, Shaffer CM, Mentch F, Connolly J, Shi M, Stein CM, Roden DM, Hakonarson H, Cox NJ, Borinstein SC, Mosley JD.
PMID: 34180972
JAMA Intern Med. 2021 Aug 01;181(8):1100-1105. doi: 10.1001/jamainternmed.2021.3108.

IMPORTANCE: Up to two-thirds of African American individuals carry the benign rs2814778-CC genotype that lowers total white blood cell (WBC) count.OBJECTIVE: To examine whether the rs2814778-CC genotype is associated with an increased likelihood of receiving a bone marrow biopsy...

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Van Driest SL, Abul-Husn NS, Glessner JT, et al. Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients. JAMA Intern Med. 2021;181(8):1100-1105doi: 10.1001/jamainternmed.2021.3108.
Van Driest, S. L., Abul-Husn, N. S., Glessner, J. T., Bastarache, L., Nirenberg, S., Schildcrout, J. S., Eswarappa, M. S., Belbin, G. M., Shaffer, C. M., Mentch, F., Connolly, J., Shi, M., Stein, C. M., Roden, D. M., Hakonarson, H., Cox, N. J., Borinstein, S. C., & Mosley, J. D. (2021). Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients. JAMA internal medicine, 181(8), 1100-1105. https://doi.org/10.1001/jamainternmed.2021.3108
Van Driest, Sara L, et al. "Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients." JAMA internal medicine vol. 181,8 (2021): 1100-1105. doi: https://doi.org/10.1001/jamainternmed.2021.3108
Van Driest SL, Abul-Husn NS, Glessner JT, Bastarache L, Nirenberg S, Schildcrout JS, Eswarappa MS, Belbin GM, Shaffer CM, Mentch F, Connolly J, Shi M, Stein CM, Roden DM, Hakonarson H, Cox NJ, Borinstein SC, Mosley JD. Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients. JAMA Intern Med. 2021 Aug 01;181(8):1100-1105. doi: 10.1001/jamainternmed.2021.3108. PMID: 34180972; PMCID: PMC8239990.
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Advancing precision medicine for acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS.
PMID: 34310901
Lancet Respir Med. 2022 Jan;10(1):107-120. doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23.

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have...

Cite
Beitler JR, Thompson BT, Baron RM, et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021;10(1):107-120doi: 10.1016/S2213-2600(21)00157-0.
Beitler, J. R., Thompson, B. T., Baron, R. M., Bastarache, J. A., Denlinger, L. C., Esserman, L., Gong, M. N., LaVange, L. M., Lewis, R. J., Marshall, J. C., Martin, T. R., McAuley, D. F., Meyer, N. J., Moss, M., Reineck, L. A., Rubin, E., Schmidt, E. P., Standiford, T. J., Ware, L. B., Wong, H. R., Aggarwal, N. R., & Calfee, C. S. (2022). Advancing precision medicine for acute respiratory distress syndrome. The Lancet. Respiratory medicine, 10(1), 107-120. https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler, Jeremy R, et al. "Advancing precision medicine for acute respiratory distress syndrome." The Lancet. Respiratory medicine vol. 10,1 (2022): 107-120. doi: https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2022 Jan;10(1):107-120. doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23. PMID: 34310901; PMCID: PMC8302189.
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Trajectories of Big Five Personality Traits: A Coordinated Analysis of 16 Longitudinal Samples.

European journal of personality

Graham EK, Weston SJ, Gerstorf D, Yoneda TB, Booth T, Beam CR, Petkus AJ, Drewelies J, Hall AN, Bastarache ED, Estabrook R, Katz MJ, Turiano NA, Lindenberger U, Smith J, Wagner GG, Pedersen NL, Allemand M, Spiro A, Deeg DJH, Johansson B, Piccinin AM, Lipton RB, Schaie KW, Willis S, Reynolds CA, Deary IJ, Hofer SM, Mroczek DK.
PMID: 33564207
Eur J Pers. 2020 May;34(3):301-321. doi: 10.1002/per.2259. Epub 2020 May 01.

This study assessed change in self-reported Big Five personality traits. We conducted a coordinated integrative data analysis using data from 16 longitudinal samples, comprising a total sample of over 60 000 participants. We coordinated models across multiple datasets and...

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Graham EK, Weston SJ, Gerstorf D, et al. Trajectories of Big Five Personality Traits: A Coordinated Analysis of 16 Longitudinal Samples. Eur J Pers. 2020;34(3):301-321doi: 10.1002/per.2259.
Graham, E. K., Weston, S. J., Gerstorf, D., Yoneda, T. B., Booth, T., Beam, C. R., Petkus, A. J., Drewelies, J., Hall, A. N., Bastarache, E. D., Estabrook, R., Katz, M. J., Turiano, N. A., Lindenberger, U., Smith, J., Wagner, G. G., Pedersen, N. L., Allemand, M., Spiro, A., Deeg, D. J. H., Johansson, B., Piccinin, A. M., Lipton, R. B., Schaie, K. W., Willis, S., Reynolds, C. A., Deary, I. J., Hofer, S. M., & Mroczek, D. K. (2020). Trajectories of Big Five Personality Traits: A Coordinated Analysis of 16 Longitudinal Samples. European journal of personality, 34(3), 301-321. https://doi.org/10.1002/per.2259
Graham, Eileen K, et al. "Trajectories of Big Five Personality Traits: A Coordinated Analysis of 16 Longitudinal Samples." European journal of personality vol. 34,3 (2020): 301-321. doi: https://doi.org/10.1002/per.2259
Graham EK, Weston SJ, Gerstorf D, Yoneda TB, Booth T, Beam CR, Petkus AJ, Drewelies J, Hall AN, Bastarache ED, Estabrook R, Katz MJ, Turiano NA, Lindenberger U, Smith J, Wagner GG, Pedersen NL, Allemand M, Spiro A, Deeg DJH, Johansson B, Piccinin AM, Lipton RB, Schaie KW, Willis S, Reynolds CA, Deary IJ, Hofer SM, Mroczek DK. Trajectories of Big Five Personality Traits: A Coordinated Analysis of 16 Longitudinal Samples. Eur J Pers. 2020 May;34(3):301-321. doi: 10.1002/per.2259. Epub 2020 May 01. PMID: 33564207; PMCID: PMC7869960.
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Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions.

NPJ genomic medicine

Li H, Achour I, Bastarache L, Berghout J, Gardeux V, Li J, Lee Y, Pesce L, Yang X, Ramos KS, Foster I, Denny JC, Moore JH, Lussier YA.
PMID: 27482468
NPJ Genom Med. 2016;1. doi: 10.1038/npjgenmed.2016.6. Epub 2016 Apr 27.

Functionally altered biological mechanisms arising from disease-associated polymorphisms, remain difficult to characterize when those variants are intergenic, or, fall between genes. We sought to identify shared downstream mechanisms by which inter- and intragenic single nucleotide polymorphisms (SNPs) contribute to...

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Li H, Achour I, Bastarache L, et al. Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. NPJ Genom Med. 2016;1doi: 10.1038/npjgenmed.2016.6.
Li, H., Achour, I., Bastarache, L., Berghout, J., Gardeux, V., Li, J., Lee, Y., Pesce, L., Yang, X., Ramos, K. S., Foster, I., Denny, J. C., Moore, J. H., & Lussier, Y. A. (2016). Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. NPJ genomic medicine, 1. https://doi.org/10.1038/npjgenmed.2016.6
Li, Haiquan, et al. "Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions." NPJ genomic medicine vol. 1 (2016). doi: https://doi.org/10.1038/npjgenmed.2016.6
Li H, Achour I, Bastarache L, Berghout J, Gardeux V, Li J, Lee Y, Pesce L, Yang X, Ramos KS, Foster I, Denny JC, Moore JH, Lussier YA. Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. NPJ Genom Med. 2016;1. doi: 10.1038/npjgenmed.2016.6. Epub 2016 Apr 27. PMID: 27482468; PMCID: PMC4966659.
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Advancing precision medicine for acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS.
PMID: 34310901
Lancet Respir Med. 2022 Jan;10(1):107-120. doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23.

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have...

Cite
Beitler JR, Thompson BT, Baron RM, et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021;10(1):107-120doi: 10.1016/S2213-2600(21)00157-0.
Beitler, J. R., Thompson, B. T., Baron, R. M., Bastarache, J. A., Denlinger, L. C., Esserman, L., Gong, M. N., LaVange, L. M., Lewis, R. J., Marshall, J. C., Martin, T. R., McAuley, D. F., Meyer, N. J., Moss, M., Reineck, L. A., Rubin, E., Schmidt, E. P., Standiford, T. J., Ware, L. B., Wong, H. R., Aggarwal, N. R., & Calfee, C. S. (2022). Advancing precision medicine for acute respiratory distress syndrome. The Lancet. Respiratory medicine, 10(1), 107-120. https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler, Jeremy R, et al. "Advancing precision medicine for acute respiratory distress syndrome." The Lancet. Respiratory medicine vol. 10,1 (2022): 107-120. doi: https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2022 Jan;10(1):107-120. doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23. PMID: 34310901; PMCID: PMC8302189.
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Phenome-Wide Association Studies.

JAMA

Bastarache L, Denny JC, Roden DM.
PMID: 34982132
JAMA. 2022 Jan 04;327(1):75-76. doi: 10.1001/jama.2021.20356.

No abstract available.

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Bastarache L, Denny JC, Roden DM. Phenome-Wide Association Studies. JAMA. 2022;327(1):75-76doi: 10.1001/jama.2021.20356.
Bastarache, L., Denny, J. C., & Roden, D. M. (2022). Phenome-Wide Association Studies. JAMA, 327(1), 75-76. https://doi.org/10.1001/jama.2021.20356
Bastarache, Lisa, et al. "Phenome-Wide Association Studies." JAMA vol. 327,1 (2022): 75-76. doi: https://doi.org/10.1001/jama.2021.20356
Bastarache L, Denny JC, Roden DM. Phenome-Wide Association Studies. JAMA. 2022 Jan 04;327(1):75-76. doi: 10.1001/jama.2021.20356. PMID: 34982132.
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Showing 25 to 36 of 48 entries